Editorial

June 9, 2021


Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients?
Yohei Komaru, Kent Doi
Kidney Res Clin Pract. 2021;40(2):177-179.

Editorial

June 9, 2021


Biomarker for recurrent immunoglobulin A nephropathy in kidney allografts: promising but still a long way to go
Byung Ha Chung
Kidney Res Clin Pract. 2021;40(2):180-182.

Review Article

May 26, 2021


Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies
Sagar Verma, Priyanka Singh, Shiffali Khurana, et al.
Kidney Res Clin Pract. 2021;40(2):183-193.

Review Article

April 13, 2021


Extracellular vesicles in kidneys and their clinical potential in renal diseases
Sul A Lee, Chulhee Choi, Tae-Hyun Yoo
Kidney Res Clin Pract. 2021;40(2):194-207.

Original Article

May 21, 2021


Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis
Sungjin Chung, Mina Son, Yura Chae, et al.
Kidney Res Clin Pract. 2021;40(2):208-219.

Original Article

June 9, 2021


Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome
Kipyo Kim, Eunji Baek, Suryeong Go, et al.
Kidney Res Clin Pract. 2021;40(2):220-230.

Original Article

April 26, 2021


Twenty-four-hour serum creatinine variation is associated with poor outcome in the novel coronavirus disease 2019 (COVID-19) patients
Gaetano Alfano, Annachiara Ferrari, Francesco Fontana, et al.
Kidney Res Clin Pract. 2021;40(2):231-240.

Original Article

June 2, 2021


Acute kidney injury and mortality in coronavirus disease 2019: results from a cohort study of 1,280 patients
Natalia Chebotareva, Svetlana Berns, Angelina Berns, et al.
Kidney Res Clin Pract. 2021;40(2):241-249.

Original Article

May 21, 2021


Changes in metabolic parameters and adverse kidney and cardiovascular events during glomerulonephritis and renal vasculitis treatment in patients with and without diabetes mellitus
Cynthia C. Lim, Jason C. J. Choo, Hui Zhuan Tan, et al.
Kidney Res Clin Pract. 2021;40(2):250-262.

Original Article

June 2, 2021


Manifestation of rs1888747 polymorphisms in the FRMD3 gene in diabetic kidney disease and diabetic retinopathy in type 2 diabetes patients
Chatchai Kreepala, Pitirat Panpruang, Rapeeporn Yodprom, et al.
Kidney Res Clin Pract. 2021;40(2):263-271.

Original Article

May 26, 2021


Effects of residential greenness on clinical outcomes of patients with chronic kidney disease: a large-scale observation study
Jae Yoon Park, Jiyun Jung, Yong Chul Kim, et al.
Kidney Res Clin Pract. 2021;40(2):272-281.

Original Article

April 20, 2021


Causal effect of alcohol use on the risk of end-stage kidney disease and related comorbidities: a Mendelian randomization study
Sehoon Park, Soojin Lee, Yaerim Kim, et al.
Kidney Res Clin Pract. 2021;40(2):282-293.

Original Article

May 27, 2021


Age, diabetes mellitus, and dialysis modality are associated with risk of poor muscle strength and physical function in hemodialysis and peritoneal dialysis patients
Maryanne Zilli Canedo Silva, Karina Jesus Antonio, João Marcos Soares Reis, et al.
Kidney Res Clin Pract. 2021;40(2):294-303.

Original Article

April 30, 2021


Impact of high body mass index on allograft outcomes in kidney transplant recipients with presensitization to human leukocyte antigen
Yohan Park, Hanbi Lee, Eun Jeong Ko, et al.
Kidney Res Clin Pract. 2021;40(2):304-316.

Original Article

April 15, 2021


Clinical significance of serum galactose-deficient immunoglobulin A1 for detection of recurrent immunoglobulin A nephropathy in kidney transplant recipients
Woo Yeong Park, Yaerim Kim, Jin Hyuk Paek, et al.
Kidney Res Clin Pract. 2021;40(2):317-324.

Correspondence

April 14, 2021


The removal capacity of asymmetric cellulose triacetate during post-dilution online hemodiafiltration
Alba Santos, Nicolás Macías, Leonidas Cruzado, et al.
Kidney Res Clin Pract. 2021;40(2):325-327.

Review Articles
Nephrotoxicity of cancer therapeutic drugs: Focusing on novel agents
Min Hee Hong
Received February 8, 2021  Accepted May 17, 2021  
Kidney injury caused by anticancer agents is a common problem that can interfere with and affect the dose intensity of anticancer therapy, thus restricting patient survival. Recent advances in targeted and immunotherapeutic agents have transformed the landscape of medical oncology, and these agents have been widely employed in clinical practice. While typically associated with favorable toxicity profiles, several novel anticancer...
DOI: https://doi.org/10.23876/j.krcp.21.037    [Epub ahead of print]
Kidney transplantation in highly sensitized recipients
Yohan Park, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
Received January 9, 2021  Accepted March 2, 2021  
In kidney transplantation (KT), overcoming donor shortage is particularly challenging in patients with preexisting donor-specific antibodies (DSAs) against human leukocyte antigen (HLA), called HLA-incompatible KT (HLAi KT), carrying the risk of rejection and allograft loss. Thus, it is necessary to accurately evaluate the degree of sensitization before HLAi KT, and undertake appropriate pretreatment strategies. To determine the degree of sensitization,...
DOI: https://doi.org/10.23876/j.krcp.21.012    [Epub ahead of print]
Intestinal microbiota and kidney diseases
Myung-Gyu Kim, Jihyun Yang, Sang-Kyung Jo
Received March 4, 2021  Accepted April 12, 2021  
Large microbial communities reside in the gut as an endogenous organ and interact with the host physiology through symbiotic relationships, affecting health. Recent advances in high-throughput sequencing techniques have made it possible to better understand these complex microbial communities and their effects on hosts. Animal and clinical studies have provided considerable evidence to show that the microbiota plays an important...
DOI: https://doi.org/10.23876/j.krcp.21.053    [Epub ahead of print]
Original Articles
Effect of Phoxilium on prognostic predictors in patients undergoing continuous venovenous hemodiafiltration
Da Woon Kim, Hyo Jin Kim, Jin Mi Kim, You Hyun Jeon, Miyeun Han, Eun Young Seong, Sang Heon Song
Received November 12, 2020  Accepted May 11, 2021  
Background: Phoxilium is used to prevent hypophosphatemia in patients undergoing continuous venovenous hemodiafiltration (CVVHDF). This study evaluated the effect of Phoxilium on mortality in patients undergoing CVVHDF based on changes in phosphorus and red cell distribution width-coefficient of variation (RDW-CV) levels. Methods: We included 272 patients with acute kidney injury (AKI) who underwent CVVHDF at the medical intensive care unit...
DOI: https://doi.org/10.23876/j.krcp.20.217    [Epub ahead of print]
Association between copeptin levels and treatment responses to hypertonic saline infusion in patients with symptomatic hyponatremia: a prospective cohort study
Suryeong Go, Sejoong Kim, Hyung-Eun Son, Ji-Young Ryu, Huijin Yang, Sun Ryoung Choi, Jang-Won Seo, You Hwan Jo, Ja-Ryong Koo, Seon Ha Baek
Received November 23, 2020  Accepted April 28, 2021  
Background: Copeptin is secreted in equimolar amounts as arginine vasopressin, main hormone regulating body fluid homeostasis. A recent study reported a copeptin-based classification of osmoregulatory defects in syndromes of inappropriate antidiuresis that may aid in prediction of therapeutic success. We investigated usefulness of copeptin for differentiating etiologies of hyponatremia and predicting efficacy and safety of hypertonic saline treatment in hyponatremic...
DOI: https://doi.org/10.23876/j.krcp.20.233    [Epub ahead of print]
Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea
Nam-Jun Cho, Dae-Yeon Kim, Soon Hyo Kwon, Tae Won Ha, Hyun Kyu Kim, Man Ryul Lee, Sung Wan Chun, Samel Park, Eun-young Lee, Hyo-Wook Gil
Received January 12, 2021  Accepted May 13, 2021  
Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidiabetic agents prevent diabetic kidney disease progression, it is important to investigate their effect on the kidney environment in type 2 diabetes mellitus (DM) patients. Herein, we investigated the expression pattern of urinary exosome-derived microRNA (miRNA) in patients taking a combination of DPP-4 inhibitor and...
DOI: https://doi.org/10.23876/j.krcp.21.015    [Epub ahead of print]
Mortality predictors in critically ill patients with acute kidney injury requiring continuous renal replacement therapy
Kristianne Rachel P. Medina-Liabres, Jong Cheol Jeong, Hyung Jung Oh, Jung Nam An, Jung Pyo Lee, Dong Ki Kim, Dong-Ryeol Ryu, Sejoong Kim
Received October 28, 2020  Accepted March 7, 2021  
Background: Because of high cost of continuous renal replacement therapy (CRRT) and the high mortality rate among severe acute kidney injury patients, careful identification of patients who will benefit from CRRT is warranted. This study determined factors associated with mortality among critically ill patients requiring CRRT. Methods: This was a retrospective observational study of 414 patients admitted to the intensive...
DOI: https://doi.org/10.23876/j.krcp.20.205    [Epub ahead of print]
Blood pressure prior to percutaneous coronary intervention is associated with the risk of end-stage renal disease: a nationwide population based-cohort study
Eun Hui Bae, Sang Yup Lim, Bongseong Kim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
Received December 2, 2020  Accepted April 21, 2021  
Background: Hypertension is the most important modifiable risk factor for mortality and morbidity in chronic kidney disease and coronary artery syndrome. The effect of hypertension prior to percutaneous coronary intervention (PCI) on the development of end-stage renal disease (ESRD) is unknown. Methods: We used nationally representative data from the Korean National Health Insurance System—140,164 subjects were enrolled during 2010–2015; they...
DOI: https://doi.org/10.23876/j.krcp.21.245    [Epub ahead of print]
Evolving outcomes of peritoneal dialysis: secular trends at a single large center over three decades
Minjung Kang, Yae Lim Kim, Eunjeong Kang, Hyunjin Ryu, Yong Chul Kim, Dong Ki Kim, Hajeong Lee, Seung Seok Han, Kwon-Wook Joo, Yon Su Kim, Curie Ahn, Kook-Hwan Oh
Received January 25, 2021  Accepted April 24, 2021  
Background: Peritoneal dialysis (PD) is improving as a renal replacement therapy for end-stage renal disease (ESRD) patients. We analyzed the main outcomes of PD over the last three decades at a single large-scale PD center with an established high-quality care system. Methods: As a retrospective cohort study, we included participants (n = 1,203) who began PD between 1990 and 2019....
DOI: https://doi.org/10.23876/j.krcp.21.020    [Epub ahead of print]
Comparison of normal saline solution with low-chloride solutions in renal transplants: a meta-analysis
Abdullah Jahangir, Syeda Sahra, Muhammad Rafay Khan Niazi, Fasih Sami Siddiqui, Muhammad Yasir Anwar, Ahmad Jahangir, Elie J El-Charabaty
Received February 4, 2021  Accepted April 25, 2021  
Background: Normal saline solution (NSS) has been the fluid of choice for renal transplant patients, but it can lead to hyperchloremic acidosis and hyperkalemia. This study was performed to compare the safety profile of low-chloride solutions with that of NSS in renal transplant patients. Methods: We conducted a systemic review search on PubMed, Embase, and the Central Cochrane Registry. Randomized clinical...
DOI: https://doi.org/10.23876/j.krcp.21.027    [Epub ahead of print]
Effect of pravastatin on erythrocyte membrane fatty acid contents in patients with chronic kidney disease
Su Mi Lee, Young Ki Son, Seong Eun Kim, Yeong Hoon Kim, Yongsoon Park, Won Suk An
Received December 4, 2020  Accepted March 21, 2021  
Background: Statin treatment has decreased the risk of cardiovascular events in patients with chronic kidney disease (CKD). Erythrocyte membrane oleic acid level is higher in patients with acute coronary syndrome. This study aimed to evaluate the effect of pravastatin on the erythrocyte membrane fatty acid (FA) contents in patients with CKD. Methods: Sixty-two patients were enrolled from January 2017 to March...
DOI: https://doi.org/10.23876/j.krcp.20.247    [Epub ahead of print]

Kidney Research
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