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Editorial
September 9, 2025
- One complication, two conditions: Rethinking intradialytic hypotension in acute kidney injury and end-stage kidney disease
- Seok Hui Kang
- Kidney Res Clin Pract. 2026;45(1):1-3.
- Editorials
- One complication, two conditions: Rethinking intradialytic hypotension in acute kidney injury and end-stage kidney disease
- Seok Hui Kang
- Kidney Res Clin Pract. 2026;45(1):1-3. Published online September 9, 2025
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- Toward precision nephrology: identification of cause-specific chronic kidney disease biomarkers through multiomics integration in Korean cohorts
- Jong Hyun Jhee
- Kidney Res Clin Pract. 2026;45(1):4-6. Published online October 2, 2025
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- Review Articles
- The role of extracellular vesicles in kidney disease progression
- Ran Kim, Tae Min Kim
- Kidney Res Clin Pract. 2026;45(1):7-21. Published online December 20, 2024
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Extracellular vesicles (EVs) are nanosized membranous particles released by nearly all cell types, playing a crucial role in mediating cell-to-cell communication. The molecular profile of EVs often reflects that of their originating cells, rendering them valuable for therapeutic and diagnostic purposes. The kidney comprises various cell types, and urinary EVs are predominantly produced from tubular, glomerular, and urinary bladder cells....
- Renal fibrosis: research progress on mechanisms and therapeutic strategies
- Cheng-Xiao Yin, Jia-Rui Fan, Xiao-Gang Du
- Kidney Res Clin Pract. 2026;45(1):22-35. Published online February 21, 2025
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Renal fibrosis (RF) is a prevalent clinical symptom of numerous chronic kidney illnesses and a significant pathological alteration in end-stage renal disease resulting from various mechanisms, such as abnormally activated signaling pathways, microRNAs, aging, autophagy disorders, and fibrotic ecological niches, all of which contribute to RF development. Inhibiting, blocking, or delaying the aforementioned mechanisms may yield novel approaches for treating...
- Urinary extracellular vesicle proteins for biomarker discovery in chronic kidney disease
- Chul Won Seo, Eun-Young Lee, Jae Sang Oh, Dongsic Choi
- Kidney Res Clin Pract. 2026;45(1):36-49. Published online December 16, 2025
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Chronic kidney disease (CKD) is a progressive condition characterized by declining kidney function principally driven by diabetes mellitus, glomerulonephritis, and hypertension. Although renal biopsy is the gold standard for diagnosing CKD, its invasive nature restricts its use for early detection and routine clinical applications. Current noninvasive biomarkers, including the estimated glomerular filtration rate and albumin-to-creatinine ratio, are useful indicators of...
- Original Articles
- Integrated genomics and metabolomics to identify cause-specific biomarkers for chronic kidney disease in a Korean population
- Min Woo Kang, Ji-Eun Kim, Jihyun Kang, Seonmi Kim, JooYong Park, Sohyun Bae, Yon Su Kim, Ji-Yeob Choi, Joo-Youn Cho, Seung Seok Han
- Kidney Res Clin Pract. 2026;45(1):50-64. Published online June 2, 2025
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Background: The heterogeneity of chronic kidney disease (CKD) and fragmented analysis methods hinder the precise identification of novel biomarkers. We addressed this challenge using two independent cohorts to integrate genomics and metabolomics, aiming to identify cause-specific biomarkers for CKD in the Korean population. Methods: A longitudinal genome-wide association study using the Cox proportional hazards model was conducted using the Ansan and...
- Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study
- Jihyun Yang, Hui Seung Lee, Chi-Yeon Lim, Hyunsuk Kim, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong, Eunjin Bae, Young Youl Hyun
- Kidney Res Clin Pract. 2026;45(1):65-76. Published online February 22, 2024
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Background: Obesity is a well-known risk factor for chronic kidney disease and its progression. However, the impact of obesity on the renal function of the elderly population is uncertain. We investigated the association between obesity and renal outcomes in the elderly. Methods: We analyzed 130,504 participants from the Korean National Health Insurance Service-Senior cohort. Obesity was classified according to body...
- Intradialytic hypotension and worse outcomes in patients with acute kidney injury requiring intermittent hemodialysis
- Yeong-Won Park, Donghwan Yun, Yeojin Yu, Sang Hyun Kim, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seong Geun Kim, Seung Seok Han
- Kidney Res Clin Pract. 2026;45(1):77-85. Published online February 19, 2024
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Background: Intradialytic hypotension (IDH) is a critical complication related to worse outcomes in patients undergoing maintenance hemodialysis. Herein, we addressed the impact of IDH on mortality and other outcomes in patients with severe acute kidney injury (AKI) requiring intermittent hemodialysis. Methods: We retrospectively reviewed 1,009 patients who underwent intermittent hemodialysis due to severe AKI. IDH was defined as either dialysis discontinuation...
- Association of metformin with cardiovascular and graft outcomes in kidney transplant recipients with posttransplantation diabetes mellitus
- Dongyeon Lee, Jiyun Jung, Sichan Kim, Jaeyun Lee, Jangwook Lee, Chung Hee Baek, Hyunwook Kwon, Sung Shin, Younghoon Kim, Sung Joon Shin, Su-Kil Park, Jae Yoon Park, Hyosang Kim
- Kidney Res Clin Pract. 2026;45(1):86-98. Published online January 12, 2024
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Background: Posttransplantation diabetes mellitus (PTDM) is a crucial problem after kidney transplantation. We aimed to determine whether metformin affects cardiovascular and graft outcomes in patients with PTDM. Methods: This retrospective cohort study included 1,663 kidney transplant recipients without preexisting diabetes mellitus. The patients were divided into metformin and non-metformin groups, with matched propensity scores. We also estimated metformin’s effect on percutaneous...
- Clinical features and outcomes of immunoglobulin G4-related kidney disease and immunoglobulin G4-related retroperitoneal fibrosis in Korea
- Sua Lee, Chul Woo Yang
- Kidney Res Clin Pract. 2026;45(1):99-109. Published online April 11, 2025
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Background: Immunoglobulin G4 (IgG4)-related disease (RD) is a newly recognized disease, and a few epidemiologic studies about this disorder have been published. This research aimed to demonstrate the clinical features and outcomes of IgG4-related kidney disease (RKD) and IgG4-related retroperitoneal fibrosis (RPF) compared to other organs’ involvement. Methods: Patients who were diagnosed with IgG4-RD from January 2009 to July 2019 at...
- Associated factors of osteoporosis and the impact of osteoporosis on all-cause mortality in incident hemodialysis older patients
- Seunghye Lee, Yoomee Kang, Yu Ah Hong, Sung Joon Shin, Soon Hyo Kwon, Sungjin Chung, Young Youl Hyun, Sang Heon Song, Jae Won Yang, Won Min Hwang, Jang-Hee Cho, Kyung Don Yoo, In O Sun, Gang-Jee Ko, Byung Chul Yu, Hyunsuk Kim, Woo Yeong Park, Tae Won Lee, Dong Jun Park, Eunjin Bae
- Kidney Res Clin Pract. 2026;45(1):110-119. Published online September 18, 2025
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Background: With the aging population and advancements in medical care worldwide, the number of older patients with end-stage kidney disease continues to rise. This study aimed to identify factors associated with osteoporosis and osteopenia in older patients undergoing incident hemodialysis and assess their impact on mortality. Methods: We analyzed a large multicenter retrospective cohort of patients aged ≥70 years undergoing...
- Lead augmented vector right T wave and elevated E/e′ ratio identify hemodialysis patients at high cardiovascular risk
- Juyeon Park, Daseul Huh, In Mee Han, Youn Kyung Kee, Hee Jung Jeon, Jieun Oh, Dong Ho Shin
- Kidney Res Clin Pract. 2026;45(1):120-129. Published online November 26, 2025
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Background: This study was performed to evaluate the prognostic utility of a positive T wave in lead augmented vector right (TaVR) and elevated E/e′ ratio in predicting major adverse cardiovascular events (MACE) in patients receiving maintenance hemodialysis. Methods: We retrospectively examined 296 adults on thrice-weekly hemodialysis with baseline electrocardiography and transthoracic echocardiography (October 2018–April 2024). TaVR positivity was T-wave amplitude, >0...
- Study Protocol
- A Pragmatic Randomized clinical trial: twice-weekly vs. thrice-weekly Incident hemoDialysis in Elderly patients (PRIDE): study protocol
- Miyeun Han, Huiwon Jeon, Byung Chul Yu, Sang Heon Song, Sungjin Chung, Chiyeon Lim, Hojoon Sohn, Jin-Won Noh, Soon Hyo Kwon
- Kidney Res Clin Pract. 2026;45(1):130-139. Published online December 18, 2023
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Background: The optimal frequency for hemodialysis in older adults with end-stage kidney disease (ESKD) has not been established. This study aims to investigate whether a twice-weekly dialysis schedule using an incremental approach can reduce hospitalization rates in the elderly with incident dialysis, compared with conventional thrice-weekly dialysis. Methods: We have designed a pragmatic randomized controlled trial to compare the effects...
- Correspondence
- Blood groups distribution doesn’t explain Gitelman and Bartter syndromes COVID-19 resistance: implications for glycosylation-based protection
- Martina Cacciapuoti, Lucia Federica Stefanelli, Dorella Del Prete, Federico Nalesso, Paul A Davis, Lorenzo A Calò
- Kidney Res Clin Pract. 2026;45(1):140-142. Published online October 30, 2025
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