Review Article

November 12, 2020


New insights into the role of heme oxygenase-1 in acute kidney injury
Meryl Nath, Anupam Agarwal
Kidney Res Clin Pract. 2020;39(4):387-401.

Review Article

November 20, 2020


Genetic background, recent advances in molecular biology, and development of novel therapy in Alport syndrome
Kandai Nozu, Yutaka Takaoka, Hirofumi Kai, et al.
Kidney Res Clin Pract. 2020;39(4):402-413.

Original Article

December 15, 2020


Cumulative fluid balance and mortality in elderly patients with acute kidney injury requiring continuous renal-replacement therapy: a multicenter prospective cohort study
Jong Hyun Jhee, Jae Yoon Park, Jung Nam An, et al.
Kidney Res Clin Pract. 2020;39(4):414-425.

Original Article

December 15, 2020


Impact of health-related quality of life on survival after dialysis initiation: a prospective cohort study in Korea
Jeonghwan Lee, Yong Chul Kim, Soie Kwon, et al.
Kidney Res Clin Pract. 2020;39(4):426-440.

Original Article

September 1, 2020


Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis
Keiji Hirai, Susumu Ookawara, Junki Morino, et al.
Kidney Res Clin Pract. 2020;39(4):441-450.

Original Article

November 13, 2020


Customized versus conventional video counseling for peritoneal dialysis decision-making in patients with stage 5 chronic kidney disease under a PD-first policy: a randomized controlled study
Watanyu Parapiboon, Wannapat Pitsawong, Laddaporn Wongluechai, et al.
Kidney Res Clin Pract. 2020;39(4):451-459.

Original Article

November 13, 2020


Clinical outcomes of infection-related hospitalization in incident peritoneal dialysis patients
Youngdong Jeon, Hyung Duk Kim, Yu Ah Hong, et al.
Kidney Res Clin Pract. 2020;39(4):460-468.

Original Article

October 7, 2020


Long-term survival of children following acute peritoneal dialysis in a resource-limited setting
Michael Abel Alao, Olayinka Rasheed Ibrahim, Adanze Onyenonachi Asinobi, et al.
Kidney Res Clin Pract. 2020;39(4):469-478.

Original Article

November 20, 2020


The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients
Mohamed S. AbdElhalim, Ahmed S. Kenawy, Heba H. El Demellawy, et al.
Kidney Res Clin Pract. 2020;39(4):479-486.

Original Article

August 28, 2020


Pathological features and outcomes of incidental renal cell carcinoma in candidate solid organ donors
Francesca Ambrosi, Costantino Ricci, Deborah Malvi, et al.
Kidney Res Clin Pract. 2020;39(4):487-494.

Original Article

December 11, 2020


Remote monitoring using donor-derived, cell-free DNA after kidney transplantation during the coronavirus disease 2019 pandemic
Steven R. Potter, Randall Hinojosa, Cliff D. Miles, et al.
Kidney Res Clin Pract. 2020;39(4):495-500.

Editorial
Becoming a high impact journal
Gheun-Ho Kim
Kidney Res Clin Pract. 2020;39(4):379-380.   Published online December 15, 2020
Patient education and care for end-stage kidney disease: one size never fits all
Kook-Hwan Oh
Kidney Res Clin Pract. 2020;39(4):384-386.   Published online December 11, 2020
Review Article
New insights into the role of heme oxygenase-1 in acute kidney injury
Meryl Nath, Anupam Agarwal
Kidney Res Clin Pract. 2020;39(4):387-401.   Published online November 12, 2020

Acute kidney injury (AKI) is attended by injury-related biomarkers appearing in the urine and serum, decreased urine output, and impaired glomerular filtration rate. AKI causes increased morbidity and mortality and can progress to chronic kidney disease and end-stage kidney failure. AKI is without specific therapies and is managed by supported care. Heme oxygenase-1 (HO-1) is a cytoprotective, inducible enzyme that...

Genetic background, recent advances in molecular biology, and development of novel therapy in Alport syndrome
Kandai Nozu, Yutaka Takaoka, Hirofumi Kai, Minoru Takasato, Kensuke Yabuuchi, Tomohiko Yamamura, Tomoko Horinouchi, Nana Sakakibara, Takeshi Ninchoji, China Nagano, Kazumoto Iijima
Kidney Res Clin Pract. 2020;39(4):402-413.   Published online November 20, 2020

Alport syndrome (AS) is a progressive inherited kidney disease characterized by hearing loss and ocular abnormalities. There are three forms of AS depending on inheritance mode: X-linked Alport syndrome (XLAS), autosomal recessive AS (ARAS), and autosomal dominant AS (ADAS). XLAS is caused by pathogenic variants in COL4A5, which encodes type IV collagen α5 chain, while ADAS and ARAS are caused...

Original Article
Cumulative fluid balance and mortality in elderly patients with acute kidney injury requiring continuous renal-replacement therapy: a multicenter prospective cohort study
Jong Hyun Jhee, Jae Yoon Park, Jung Nam An, Dong Ki Kim, Kwon Wook Joo, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Pyo Lee, Jung Tak Park
Kidney Res Clin Pract. 2020;39(4):414-425.   Published online December 15, 2020
Background

The effect of fluid balance on outcomes in elderly patients with acute kidney injury (AKI) requiring continuous renal-replacement therapy (CRRT) is not explained well. We investigated outcomes according to cumulative fluid balance (CFB) in elderly patients with AKI undergoing CRRT.

Methods

A total of 607 patients aged 65 years or older who started CRRT due to AKI were enrolled and...

Impact of health-related quality of life on survival after dialysis initiation: a prospective cohort study in Korea
Jeonghwan Lee, Yong Chul Kim, Soie Kwon, Lilin Li, Sohee Oh, Do Hyoung Kim, Jung Nam An, Jang-Hee Cho, Dong Ki Kim, Yong-Lim Kim, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee
Kidney Res Clin Pract. 2020;39(4):426-440.   Published online December 15, 2020
Background

The effect of each health-related quality of life (HRQOL) component on hemodialysis prognosis has not been well studied. We aimed to investigate the clinical factors associated with HRQOL and the effect of HRQOL after dialysis initiation on long-term survival in an Asian population.

Methods

A total of 568 hemodialysis patients were included from a nationwide prospective cohort study. HRQOL was...

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis
Keiji Hirai, Susumu Ookawara, Junki Morino, Saori Minato, Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Momoko Matsuyama, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichirou Ueda, Tatsuro Watano, Shinji Fujino, Kiyoka Omoto, Yoshiyuki Morishita
Kidney Res Clin Pract. 2020;39(4):441-450.   Published online September 1, 2020
Background

Few studies have investigated the relationship between serum total carbon dioxide (CO2) concentration and bicarbonate ion (HCO3-) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO2 and HCO3- concentrations and the diagnostic accuracy of serum total CO2 for the prediction of low (HCO3- < 24 mEq/L) and high (HCO3- ≥ 24 mEq/L) bicarbonate...

Customized versus conventional video counseling for peritoneal dialysis decision-making in patients with stage 5 chronic kidney disease under a PD-first policy: a randomized controlled study
Watanyu Parapiboon, Wannapat Pitsawong, Laddaporn Wongluechai, Kanin Thammavaranucupt, Lalana Raegasint
Kidney Res Clin Pract. 2020;39(4):451-459.   Published online November 13, 2020
Background

Indecision regarding the start of peritoneal dialysis (PD) is a challenging problem in chronic kidney disease (CKD) stage 5 patients who receive conventional video counseling. This study aimed to evaluate the effect of video counseling customized to the local context versus conventional video counseling on PD decision-making in CKD stage 5 patients under PD-first policy.

Methods

We enrolled 120 patients...

Clinical outcomes of infection-related hospitalization in incident peritoneal dialysis patients
Youngdong Jeon, Hyung Duk Kim, Yu Ah Hong, Hyung Wook Kim, Chul Woo Yang, Yoon-Kyung Chang, Yong Kyun Kim
Kidney Res Clin Pract. 2020;39(4):460-468.   Published online November 13, 2020
Background

Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with hemodialysis. In this study, we investigated the influence of IRH on clinical outcomes in incident PD patients.

Methods

In total, 583 incident PD patients were selected from the Clinical Research Center...

Long-term survival of children following acute peritoneal dialysis in a resource-limited setting
Michael Abel Alao, Olayinka Rasheed Ibrahim, Adanze Onyenonachi Asinobi, Akinwale Akinsola
Kidney Res Clin Pract. 2020;39(4):469-478.   Published online October 7, 2020
Background

There is a paucity of data on long term-outcomes of children who undergo acute peritoneal dialysis (PD) in resource-limited settings. We reviewed the outcomes of children who underwent PD after 18 months of follow-up.

Methods

We conducted a prospective cohort study in children with acute kidney injury (AKI) who underwent PD. Diagnosis of AKI was based on the 2012 Kidney...

The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients
Mohamed S. AbdElhalim, Ahmed S. Kenawy, Heba H. El Demellawy, Amany A. Azouz, Sarah S. Alghanem, Torki Al-Otaibi, Osama Gheith, Mohamed Abd ElMonem, Mohammed K. Afifi, Raghda R. S. Hussein
Kidney Res Clin Pract. 2020;39(4):479-486.   Published online November 20, 2020
Background

The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) may be influenced by the concomitant use of omeprazole.

Methods

One hundred kidney transplant patients were recruited during their outpatient visits, including 50 on MMF and 50 on EC-MPS. At the clinic, a predose mycophenolic acid (MPA) sample (C0) was collected; subsequently, the participants received the proton-pump inhibitor...

Pathological features and outcomes of incidental renal cell carcinoma in candidate solid organ donors
Francesca Ambrosi, Costantino Ricci, Deborah Malvi, Carlo De Cillia, Matteo Ravaioli, Michelangelo Fiorentino, Massimo Cardillo, Francesco Vasuri, Antonia D’Errico
Kidney Res Clin Pract. 2020;39(4):487-494.   Published online August 28, 2020
Background

We report the findings of a single Italian center in the evaluation of renal lesions in deceased donors from 2001 to 2017. In risk evaluation, we applied the current Italian guidelines, which include donors with small (< 4 cm, stage pT1a) renal carcinomas in the category of non-standard donors with a negligible risk of cancer transmission.

Methods

From the revision...

Remote monitoring using donor-derived, cell-free DNA after kidney transplantation during the coronavirus disease 2019 pandemic
Steven R. Potter, Randall Hinojosa, Cliff D. Miles, Dan O’Brien, David J. Ross
Kidney Res Clin Pract. 2020;39(4):495-500.   Published online December 11, 2020
Background

Donor-derived, cell-free DNA (dd-cfDNA) level correlates with allograft injury with clinical validity and utility for quiescence and active acute rejection (AR) in kidney transplant recipients. We analyzed trends in dd-cfDNA level immediately preceding and during the coronavirus disease 2019 (COVID-19) pandemic with implemented “shelter in place” and a tele-health strategy with remote home phlebotomy to limit COVID-19 exposure.

Methods

During...

Correspondence
Decline in platelet function following administration of a snake venom-derived hemocoagulase in a patient with end-stage renal disease
Byung Soo Kang, Young Il Kim, Sae-Yong Hong, Seong Su Ban, Won Seon Han, Byung Geun Kim
Kidney Res Clin Pract. 2020;39(4):501-503.   Published online November 20, 2020

Kidney Research
and
Clinical Practice

Print ISSN: 2211-9132
Online ISSN: 2211-9140


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