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Review Article
March 23, 2021
- T helper 17 cells in the pathophysiology of acute and chronic kidney disease
- David P. Basile, Md Mahbub Ullah, Jason A. Collet, et al.
- Kidney Res Clin Pract. 2021;40(1):12-28.
- Editorial
- A new opportunity for Kidney Research and Clinical Practice to make a great leap forward as a Science Citation Index Expanded journal
- Jeonghwan Lee, Sungjin Chung, Tae-Hyun Yoo
- Kidney Res Clin Pract. 2021;40(1):1-5. Published online March 30, 2021
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- Effect of volume indices of bioimpedance analysis on clinical outcomes, including left ventricular hypertrophy, in patients undergoing peritoneal dialysis
- Jun Young Do
- Kidney Res Clin Pract. 2021;40(1):6-8. Published online March 12, 2021
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- Does Th1/Th2 cell imbalance affect immunoglobulin A nephropathy?
- Tae Ryom Oh, Eun Hui Bae
- Kidney Res Clin Pract. 2021;40(1):9-11. Published online March 29, 2021
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- Review Article
- T helper 17 cells in the pathophysiology of acute and chronic kidney disease
- David P. Basile, Md Mahbub Ullah, Jason A. Collet, Purvi Mehrotra
- Kidney Res Clin Pract. 2021;40(1):12-28. Published online March 23, 2021
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Both acute and chronic kidney disease have a strong underlying inflammatory component. This review focuses primarily on T helper 17 (Th17) cells as mediators of inflammation and their potential to modulate acute and chronic kidney disease. We provide updated information on factors and signaling pathways that promote Th17 cell differentiation with specific reference to kidney disease. We highlight numerous clinical...
- A Korean perspective on the 2019 Kidney Disease Outcomes Quality Initiative guidelines for vascular access: what has changed and what should be changed in practice?
- Hyung Seok Lee, Sung Gyun Kim
- Kidney Res Clin Pract. 2021;40(1):29-39. Published online March 2, 2021
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The Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines are developed by the National Kidney Foundation in the United States; however, the guidelines have an impact on most international societies, including those in Korea. The KDOQI recently released the updated 2019 guidelines for vascular access based on numerous papers and controversies concerning vascular access since 2006, when the first guidelines were...
- Pediatric acute kidney injury: new advances in the last decade
- Sidharth K. Sethi, Timothy Bunchman, Ronith Chakraborty, Rupesh Raina
- Kidney Res Clin Pract. 2021;40(1):40-51. Published online March 3, 2021
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Pediatric acute kidney injury (AKI) is a frequently missed complication. AKI has a significant impact on both short- and long-term outcomes in children. Within the last decade, there have been major landmark developments in this field of critical care pediatric nephrology. The topic was searched by two independent researchers using Google Scholar and PubMed and related studies published in the...
- Special Article
- Trends in epidemiologic characteristics of end-stage renal disease from 2019 Korean Renal Data System (KORDS)
- Yu Ah Hong, Tae Hyun Ban, Chae-Yeong Kang, Sun Deuk Hwang, Sun Ryoung Choi, Hajeong Lee, Hee-Yeon Jung, Kyeongmin Kim, Young Eun Kwon, Su Hyun Kim, Tae Hee Kim, Ho-Seok Koo, Chang-Yun Yoon, Kiwon Kim, Jongha Park, Yong Kyun Kim
- Kidney Res Clin Pract. 2021;40(1):52-61. Published online March 25, 2021
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Background: The Korean Society of Nephrology (KSN) has maintained a nationwide end-stage renal disease (ESRD) registry data from Korean Renal Data System (KORDS) since 1985, as the representative registry of ESRD patients in Korea. This review is aimed to update the status of domestic ESRD and to provide evidence on the direction of dialysis therapy. Methods: The KORDS Committee of KSN...
- Original Article
- Comparison of chronic kidney disease trial designs and analysis strategies
- John Lawrence
- Kidney Res Clin Pract. 2021;40(1):62-68. Published online March 5, 2021
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Background: Despite the large burden of chronic kidney disease (CKD), it is challenging to conduct adequately powered clinical trials in this setting. Sound and efficient trials are needed to advance treatment. Various analysis strategies can be used to compare the efficacy of a parallel trial design with that of three two period trial designs. Methods: The type 1 error rates and...
- Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy
- Sang Youb Han, Kyung Hwan Jeong, Chun-Gyoo Ihm, Young Sun Kang, Dae Ryong Cha
- Kidney Res Clin Pract. 2021;40(1):69-76. Published online March 12, 2021
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Background: Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods: Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls...
- Histopathologic and clinicopathologic classifications of antineutrophil cytoplasmic antibody-associated glomerulonephritis: a validation study in a Korean cohort
- Jeong-Hoon Lim, Man-Hoon Han, Yong-Jin Kim, Yena Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Hajeong Lee, Dong Ki Kim, Kyung Chul Moon, Sun-Hee Park
- Kidney Res Clin Pract. 2021;40(1):77-88. Published online March 24, 2021
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Background: Antineutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AAGN) is a common cause of rapidly progressive glomerulonephritis and requires prompt and proper immunosuppressive therapy to improve renal prognosis. This study aimed to evaluate the predictive value of two different classifications for renal outcomes in Korean AAGN patients. Methods: Ninety-two patients who were diagnosed with AAGN at two tertiary hospitals between 2004 and 2018...
- The comparative effects of intravenous iron on oxidative stress and inflammation in patients with chronic kidney disease and iron deficiency: a randomized controlled pilot study
- Xenophon Kassianides, Andrew Gordon, Roger Sturmey, Sunil Bhandari
- Kidney Res Clin Pract. 2021;40(1):89-98. Published online March 22, 2021
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Background: Concerns exist regarding the pro-oxidant and inflammatory potential of intravenous (IV) iron due to labile plasma iron (LPI) generation. This IRON-CKD trial compared the effects of different IV irons on oxidative stress and inflammation. Methods: In this randomized open-label explorative single-center study in the United Kingdom, non-dialysis-dependent chronic kidney disease (CKD) patients with iron deficiency were randomized (1:1:1:1) to receive...
- Clinical outcomes among hemodialysis patients with atrial fibrillation: a Korean nationwide population-based study
- Yeunmi Kang, Hyung Yun Choi, Young Eun Kwon, Ji Hyeon Shin, Eun Mi Won, Ki Hwa Yang, Hyung Jung Oh, Dong-Ryeol Ryu
- Kidney Res Clin Pract. 2021;40(1):99-108. Published online January 14, 2021
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Background: The number of patients requiring dialysis is increasing worldwide, and the atrial fibrillation and atrial flutter (AF) prevalence among hemodialysis (HD) patients is higher than in the general population. There have been no studies of Korean AF patients undergoing HD that investigated how AF affects outcomes, such as all-cause mortality, hospitalization, and stroke events. We conducted a large-scale retrospective...
- Elevated levels of soluble ST2 but not galectin-3 are associated with increased risk of mortality in hemodialysis patients
- Ae Jin Kim, Han Ro, Hyunsook Kim, Kwang-Pil Ko, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung
- Kidney Res Clin Pract. 2021;40(1):109-119. Published online March 5, 2021
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Background: The soluble forms of suppression of tumorigenicity-2 (ST2) and galectin-3 have been proposed as novel biomarkers for cardiac fibrosis and heart failure, as well as predictors of cardiovascular events and mortality. However, there are limited data on the association between soluble ST2 and galectin-3 and clinical outcomes in patients with kidney failure on replacement therapy. To determine this, we...
- Changes in plasma sclerostin level associated with use of a medium cut-off dialyzer in end-stage renal disease
- Seon-Ho Ahn, Mi Mi Ko, Ju Hung Song, Jong Hwan Jung
- Kidney Res Clin Pract. 2021;40(1):120-134. Published online March 22, 2021
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Background: Larger middle molecules are important substances associated with cardiovascular complications in end- stage renal disease. Unfortunately, larger middle molecules are not reliably removed by a high-flux dialyzer. A medium cut-off (MCO) membrane could effectively remove larger middle molecules. This study aimed to identify the long -term effect of the MCO membrane for changes of larger middle molecules. Methods: Thirty-four patients...
- Changes in extracellular water and left ventricular mass in peritoneal dialysis patients
- Theerasak Tangwonglert, Andrew Davenport
- Kidney Res Clin Pract. 2021;40(1):135-142. Published online March 23, 2021
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Background: Increasing number of peritoneal dialysis (PD) patients are reported to have increased left ventricular hypertrophy (LVH), a major risk factor for cardiovascular mortality. We wished to determine which factors were most associated with changes in left ventricular mass index (LVMI). Methods: We reviewed patient and treatment factors in prevalent PD patients with repeat echocardiograms 18 to 24 months apart, with...
- Are there any further modalities for prediction of subclinical volume overload in advanced stages of chronic kidney disease?
- Aber Halim Baki, Cherry Reda Kamel, Hazem Mansour
- Kidney Res Clin Pract. 2021;40(1):143-152. Published online February 2, 2021
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Background: Subclinical volume overload in chronic kidney disease (CKD) patient represents a debatable issue. Although many tools were used to detect volume overload in such patients, many non-specific results were due to presence of comorbidities. Bioimpedance spectroscopy is an objective fluid status assessment method, which is shown superior to classical methods in many studies. Combining some of these tools may...
- Peripherally inserted central catheter procedure at the bedside by a nephrologist is safe and successful
- Seong Cho
- Kidney Res Clin Pract. 2021;40(1):153-161. Published online March 24, 2021
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Background: Peripherally inserted central catheter (PICC) use among critically ill patients with or without acute kidney injury (AKI) has gradually increased. Ultrasound-guided bedside PICC insertion in intensive care units (ICU) has been reported to be safe and effective. Reports of PICC insertion by a nephrologist without fluoroscopy, however, are relatively rare. Methods: This retrospective study included patients (n = 224) who...
- Impact of acute kidney injury in deceased donors with high Kidney Donor Profile Index on posttransplant clinical outcomes: a multicenter cohort study
- Woo Yeong Park, Yoon Kyung Chang, Young Soo Kim, Kyubok Jin, Chul Woo Yang, Seungyeup Han, Byung Ha Chung
- Kidney Res Clin Pract. 2021;40(1):162-174. Published online March 5, 2021
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Background: This study evaluated the impact of acute kidney injury (AKI) on posttransplant clinical outcomes for deceased donor (DD) kidney transplantation (KT) using the Kidney Donor Profile Index (KDPI) system. Methods: Overall, 657 kidney transplant recipients (KTRs) receiving kidneys from 526 DDs from four transplant centers were included. We divided them into the high and low KDPI donor groups by...
- Correspondence
- Initiating telenephrology in the coronavirus disease (COVID) era: a tertiary care experience in India
- Abhilash Chandra, Namrata Rao, Divya Srivastava
- Kidney Res Clin Pract. 2021;40(1):175-176. Published online January 21, 2021
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