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Editorial
September 19, 2025
- Lifesaving power of preparedness in dialysis units
- Kyung Don Yoo
- Kidney Res Clin Pract. 2026;45(4):441-443.
- Editorials
- Lifesaving power of preparedness in dialysis units
- Kyung Don Yoo
- Kidney Res Clin Pract. 2026;45(4):441-443. Published online September 19, 2025
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- Interobserver reproducibility in histopathological findings of lupus nephritis: how can we improve it?
- Kyung Chul Moon
- Kidney Res Clin Pract. 2026;45(4):444-446. Published online September 26, 2025
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- Special Article
- Clinical practice recommendations for the management of Alport syndrome: a joint statement of the Korean Society of Nephrology and the Korean Society of Pediatric Nephrology
- Ji Hyun Kim, Young-Hwan Hwang, Eunjeong Kang, Hee Gyung Kang, Dong Ah Park, Ho Sik Shin, Min Hyun Cho, Yo Han Ahn
- Kidney Res Clin Pract. 2026;45(4):447-458. Published online June 17, 2026
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Background: Alport syndrome (AS) is a hereditary kidney disorder characterized by progressive hematuria, proteinuria, and kidney failure, frequently accompanied by hearing loss and ocular abnormalities. Although blockade of the renin-angiotensin system (RAS) is established as the first-line therapy, additional pharmacological interventions have been explored. To formulate evidence-based recommendations tailored to the Korean healthcare setting, the Genetic Kidney Disease Study Group...
- Review Articles
- The importance and clinical utility of reanalysis of exome and genome sequencing data
- Dongseok Moon, Go Hun Seo
- Kidney Res Clin Pract. 2026;45(4):459-466. Published online November 26, 2025
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Exome sequencing (ES) and genome sequencing (GS) are essential for diagnosing rare genetic disorders, yet a significant number of patients remain without a definitive diagnosis after the initial analysis. Reanalysis of existing ES and GS data has emerged as a clinically indispensable practice, offering the potential to solve previously unresolved cases by leveraging rapid advances in genomic knowledge and technology....
- Cardiovascular disease and risk management in patients with nephrotic syndrome
- Clemens Untersulzner, Philipp Gauckler, Anna Matyjek, Sayna Norouzi, Renate Pichler, Andreas Kronbichler
- Kidney Res Clin Pract. 2026;45(4):467-478. Published online December 10, 2025
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Nephrotic syndrome, defined by proteinuria ≥3.5 g/24 hr, hypoalbuminemia, hyperlipidemia, and edema, shows a significantly elevated risk of both arterial and venous thromboembolic complications. Large cohort studies have demonstrated an up to two-fold increase in myocardial infarction and stroke incidence and an eight-fold increase in venous thromboembolism, especially among patients with membranous nephropathy. The increased cardiovascular vulnerability in this population...
- Transcriptional regulatory factors of the Aqp2 gene
- Hyun Jun Jung, Euijung Park, Hyo-Ju Jang, Tae-Hwan Kwon
- Kidney Res Clin Pract. 2026;45(4):479-494. Published online September 30, 2025
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Aquaporin-2 (AQP2), the water channel protein exclusively expressed in the kidney collecting duct, plays an essential role in water reabsorption and fluid homeostasis. Dysregulation of Aqp2 transcription and changes in protein abundance lead to water balance disorders such as nephrogenic diabetes insipidus or water overload states. Recent studies have revealed that Aqp2 transcription is highly selective, with only 35 of...
- Original Articles
- Effect of preparedness of emergency equipment on patient survival in hemodialysis facilities: a Korean nationwide cohort study
- Se Yeon Park, Yo Seop Cha, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee
- Kidney Res Clin Pract. 2026;45(4):495-503. Published online March 27, 2025
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Background: Intradialytic cardiac arrest is a serious complication of hemodialysis (HD) in patients with end-stage kidney disease. Therefore, appropriate emergency equipment should be prepared before the initiation of HD. However, little is known about the effects of preparedness of emergency equipment on the outcomes of patients undergoing HD. We aimed to evaluate the effects of preparedness of emergency equipment on...
- Interobserver agreement analysis among renal pathologists in classification of lupus nephritis using a digital pathology image dataset: after a third evaluation
- Ju Yeon Pyo, Nara Jeon, Su-Jin Shin, Minsun Jung, Beom Jin Lim, Minseob Eom, Sung-Eun Choi
- Kidney Res Clin Pract. 2026;45(4):504-515. Published online December 11, 2024
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Background: Lupus nephritis is well-known for low concordance in classification. Furthermore, there has been no agreement analysis among Korean renal pathologists regarding lupus nephritis. Inconsistent diagnosis leads to confusion and increases medical costs, as well as failure of appropriate therapeutic interventions. This study aimed to assess the level of agreement among Korean renal pathologists regarding classification. Methods: Representative glomerular images...
- Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study
- Yaerim Kim, Kyungho Ha, Jeonghwan Lee, Eunjin Bae, Jin Hyuk Paek, Woo Yeong Park, Kyubok Jin, Seungyeup Han, Dong Ki Kim, Chun Soo Lim, Jung Pyo Lee
- Kidney Res Clin Pract. 2026;45(4):516-529. Published online November 12, 2024
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Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status. Methods: We used data from the U.S. National Health and Nutrition Examination Survey 1999–2016. The intake of FAs was estimated as a percentage of...
- Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD)
- Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Tae-Hyun Yoo, Soo Wan Kim
- Kidney Res Clin Pract. 2026;45(4):530-540. Published online November 18, 2024
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Background: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression. Methods: A total of 1,130 patients with CKD stage...
- Methylcrotonyl-CoA carboxylase 2 supports leucine catabolism to promote mitochondrial biogenesis and alleviate cisplatin-induced acute kidney injury
- Hu Li, Kangqiang Weng, Hao Qi, Huiyue Qi, Linlu She, Junliang Qiu, Yingbo Dai
- Kidney Res Clin Pract. 2026;45(4):541-564. Published online January 9, 2025
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Background: Cisplatin is widely used in clinical practice, but its nephrotoxicity severely limits its use. Previous studies have shown that cisplatin-induced acute kidney injury (AKI) is closely related to mitochondrial damage and that alleviating mitochondrial dysfunction can alleviate cisplatin-induced AKI. Methylcrotonyl‑CoA carboxylase 2 (MCCC2) is mainly located in mitochondria, where it catalyzes the catabolism of leucine and maintains mitochondrial function;...
- Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study
- Minyoul Baik, Jimin Jeon, Joonsang Yoo, Hyo Suk Nam, Ji Hoe Heo, Jinkwon Kim, Young Dae Kim
- Kidney Res Clin Pract. 2026;45(4):565-575. Published online November 12, 2024
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Background: Patients with chronic kidney disease (CKD) are at high risk for cardiovascular disease (CVD). We aimed to evaluate whether hemodialysis (HD) initiation is associated with CVD risk in patients with CKD. Methods: This self-controlled case series, using data from a nationwide Korean health claims database, included patients with CKD who initiated HD between 2007 and 2019 and experienced CVD,...
- Blood osteoprotegerin is associated with arteriovenous access thrombosis in hemodialysis patients
- Tung-Ling Chung, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Yi-Chun Tsai, Ya-Ling Hsu, Mei-Chuan Kuo, Yi-Wen Chiu, Ping-Hsun Wu, Szu-Chia Chen
- Kidney Res Clin Pract. 2026;45(4):576-586. Published online October 25, 2024
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Background: A functioning arteriovenous (AV) access is essential for hemodialysis efficiency and the quality of life in hemodialysis patients. Blood osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa B ligand (RANKL) have been linked to cardiovascular diseases and vascular calcification. This study investigated the relationship between blood OPG, RANKL, and the occurrence of AV access thrombosis. Methods: This...
- Artificial intelligence-powered chest computed tomography analysis unveils prognostic insights for COVID-19 mortality among prevalent hemodialysis patients
- Eunji Kim, Soo-Jin Yoon, Sungbong Yu, Eunsil Ko, Kyungjun Shon, Jooyeon Yoon, Youn Kyung Kee, Do Hyoung Kim, AJin Cho, Hayne Cho Park, Young-Ki Lee
- Kidney Res Clin Pract. 2026;45(4):587-597. Published online September 26, 2024
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Background: Coronavirus disease 2019 (COVID-19) has led to severe pneumonia and mortality worldwide, however, clinical outcomes in end-stage renal disease patients remain unclear. This study evaluates the prognostic value of chest computed tomography (CT) findings in predicting COVID-19-related outcomes in prevalent hemodialysis patients. Methods: We retrospectively analyzed 326 prevalent hemodialysis patients diagnosed with COVID-19 who underwent chest CT scans. Characteristics...
- Effect of the geometry and severity of left ventricular hypertrophy on cardiovascular mortality in dialysis patients
- Yi-Chen Huang, Chung-Kuan Wu
- Kidney Res Clin Pract. 2026;45(4):598-611. Published online September 11, 2024
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Background: Left ventricular hypertrophy (LVH) is a vital risk factor for mortality of dialysis patients. The association of the geometry and severity of LVH with cardiovascular and all-cause mortality in hemodialysis (HD) patients remains unknown. This study investigated clinical outcomes among HD patients with different LVH geometric patterns and severity. Methods: The monocentric retrospective cohort study enrolled chronic HD patients...
- Comparison of clinical outcomes based on dialysis modality and icodextrin usage in patients on peritoneal dialysis
- Seok Hui Kang, Jun Young Do
- Kidney Res Clin Pract. 2026;45(4):612-622. Published online November 5, 2024
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Background: There is no conclusive evidence regarding the survival benefits of automated peritoneal dialysis (APD) or the use of icodextrin. This study aimed to evaluate patient and technique survival among four groups divided based on peritoneal dialysis modality and icodextrin use over 1 year. Methods: We specifically included patients who underwent a single peritoneal dialysis modality for at least 1...
- Genetic diagnosis of hereditary kidney disease in pediatric patients through whole-exome sequencing and mitochondrial DNA analysis
- Jiyoung Oh, Keumwha Lee, Dongju Won, Young-Mock Lee, Jae Il Shin
- Kidney Res Clin Pract. 2026;45(4):623-633. Published online May 15, 2026
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Background: Identifying the genetic cause of hereditary kidney disease is essential for appropriate management. However, pediatric patients often present with nonspecific renal symptoms such as proteinuria, hematuria, or both, making accurate diagnosis difficult. Mitochondrial diseases are also an important but underrecognized etiology of hereditary kidney disorders. This study aimed to assess the diagnostic utility of whole-exome sequencing (WES) combined with...
- Baseline characteristics and associated factors for hypertension in children with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Pediatric Chronic Kidney Disease study
- Ji Yeon Song, Keum Hwa Lee, Jae Il Shin, Hee Gyung Kang, Yo Han Ahn, Hee Sun Baek, Min Hyun Cho, Jiwon Jung, Joo Hoon Lee, Heeyeon Cho, Kyoung Hee Han, Eujin Park, Eun Mi Yang, Seong Heon Kim
- Kidney Res Clin Pract. 2026;45(4):634-643. Published online October 17, 2024
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Background: Hypertension is one of the most important complications of chronic kidney disease (CKD) as it exacerbates disease progression in children. The aim of this study is to identify characteristics and factors associated with hypertension in children with CKD. Methods: This is a cross-sectional study using baseline data from the 10-year ongoing cohort study named KNOW-PedCKD (Korean Cohort Study for...
- Corrigendum
- Corrigendum to “Triglyceride-glucose index and risk of renal function decline and death-censored renal allograft loss in kidney transplant recipients” [Kidney Res Clin Pract 2025;44(6):974–983]
- Hyo Jin Lee, Yu Ho Lee, Jin Sug Kim, Kyung Hwan Jeong, Jeong-Yeun Lee, Hye Eun Yoon, Ki-Ryang Na, Dong Ryeol Lee, Jaeseok Yang, Myoung Soo Kim, Amy M. Sitapati, Hyeon Seok Hwang
- Kidney Res Clin Pract. 2026;45(4):644-644. Published online June 25, 2026
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- Corrects: Kidney Res Clin Pract 2025;44(6):974
