Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients?
Yohei Komaru, Kent Doi
Kidney Res Clin Pract. 2021;40(2):177-179.   Published online June 9, 2021
Review Article
Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Sagar Verma, Priyanka Singh, Shiffali Khurana, Nirmal Kumar Ganguly, Ritushree Kukreti, Luciano Saso, Devinder Singh Rana, Vibha Taneja, Vinant Bhargava
Kidney Res Clin Pract. 2021;40(2):183-193.   Published online May 26, 2021
Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activities, but high levels lead to toxicity and are associated with various diseases. Levels of ROS are maintained as a balance between oxidants and antioxidants. Accumulating data suggest that oxidative stress is a major factor in deterioration of renal function. In this review, we highlight the possible...
Extracellular vesicles in kidneys and their clinical potential in renal diseases
Sul A Lee, Chulhee Choi, Tae-Hyun Yoo
Kidney Res Clin Pract. 2021;40(2):194-207.   Published online April 13, 2021
Extracellular vesicles (EVs), such as exosomes and microvesicles, are cell-derived lipid bilayer membrane particles, which deliver information from host cells to recipient cells. EVs are involved in various biological processes including the modulation of the immune response, cell-to-cell communications, thrombosis, and tissue regeneration. Different types of kidney cells are known to release EVs under physiologic as well as pathologic conditions,...
Original Article
Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis
Sungjin Chung, Mina Son, Yura Chae, Songhee Oh, Eun Sil Koh, Yong Kyun Kim, Seok Joon Shin, Cheol Whee Park, Sung-Chul Jung, Ho-Shik Kim
Kidney Res Clin Pract. 2021;40(2):208-219.   Published online May 21, 2021
Background: Fabry disease is a rare X-linked genetic lysosomal disorder caused by mutations in the GLA gene encoding alpha-galactosidase A. Despite some data showing that profibrotic and proinflammatory cytokines and oxidative stress could be involved in Fabry disease-related renal injury, the pathogenic link between metabolic derangement within cells and renal injury remains unclear. Methods: Renal fibrosis was triggered by unilateral ureteral...
Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome
Kipyo Kim, Eunji Baek, Suryeong Go, Hyung-Eun Son, Ji-Young Ryu, Yongjin Yi, Jong Cheol Jeong, Sejoong Kim, Ho Jun Chin
Kidney Res Clin Pract. 2021;40(2):220-230.   Published online June 9, 2021
Backgrounds: Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes. However, the impact of GFR estimation methods on the accuracy and effectiveness of surrogate markers is unknown. Methods: We retrospectively enrolled participants in health screening programs at three...
Twenty-four-hour serum creatinine variation is associated with poor outcome in the novel coronavirus disease 2019 (COVID-19) patients
Gaetano Alfano, Annachiara Ferrari, Francesco Fontana, Giacomo Mori, Giulia Ligabue, Silvia Giovanella, Riccardo Magistroni, Marianna Meschiari, Erica Franceschini, Marianna Menozzi, Gianluca Cuomo, Gabriella Orlando, Antonella Santoro, Margherita Di Gaetano, Cinzia Puzzolante, Federica Carli, Andrea Bedini, Jovana Milic, Cristina Mussini, Gianni Cappelli, Giovanni Guaraldi
Kidney Res Clin Pract. 2021;40(2):231-240.   Published online April 26, 2021
Background: Serum creatinine (sCr) elevation has been associated with all-cause in-hospital mortality. The prognostic value of within-day sCr variation is unknown in the setting of the novel coronavirus disease 2019 (COVID-19). Our study aimed to evaluate the prognostic significance of 24-hour sCr variation in COVID-19 patients. Methods: A monocentric retrospective analysis was conducted in a cohort of COVID-19 patients not admitted...
Acute kidney injury and mortality in coronavirus disease 2019: results from a cohort study of 1,280 patients
Natalia Chebotareva, Svetlana Berns, Angelina Berns, Tatyana Androsova, Marina Lebedeva, Sergey Moiseev
Kidney Res Clin Pract. 2021;40(2):241-249.   Published online June 2, 2021
Background: The development of acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is associated with a high risk of death. Published data demonstrate the possibility of severe kidney injury in patients suffering from COVID-19. However, these data are still controversial. Methods: A total of 1,280 patients with a proven diagnosis of COVID-19 were included in our study. COVID-19...
Changes in metabolic parameters and adverse kidney and cardiovascular events during glomerulonephritis and renal vasculitis treatment in patients with and without diabetes mellitus
Cynthia C. Lim, Jason C. J. Choo, Hui Zhuan Tan, Irene Y. J. Mok, Yok Mooi Chin, Choong Meng Chan, Keng Thye Woo
Kidney Res Clin Pract. 2021;40(2):250-262.   Published online May 21, 2021
Background: Cardiovascular disease is a major contributor to morbidity and mortality in patients with glomerulonephritis, which is increasingly diagnosed in older individuals who may have diabetes mellitus (DM). We evaluated the impact of DM on metabolic profiles as well as renal and cardiovascular outcomes during treatment and follow-up of individuals with glomerulonephritis. Methods: We performed a retrospective cohort study of 601...
Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients
Chatchai Kreepala, Pitirat Panpruang, Rapeeporn Yodprom, Teeraya Piyajarawong, Krittanont Wattanavaekin, Taechasit Danjittrong, Sadiporn Phuthomdee
Kidney Res Clin Pract. 2021;40(2):263-271.   Published online June 2, 2021
Background: Literature regarding FRMD3 polymorphisms has suggested that they could be an alternative test to differentiate diabetic nephropathy (DN) from nondiabetic renal disease (NDRD) in type 2 diabetes mellitus (DM) patients. This study was performed to investigate the relationship between the FRMD3 gene and clinical characteristics of DN. Methods: Patients who already had renal pathologic results were tested for FRMD3 polymorphisms....
Effects of residential greenness on clinical outcomes of patients with chronic kidney disease: a large-scale observation study
Jae Yoon Park, Jiyun Jung, Yong Chul Kim, Hyewon Lee, Ejin Kim, Yon Su Kim, Ho Kim, Jung Pyo Lee
Kidney Res Clin Pract. 2021;40(2):272-281.   Published online May 26, 2021
Background: As industrialization and urbanization are accelerating, the distribution of green areas is decreasing, particularly in developing countries. Since the 2000s, the effects of surrounding greenness on self-perceived health, including physical and mental health, longevity, and obesity have been reported. However, the effects of surrounding green space on chronic kidney disease are not well understood. Therefore, we investigated the impact...
Causal effect of alcohol use on the risk of end-stage kidney disease and related comorbidities: a Mendelian randomization study
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Kidney Res Clin Pract. ;40(2):282-293.   Published online April 20, 2021
Background: An inverse observational association between alcohol use and the risk of chronic kidney disease (CKD) or end-stage kidney disease (ESKD) has been reported. The causal effect of alcohol use on the risk of ESKD warrants additional investigation. Methods: The study was an observational cohort study investigating the UK Biobank and performed Mendelian randomization (MR) analysis. Amounts of alcohol use...
Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients
Maryanne Zilli Canedo Silva, Karina Jesus Antonio, João Marcos Soares Reis, Leticia Salmazzo Alves, Jacqueline Costa Teixeira Caramori, Barbara Perez Vogt
Kidney Res Clin Pract. 2021;40(2):294-303.   Published online May 27, 2021
Background: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. Methods: Patients with chronic...
Impact of high body mass index on allograft outcomes in kidney transplant recipients with presensitization to human leukocyte antigen
Yohan Park, Hanbi Lee, Eun Jeong Ko, Sua Lee, Tae Hyun Ban, Ji-Won Min, Hye-Eun Yoon, Eun-Jee Oh, Chul Woo Yang, Byung Ha Chung
Kidney Res Clin Pract. 2021;40(2):304-316.   Published online April 30, 2021
Background: This study aimed to investigate whether high body mass index (BMI) and presensitization to human leukocyte antigen (HLA) in kidney transplant recipients (KTRs) affected allograft outcomes. Methods: From January 2010 to December 2018, 1,290 kidney transplantations (KTs) were performed at the Seoul St Mary’s Hospital. Of these, 682 cases of ABO-compatible living donor KT patients were enrolled. They were divided...
Clinical significance of serum galactose-deficient immunoglobulin A1 for detection of recurrent immunoglobulin A nephropathy in kidney transplant recipients
Woo Yeong Park, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han
Kidney Res Clin Pract. 2021;40(2):317-324.   Published online April 15, 2021
Background: Recurrent glomerulonephritis (GN) is a common cause of allograft loss in kidney transplantation (KT), the most frequent of which is immunoglobulin A (IgA) nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) plays a major role in the pathophysiology of IgAN, but the association between Gd-IgA1 and recurrent IgAN in kidney transplant recipients (KTRs) is uncertain. We aimed to evaluate the efficacy of...
The removal capacity of asymmetric cellulose triacetate during post-dilution online hemodiafiltration
Alba Santos, Nicolás Macías, Leonidas Cruzado, Almudena Vega
Kidney Res Clin Pract. 2021;40(2):325-327.   Published online April 14, 2021

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