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Editorial
July 3, 2026
- New strategy to regulate immunopathogenic processes of glomerulonephritis
- Ho Jun Chin
- Kidney Res Clin Pract. 2026;45(5):645-646.
- Editorials
- New strategy to regulate immunopathogenic processes of glomerulonephritis
- Ho Jun Chin
- Kidney Res Clin Pract. 2026;45(5):645-646. Published online July 3, 2026
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- The role of exercise as an adjunctive therapy in patients on maintenance hemodiafiltration: clinical benefits and implications
- Moo Jun Kim, Hyo-Wook Gil
- Kidney Res Clin Pract. 2026;45(5):647-649. Published online May 11, 2026
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- Denosumab for kidney transplant recipients: clinical value and unresolved questions
- Hye-Sun Park
- Kidney Res Clin Pract. 2026;45(5):650-652. Published online July 30, 2025
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- Special Article
- A position statement and recommendations for sustainable kidney care
- Jihyun Yang, So Mi Kim, Eunjeong Kang, Harin Rhee, Jwa-Kyung Kim, Jung-Kook Wi, Ju-Young Moon, Yoosun Joo, Yohan Park, Young-Hwan Hwang, Kyungho Choi, Younglim Kho, Katherine Barraclough, Gangjee Ko
- Kidney Res Clin Pract. 2026;45(5):653-667. Published online December 22, 2025
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The Korean Society of Nephrology has embraced the principle of “Green Nephrology” and launched campaigns addressing environmental sustainability in kidney care. These include initiatives to monitor resource usage, reduce waste generation in treatment facilities, and minimize dialysis-related environmental effects. The Society aims to raise awareness about the environmental impact of kidney disease and its treatments while emphasizing the importance of...
- Review Articles
- Advances and unmet needs in the management of proliferative lupus nephritis: evidence, guidelines, and emerging therapies
- Sunhwa Lee
- Kidney Res Clin Pract. 2026;45(5):668-676. Published online June 2, 2026
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Proliferative lupus nephritis is a major cause of kidney failure and premature mortality in patients with systemic lupus erythematosus. Although mycophenolate-based regimens and cyclophosphamide remain standard induction therapies, up to one-third of patients have refractory disease, and many fail to achieve a complete renal response, as demonstrated in the ASPREVA, AURORA, and BLISSLN trials. Treatment-related toxicity—particularly from prolonged glucocorticoid exposure—contributes...
- Evolving therapeutic landscape of immunoglobulin A nephropathy: targeted immune pathways and novel therapies
- Yaerim Kim
- Kidney Res Clin Pract. 2026;45(5):677-688. Published online July 3, 2026
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Recent advances in the understanding of immunoglobulin A nephropathy (IgAN) pathogenesis have led to a rapidly expanding therapeutic landscape for the condition. Treatments have historically relied on optimized supportive care aimed at controlling blood pressure and reducing proteinuria through blockading of the renin-angiotensin system and inhibition of the sodium glucose cotransporter 2. Growing insights into immune dysregulation, mucosal immunity, complement...
- Original Articles
- Outpatient visit intervals in chronic kidney disease: adherence to Kidney Disease: Improving Global Outcomes recommendations and determinants of variation
- Somi Kim, Ga Young Heo, Cheol Ho Park, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Song-Hee Kim, Hyung Woo Kim
- Kidney Res Clin Pract. 2026;45(5):689-701. Published online December 16, 2025
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Background: Chronic kidney disease (CKD) is a major global health problem owing to its progressive nature, complications, and substantial healthcare burden. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend outpatient visit intervals based on CKD severity; however, adherence to these recommendations and the factors influencing the visit interval remain unclear. Methods: This retrospective observational study included 13,621 patients with...
- Remission of hematuria is associated with a better prognosis in immunoglobulin A nephropathy
- Geo Neul Park, MinSung Lee, Seon Min Kim, Yoonwon Choi, Soo Jeong Choi, Moo Yong Park, Jin Kuk Kim, Byung Chul Yu
- Kidney Res Clin Pract. 2026;45(5):702-712. Published online July 3, 2026
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Background: The clinical significance of hematuria in immunoglobulin A nephropathy (IgAN) remains unclear. We defined remission of hematuria using stricter yet more intuitive criteria than those in previous studies and evaluated its association with prognosis in IgAN. Methods: This retrospective, multicenter, observational study enrolled 403 patients with IgAN. Hematuria remission was defined as hematuria persisting for at least 3 months...
- Frailty-related factors and 1-year renal function change after sodium-glucose cotransporter-2 inhibitors in elderly chronic kidney disease patients
- Hye-Mi Noh, Sei Hong Min, Hyung-Seok Lee, Sung Gyun Kim, Jun Goo Kang, Jwa-Kyung Kim
- Kidney Res Clin Pract. 2026;45(5):713-723. Published online December 8, 2025
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Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are first-line therapy for chronic kidney disease (CKD). However, evidence regarding their safety and efficacy in frail elderly patients remains limited. This study evaluated the impact of frailty-related factors on renal outcomes in elderly CKD patients treated with SGLT2i. Methods: We retrospectively analyzed 302 elderly CKD patients (≥65 years) newly prescribed SGLT2i. Four frailty-related factors...
- Development and external validation of an explainable machine learning model for predicting chronic kidney disease progression in the Korean population
- Hojun Yu, Yon Su Kim, Kwon Wook Joo, Kook-Hwan Oh, Dong Ki Kim, Hajeong Lee, Seung Seok Han, Eunjeong Kang, Sehoon Park, Byoungjun Jeon, Yong Chul Kim
- Kidney Res Clin Pract. 2026;45(5):724-742. Published online June 11, 2026
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Background: Current risk stratification models, such as the Kidney Failure Risk Equation (KFRE), exhibit variable performance across ethnic groups and fail to capture dynamic clinical trajectories. This study aimed to develop and validate a Korean-specific machine learning (ML) model for predicting chronic kidney disease (CKD) progression using an ensemble approach. Methods: We used electronic health records from Seoul National University...
- Association between obstructive sleep apnea and albuminuria in Korean adults: a nationwide populationbased study
- Yeojin Yu, Kyungdo Han, Kyu-na Lee, Jung Hun Koh, Young Sun Shin, Jeong Min Cho, Minsang Kim, Min Woo Kang, Seong Geun Kim, Sehyun Jung, Semin Cho, Hyuk Huh, Eunjeong Kang, Sehoon Park, Yaerim Kim, Kwon Wook Joo, Dong Ki Kim, Soojin Lee
- Kidney Res Clin Pract. 2026;45(5):743-753. Published online December 20, 2024
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Background: Obstructive sleep apnea (OSA) is a sleep disorder associated with an increased risk of cardiovascular and metabolic complications. Albuminuria, an early marker of kidney damage, is a proposed risk factor for OSA and its adverse outcomes. The study explored the association between OSA and albuminuria in Korean adults. Methods: We screened participants from the cross-sectional Korean National Health and...
- Exercise as an adjunctive therapy for patients on maintenance hemodiafiltration
- Jessica L. F. Andrade, Ayden T. Heitmann, Miguel K. Rodrigues, Dave K. Marchand, Adelson M. Rodrigues, Bruno P. Biluca, Rene Freitas, Thiago Reis, Miguel A. Goes, Mayron F. Oliveira
- Kidney Res Clin Pract. 2026;45(5):754-766. Published online April 25, 2025
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Background: Fatigue and sedentarism are common in kidney disease and dialysis treatment. Although hemodiafiltration effectively removes solutes and improves mortality, the influence of exercise as an adjunct therapy on maintenance hemodiafiltration programs remains understudied. Methods: A multicenter 6-month study was assessed comparing individuals with chronic kidney disease enrolled in exercise training (exercise group) during dialysis (intradialytic vs. interdialytic) compared to...
- Facility-level comorbidity burden and cardiovascular outcome in patients undergoing hemodialysis
- Hyo Jeong Kim, Seok-Jae Heo, Jung Tak Park, Ga Young Heo, Kyung Won Kim, Yong Uk Kwon, Soo Hyun Kim, Gui Ok Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Hyung Woo Kim
- Kidney Res Clin Pract. 2026;45(5):767-777. Published online March 20, 2026
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Background: The impact of facility-level comorbidity burden on the prognosis of hemodialysis patients remains unclear. This study aimed to investigate the association between facility-level comorbidity burden and hemodialysis outcomes. Methods: We examined 15,481 participants receiving hemodialysis at primary clinics participating in the Periodic Hemodialysis Quality Assessment by Health Insurance Review and Assessment Service in Korea. Facility-level comorbidity burden, defined as...
- Efficacy, safety, and dose selection of efepoetin alfa in anemic patients on maintenance dialysis: a phase 2, randomized, multicenter, active-controlled trial
- Eun Jeong Ko, Mi-Sun Byun, Chul Woo Yang, Sug Kyun Shin, Hyung Wook Kim, Byung Chul Shin, Seok Joon Shin, Hyeong Cheon Park, Young Sun Kang, Sang-Ho Lee, Ho Cheol Song, Su Hyun Kim, Ki Young Na, Young-Il Jo, Won Kim, Eun Young Seong, Yong-Lim Kim, Hyunjoo Ryu, Heewon Kim, Yoon-Jeong Choi, Byung Ha Chung
- Kidney Res Clin Pract. 2026;45(5):778-791. Published online July 8, 2026
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Background: Efepoetin alfa (GC1113, GX-E2) is a long-acting recombinant human erythropoietin fused to a hybrid fragment crystallizable (hyFc) that prolongs systemic exposure via neonatal Fc receptor-mediated recycling. This active-controlled phase 2 trial evaluated efepoetin alfa and informed phase 3 starting dose selection for chronic kidney disease-related anemia in dialysis patients. Methods: In this multicenter, open-label, active-controlled trial, adults on hemodialysis...
- Microstructural and functional connectivity changes of decision-related brain networks in end-stage kidney disease patients undergoing peritoneal dialysis
- Jingjing Yin, Dongxue Luo, Shuhua Ma, Chudan Cai, Xiaoyan Shi, Yanqiang Peng, Jianwei Peng, Lingyu Chen, Yanmin Zheng, Ruiwei Guo, Zelin Zhuang, Zhirong Lin, Lei Xie
- Kidney Res Clin Pract. 2026;45(5):792-806. Published online January 17, 2025
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Background: We aimed to explore changes in decision-related brain microstructure, brain functional activities, and functional connectivity, and their correlations with cognitive function in end-stage kidney disease (ESKD) patients undergoing peritoneal dialysis (PD). Furthermore, the impact of dialysis on these changes was examined. Methods: Thirty ESKD patients undergoing PD, 20 predialysis patients with chronic kidney disease (CKD) stage 5 (predialysis CKD...
- Xerosis elevates the risk of catheter-related infections in peritoneal dialysis patients
- Jeong Geon Lee, Jihee Lim, Nam-Jun Cho, Samel Park, Hyo-Wook Gil, Hoonhee Seo, Ho-Yeon Song, Sun-Hee Park, Kook-Hwan Oh, Yong-Lim Kim, Brian A. Bieber, Ronald L. Pisoni, Eun Young Lee
- Kidney Res Clin Pract. 2026;45(5):807-817. Published online March 25, 2026
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Background: Catheter-related infections, such as exit-site infection and tunnel infection, are major complications in peritoneal dialysis (PD) patients, affecting their prognosis. This study investigates the association between skin conditions and catheter-related infections. Methods: Data from two distinct sources were analyzed: (1) 626 PD patients in the Korean arm of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) and (2)...
- Effectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients
- Jin Kyung Kwon, Yaerim Kim, Jin Hyuk Paek, Kyubok Jin, Seungyeup Han, Woo Yeong Park
- Kidney Res Clin Pract. 2026;45(5):818-828. Published online November 18, 2024
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Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial. Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and... -
DOI: https://doi.org/10.23876/j.krcp.24.168 [Epub ahead of print]
- Combined nutcracker syndrome and glomerulonephritis in pediatric patients: a single-center retrospective case series
- So Hyun Ki, Min Hwa Son, Hyung Eun Yim
- Kidney Res Clin Pract. 2026;45(5):829-841. Published online November 29, 2024
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Background: Nutcracker syndrome (NCS) has been reported to coexist with various glomerulonephritis (GN). This study investigated clinical features of NCS combined with GN in a pediatric case series and the possible relationship between these two conditions. Methods: Clinical and pathologic findings of 15 children with NCS and biopsy-proven GN were analyzed. NCS was diagnosed with renal Doppler ultrasonography, abdominal computed...
- Images in Practice
- A hidden nonfunctioning kidney in autosomal dominant polycystic kidney disease
- Yeonsoon Jung, Ye Na Kim, Ho Sik Shin, Hark Rim
- Kidney Res Clin Pract. 2026;45(5):842-843. Published online June 17, 2026
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- Letters to the Editor
- Before new variants in genes associated with hematuria or proteinuria can be classified as causative, their pathogenicity must be demonstrated
- Sounira Mehri, Josef Finsterer
- Kidney Res Clin Pract. 2026;45(5):844-845. Published online July 28, 2026
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- Response to the letter regarding “Genetic diagnosis of hereditary kidney disease in pediatric patients through whole-exome sequencing and mitochondrial DNA analysis”
- Jiyoung Oh, Keumwha Lee, Dongju Won, Young-Mock Lee, Jae Il Shin
- Kidney Res Clin Pract. 2026;45(5):846-847. Published online August 4, 2026
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