Editorial

November 29, 2021


The role of the gut microbiota in acute kidney injury: a new therapeutic candidate?
Chan Ho Kim, Sung Jin Moon
Kidney Res Clin Pract. 2021;40(4):505-507.

Editorial

December 3, 2021


Pathologic findings of Fabry nephropathy: the pivotal role of kidney biopsy
Jung-ho Shin, Su Hyun Kim
Kidney Res Clin Pract. 2021;40(4):508-511.

Review Article

November 12, 2021


Hereditary kidney diseases associated with hypomagnesemia
Felix Claverie-Martin, Ana Perdomo-Ramirez, Victor Garcia-Nieto
Kidney Res Clin Pract. 2021;40(4):512-526.

Review Article

November 1, 2021


Fructose in the kidney: from physiology to pathology
Takahiko Nakagawa, Duk-Hee Kang
Kidney Res Clin Pract. 2021;40(4):527-541.

Review Article

November 17, 2021


The roles of sodium and volume overload on hypertension in chronic kidney disease
Jinho Shin, Chang Hwa Lee
Kidney Res Clin Pract. 2021;40(4):542-554.

Review Article

November 22, 2021


Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease
In-Jeong Cho, Seok-Min Kang
Kidney Res Clin Pract. 2021;40(4):555-565.

Review Article

November 1, 2021


When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury
Jung Nam An, Sung Gyun Kim, Young Rim Song
Kidney Res Clin Pract. 2021;40(4):566-577.

Special Article

December 10, 2021


Executive Summary of the Korean Society of Nephrology 2021 Clinical Practice Guideline for Optimal Hemodialysis Treatment
Ji Yong Jung, Kyung Don Yoo, Eunjeong Kang, et al.
Kidney Res Clin Pract. 2021;40(4):578-595.

Original Article

September 10, 2021


Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury
Lilin Li, Jung Nam An, Jeonghwan Lee, et al.
Kidney Res Clin Pract. 2021;40(4):596-610.

Original Article

November 29, 2021


Fabry nephropathy before and after enzyme replacement therapy: important role of renal biopsy in patients with Fabry disease
Il Young Kim, Hyun Jung Lee, Chong Kun Cheon
Kidney Res Clin Pract. 2021;40(4):611-619.

Original Article

November 25, 2021


Probiotics partially attenuate the severity of acute kidney injury through an immunomodulatory effect
Jihyun Yang, Geun Eog Ji, Myeong Soo Park, et al.
Kidney Res Clin Pract. 2021;40(4):620-633.

Original Article

September 15, 2021


Renal outcomes of laparoscopic versus open surgery in patients with rectal cancer: a propensity score analysis
Jin Hyuk Paek, Sung Il Kang, Jiwon Ryu, et al.
Kidney Res Clin Pract. 2021;40(4):634-644.

Original Article

October 12, 2021


Metabolic risks in living kidney donors in South Korea
Eunjeong Kang, Jina Park, Hyo Jeong Kim, et al.
Kidney Res Clin Pract. 2021;40(4):645-659.

Original Article

November 29, 2021


Metformin use and cardiovascular outcomes in patients with diabetes and chronic kidney disease: a nationwide cohort study
Min-Ho Kim, Hyung Jung Oh, Soon Hyo Kwon, et al.
Kidney Res Clin Pract. 2021;40(4):660-672.

Original Article

August 17, 2021


Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
Sukdong Yoo, Min Hyun Cho, Hee Sun Baek, et al.
Kidney Res Clin Pract. 2021;40(4):673-686.

Original Article

August 11, 2021


Clinical outcomes and prognostic factors of mortality in liver cirrhosis patients on continuous renal replacement therapy in two tertiary hospitals in Korea
You Hyun Jeon, Il Young Kim, Gum Sook Jang, et al.
Kidney Res Clin Pract. 2021;40(4):687-697.

Original Article

October 20, 2021


Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease
Kyoung Woon Kim, Yoo Jin Shin, Bo-Mi Kim, et al.
Kidney Res Clin Pract. 2021;40(4):698-711.

Original Article

August 6, 2021


Neutrophil extracellular traps and heparin-induced antibodies contribute to vascular access thrombosis in hemodialysis patients
Hoi Woul Lee, Jung Nam An, Hyung Seok Lee, et al.
Kidney Res Clin Pract. 2021;40(4):712-723.

Original Article

August 31, 2021


Effects of the route of erythropoietin administration on hemoglobin variability and cardiovascular events in hemodialysis patients
Do Hyoung Kim, Young-Ki Lee, Juhee Kim, et al.
Kidney Res Clin Pract. 2021;40(4):724-733.

Editorial
The role of the gut microbiota in acute kidney injury: a new therapeutic candidate?
Chan Ho Kim, Sung Jin Moon
Kidney Res Clin Pract. 2021;40(4):505-507.   Published online November 29, 2021
Pathologic findings of Fabry nephropathy: the pivotal role of kidney biopsy
Jung-ho Shin, Su Hyun Kim
Kidney Res Clin Pract. 2021;40(4):508-511.   Published online December 3, 2021
Review Article
Hereditary kidney diseases associated with hypomagnesemia
Felix Claverie-Martin, Ana Perdomo-Ramirez, Victor Garcia-Nieto
Kidney Res Clin Pract. 2021;40(4):512-526.   Published online November 12, 2021
In the kidney, a set of proteins expressed in the epithelial cells of the thick ascending loop of Henle and the distal convoluted tubule directly or indirectly play important roles in the regulation of serum magnesium levels. Magnesium reabsorption in the thick ascending loop of Henle occurs through a passive paracellular pathway, while in the distal convoluted tubule, the final...
Fructose in the kidney: from physiology to pathology
Takahiko Nakagawa, Duk-Hee Kang
Kidney Res Clin Pract. 2021;40(4):527-541.   Published online November 1, 2021
The Warburg effect is a unique property of cancer cells, in which glycolysis is activated instead of mitochondrial respiration despite oxygen availability. However, recent studies found that the Warburg effect also mediates non-cancer disorders, including kidney disease. Currently, diabetes or glucose has been postulated to mediate the Warburg effect in the kidney, but it is of importance that the Warburg...
The roles of sodium and volume overload on hypertension in chronic kidney disease
Jinho Shin, Chang Hwa Lee
Kidney Res Clin Pract. 2021;40(4):542-554.   Published online November 17, 2021
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular (CV) events, and the disease burden is rising rapidly. An important contributor to CV events and CKD progression is high blood pressure (BP). The main mechanisms of hypertension in early and advanced CKD are renin-angiotensin system activation and volume overload, respectively. Sodium retention is well known as a factor...
Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease
In-Jeong Cho, Seok-Min Kang
Kidney Res Clin Pract. 2021;40(4):555-565.   Published online November 22, 2021
Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades. The neprilysin inhibitor enhances the activity of natriuretic peptides, producing vasodilation, natriuresis, and diuresis. Angiotensin receptor blockers inhibit the renin-angiotensin-aldosterone system. Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI), has been...
When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury
Jung Nam An, Sung Gyun Kim, Young Rim Song
Kidney Res Clin Pract. 2021;40(4):566-577.   Published online November 1, 2021
Acute kidney injury (AKI) is a common condition in critically ill patients, and may contribute to significant medical, social, and economic consequences, including death. Although there have been advances in medical technology, including continuous renal replacement therapy (CRRT), the mortality rate of AKI is high, and there is no fundamental treatment that can reverse disease progression. The decision to implement...
Special Article
Executive Summary of the Korean Society of Nephrology 2021 Clinical Practice Guideline for Optimal Hemodialysis Treatment
Ji Yong Jung, Kyung Don Yoo, Eunjeong Kang, Hee Gyung Kang, Su Hyun Kim, Hyoungnae Kim, Hyo Jin Kim, Tae-Jin Park, Sang Heon Suh, Jong Cheol Jeong, Ji-Young Choi, Young-Hwan Hwang, Miyoung Choi, Yae Lim Kim, Kook-Hwan Oh
Kidney Res Clin Pract. 2021;40(4):578-595.   Published online December 10, 2021
The Korean Society of Nephrology (KSN) has published a clinical practice guideline (CPG) document for maintenance hemodialysis (HD). The document, 2021 Clinical Practice Guideline on Optimal HD Treatment, is based on an extensive evidence-oriented review of the benefits of preparation, initiation, and maintenance therapy for HD, with the participation of representative experts from the KSN under the methodologists’ support for...
The full-text version of this CPG is available on the KRCP website (https://doi.org/10.23876/j.krcp.21.600).
Original Article
Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury
Lilin Li, Jung Nam An, Jeonghwan Lee, Dong Jin Shin, Shi Mao Zhu, Jin Hyuk Kim, Dong Ki Kim, Dong-Ryeol Ryu, Sejoong Kim, Jung Pyo Lee
Kidney Res Clin Pract. 2021;40(4):596-610.   Published online September 10, 2021
Background: Hepatocyte growth factor (HGF)/cMet pathway is necessary for repair and regeneration following acute kidney injury (AKI). We evaluated the clinical potential of plasma HGF and soluble cMet as prognostic biomarkers for severe AKI requiring continuous renal replacement therapy (CRRT). Methods: One hundred thirty-six patients with severe AKI who participated in the VENUS (volume management under body composition monitoring in critically...
Fabry nephropathy before and after enzyme replacement therapy: important role of renal biopsy in patients with Fabry disease
Il Young Kim, Hyun Jung Lee, Chong Kun Cheon
Kidney Res Clin Pract. 2021;40(4):611-619.   Published online November 29, 2021
Background: In Fabry disease, the presence of globotriaosylceramide (GL3) deposits in various kidney cells leads to progressive renal dysfunction. However, kidney biopsy studies in patients with Fabry disease are limited. In the present study, the pathologic findings of patients with Fabry nephropathy receiving enzyme replacement therapy (ERT) and untreated patients without albuminuria were investigated. Methods: The present study included 15 patients...
Probiotics partially attenuate the severity of acute kidney injury through an immunomodulatory effect
Jihyun Yang, Geun Eog Ji, Myeong Soo Park, Yeong-Je Seong, Yoon Sook Go, Hee Young Lee, Yina Fang, Myung-Gyu Kim, Se Won Oh, Won Yong Cho, Sang-Kyung Jo
Kidney Res Clin Pract. 2021;40(4):620-633.   Published online November 25, 2021
Background: A healthy microbiome helps maintain the gut barrier and mucosal immune tolerance. Previously, we demonstrated that acute kidney injury (AKI) provoked dysbiosis, gut inflammation, and increased permeability. Here, we investigated the renoprotective effects of the probiotic Bifidobacterium bifidum BGN4 and the underlying mechanisms thereof. Methods: C57BL/6 mice were subjected to bilateral renal ischemia-reperfusion injury (IRI) or sham operation....
Renal outcomes of laparoscopic versus open surgery in patients with rectal cancer: a propensity score analysis
Jin Hyuk Paek, Sung Il Kang, Jiwon Ryu, Sung Yoon Lim, Ji Young Ryu, Hyung Eun Son, Jong Cheol Jeong, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Sung-Bum Kang, Sejoong Kim
Kidney Res Clin Pract. 2021;40(4):634-644.   Published online September 15, 2021
Background: A laparoscopic approach is widely used in abdominal surgery. Although several studies have compared surgical and oncological outcomes between laparoscopic surgery (LS) and open surgery (OS) in rectal cancer patients, there have been few studies on postoperative renal outcomes. Methods: We conducted a retrospective cohort study involving 1,633 patients who underwent rectal cancer surgery between 2003 and 2017....
Metabolic risks in living kidney donors in South Korea
Eunjeong Kang, Jina Park, Hyo Jeong Kim, Sehoon Park, Minsu Park, Yaerim Kim, Kwangsoo Kim, Sang Min Park, Dong-Wan Chae, Ho Jun Chin, Jung Pyo Lee, Sik Lee, Soo Wan Kim, Jang-Hee Cho, Miyeun Han, Yong Chul Kim, Yon Su Kim, Insun Choi, Hajeong Lee
Kidney Res Clin Pract. 2021;40(4):645-659.   Published online October 12, 2021
Background: Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney donors compared to a control group. Methods: This study enrolled living kidney donors from seven hospitals from 1982 to 2016. The controls were individuals that voluntarily received health check-ups from...
Metformin use and cardiovascular outcomes in patients with diabetes and chronic kidney disease: a nationwide cohort study
Min-Ho Kim, Hyung Jung Oh, Soon Hyo Kwon, Jin Seok Jeon, Hyunjin Noh, Dong Cheol Han, Hyoungnae Kim, Dong-Ryeol Ryu
Kidney Res Clin Pract. 2021;40(4):660-672.   Published online November 29, 2021
Background: Metformin has recently been shown not to increase the risk of lactic acidosis in patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this population has expanded. However, the relationship between metformin use and clinical outcomes in CKD remains controversial. Methods: This study considered data from 97,713 diabetes patients with an estimated glomerular filtration rate of...
Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea
Sukdong Yoo, Min Hyun Cho, Hee Sun Baek, Ji Yeon Song, Hye Sun Lee, Eun Mi Yang, Kee Hwan Yoo, Su Jin Kim, Jae Il Shin, Keum Hwa Lee, Tae-Sun Ha, Kyung Mi Jang, Jung Won Lee, Kee Hyuck Kim, Heeyeon Cho, Mee Jeong Lee, Jin-Soon Suh, Kyoung Hee Han, Hye Sun Hyun, Il-Soo Ha, Hae Il Cheong, Hee Gyung Kang, Mee Kyung Namgoong, Hye-Kyung Cho, Jae-Hyuk Oh, Sang Taek Lee, Kyo Sun Kim, Joo Hoon Lee, Young Seo Park, Seong Heon Kim
Kidney Res Clin Pract. 2021;40(4):673-686.   Published online August 17, 2021
Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis and reveal the risk factors for acute kidney injury (AKI) in such cases. Methods: This retrospective study analyzed the medical records of children and adolescents diagnosed with rhabdomyolysis at 23 hospitals...
Clinical outcomes and prognostic factors of mortality in liver cirrhosis patients on continuous renal replacement therapy in two tertiary hospitals in Korea
You Hyun Jeon, Il Young Kim, Gum Sook Jang, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Hyo Jin Kim
Kidney Res Clin Pract. 2021;40(4):687-697.   Published online August 11, 2021
Background: Data on liver cirrhosis (LC) patients undergoing continuous renal replacement therapy (CRRT) are lacking despite the dismal prognosis. We therefore evaluated clinical characteristics and predictive factors related to mortality in LC patients undergoing CRRT. Methods: We performed a retrospective observational study at two tertiary hospitals in Korea. A total of 229 LC patients who underwent CRRT were analyzed. Patients were...
Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease
Kyoung Woon Kim, Yoo Jin Shin, Bo-Mi Kim, Sheng Cui, Eun Jeong Ko, Sun Woo Lim, Chul Woo Yang, Byung Ha Chung
Kidney Res Clin Pract. 2021;40(4):698-711.   Published online October 20, 2021
Background: Endothelial cell (EC) dysfunction is a frequent feature in patients with end-stage renal disease (ESRD). The aim of this study was to generate human induced pluripotent stem cells, differentiate ECs (hiPSC-ECs) from patients with ESRD, and appraise the usefulness of hiPSC-ECs as a model to investigate EC dysfunction. Methods: We generated hiPSCs using peripheral blood mononuclear cells (PBMCs) isolated...
Neutrophil extracellular traps and heparin-induced antibodies contribute to vascular access thrombosis in hemodialysis patients
Hoi Woul Lee, Jung Nam An, Hyung Seok Lee, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim, Jwa-Kyung Kim
Kidney Res Clin Pract. 2021;40(4):712-723.   Published online August 6, 2021
Background: Anti-heparin/platelet factor 4 (PF4) antibodies may trigger severe thrombotic complications in hemodialysis (HD) patients. Tetrameric PF4 has a high affinity for extracellular DNA, which is a key component of neutrophil extracellular traps (NETs); therefore, the interactions between anti-heparin/PF4 antibodies and NETs can contribute to prothrombotic events. This prospective observational study included both incident and maintenance HD (MHD) patients. Methods:...
Effects of the route of erythropoietin administration on hemoglobin variability and cardiovascular events in hemodialysis patients
Do Hyoung Kim, Young-Ki Lee, Juhee Kim, Hayne Cho Park, Kyu Sang Yun, AJin Cho, Jong-Woo Yoon, Ja-Ryong Koo, Jung-Woo Noh
Kidney Res Clin Pract. 2021;40(4):724-733.   Published online August 31, 2021
Introduction: Despite the routine use of erythropoietin in hemodialysis patients to correct anemia, its administration route’s effects on hemoglobin variability and cardiovascular events remain elusive. Herein, we determined different erythropoietin administration routes’ effects on hemoglobin variability in hemodialysis patients and the associated factors of hemoglobin variability and cardiovascular events. Methods: This is a post hoc analysis of a prospective, controlled, randomized,...

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Online ISSN: 2211-9140


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