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Editorial
June 9, 2021
- Does a slight change in serum creatinine matter in coronavirus disease 2019 (COVID-19) patients?
- Yohei Komaru, Kent Doi
- Kidney Res Clin Pract. 2021;40(2):177-179.
- Review Articles
- Nephrotoxicity of cancer therapeutic drugs: Focusing on novel agents
- Min Hee Hong
- Received February 8, 2021 Accepted May 17, 2021
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Kidney injury caused by anticancer agents is a common problem that can interfere with and affect the dose intensity of anticancer therapy, thus restricting patient survival. Recent advances in targeted and immunotherapeutic agents have transformed the landscape of medical oncology, and these agents have been widely employed in clinical practice. While typically associated with favorable toxicity profiles, several novel anticancer... -
DOI: https://doi.org/10.23876/j.krcp.21.037 [Epub ahead of print]
- Kidney transplantation in highly sensitized recipients
- Yohan Park, Eun Jeong Ko, Byung Ha Chung, Chul Woo Yang
- Received January 9, 2021 Accepted March 2, 2021
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In kidney transplantation (KT), overcoming donor shortage is particularly challenging in patients with preexisting donor-specific antibodies (DSAs) against human leukocyte antigen (HLA), called HLA-incompatible KT (HLAi KT), carrying the risk of rejection and allograft loss. Thus, it is necessary to accurately evaluate the degree of sensitization before HLAi KT, and undertake appropriate pretreatment strategies. To determine the degree of sensitization,... -
DOI: https://doi.org/10.23876/j.krcp.21.012 [Epub ahead of print]
- Intestinal microbiota and kidney diseases
- Myung-Gyu Kim, Jihyun Yang, Sang-Kyung Jo
- Received March 4, 2021 Accepted April 12, 2021
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Large microbial communities reside in the gut as an endogenous organ and interact with the host physiology through symbiotic relationships, affecting health. Recent advances in high-throughput sequencing techniques have made it possible to better understand these complex microbial communities and their effects on hosts. Animal and clinical studies have provided considerable evidence to show that the microbiota plays an important... -
DOI: https://doi.org/10.23876/j.krcp.21.053 [Epub ahead of print]
- Original Articles
- Effect of Phoxilium on prognostic predictors in patients undergoing continuous venovenous hemodiafiltration
- Da Woon Kim, Hyo Jin Kim, Jin Mi Kim, You Hyun Jeon, Miyeun Han, Eun Young Seong, Sang Heon Song
- Received November 12, 2020 Accepted May 11, 2021
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Background: Phoxilium is used to prevent hypophosphatemia in patients undergoing continuous venovenous hemodiafiltration (CVVHDF). This study evaluated the effect of Phoxilium on mortality in patients undergoing CVVHDF based on changes in phosphorus and red cell distribution width-coefficient of variation (RDW-CV) levels. Methods: We included 272 patients with acute kidney injury (AKI) who underwent CVVHDF at the medical intensive care unit... -
DOI: https://doi.org/10.23876/j.krcp.20.217 [Epub ahead of print]
- Association between copeptin levels and treatment responses to hypertonic saline infusion in patients with symptomatic hyponatremia: a prospective cohort study
- Suryeong Go, Sejoong Kim, Hyung-Eun Son, Ji-Young Ryu, Huijin Yang, Sun Ryoung Choi, Jang-Won Seo, You Hwan Jo, Ja-Ryong Koo, Seon Ha Baek
- Received November 23, 2020 Accepted April 28, 2021
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Background: Copeptin is secreted in equimolar amounts as arginine vasopressin, main hormone regulating body fluid homeostasis. A recent study reported a copeptin-based classification of osmoregulatory defects in syndromes of inappropriate antidiuresis that may aid in prediction of therapeutic success. We investigated usefulness of copeptin for differentiating etiologies of hyponatremia and predicting efficacy and safety of hypertonic saline treatment in hyponatremic... -
DOI: https://doi.org/10.23876/j.krcp.20.233 [Epub ahead of print]
- Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea
- Nam-Jun Cho, Dae-Yeon Kim, Soon Hyo Kwon, Tae Won Ha, Hyun Kyu Kim, Man Ryul Lee, Sung Wan Chun, Samel Park, Eun-young Lee, Hyo-Wook Gil
- Received January 12, 2021 Accepted May 13, 2021
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Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidiabetic agents prevent diabetic kidney disease progression, it is important to investigate their effect on the kidney environment in type 2 diabetes mellitus (DM) patients. Herein, we investigated the expression pattern of urinary exosome-derived microRNA (miRNA) in patients taking a combination of DPP-4 inhibitor and... -
DOI: https://doi.org/10.23876/j.krcp.21.015 [Epub ahead of print]
- Mortality predictors in critically ill patients with acute kidney injury requiring continuous renal replacement therapy
- Kristianne Rachel P. Medina-Liabres, Jong Cheol Jeong, Hyung Jung Oh, Jung Nam An, Jung Pyo Lee, Dong Ki Kim, Dong-Ryeol Ryu, Sejoong Kim
- Received October 28, 2020 Accepted March 7, 2021
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Background: Because of high cost of continuous renal replacement therapy (CRRT) and the high mortality rate among severe acute kidney injury patients, careful identification of patients who will benefit from CRRT is warranted. This study determined factors associated with mortality among critically ill patients requiring CRRT. Methods: This was a retrospective observational study of 414 patients admitted to the intensive... -
DOI: https://doi.org/10.23876/j.krcp.20.205 [Epub ahead of print]
- Blood pressure prior to percutaneous coronary intervention is associated with the risk of end-stage renal disease: a nationwide population based-cohort study
- Eun Hui Bae, Sang Yup Lim, Bongseong Kim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
- Received December 2, 2020 Accepted April 21, 2021
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Background: Hypertension is the most important modifiable risk factor for mortality and morbidity in chronic kidney disease and coronary artery syndrome. The effect of hypertension prior to percutaneous coronary intervention (PCI) on the development of end-stage renal disease (ESRD) is unknown. Methods: We used nationally representative data from the Korean National Health Insurance System—140,164 subjects were enrolled during 2010–2015; they... -
DOI: https://doi.org/10.23876/j.krcp.21.245 [Epub ahead of print]
- Evolving outcomes of peritoneal dialysis: secular trends at a single large center over three decades
- Minjung Kang, Yae Lim Kim, Eunjeong Kang, Hyunjin Ryu, Yong Chul Kim, Dong Ki Kim, Hajeong Lee, Seung Seok Han, Kwon-Wook Joo, Yon Su Kim, Curie Ahn, Kook-Hwan Oh
- Received January 25, 2021 Accepted April 24, 2021
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Background: Peritoneal dialysis (PD) is improving as a renal replacement therapy for end-stage renal disease (ESRD) patients. We analyzed the main outcomes of PD over the last three decades at a single large-scale PD center with an established high-quality care system. Methods: As a retrospective cohort study, we included participants (n = 1,203) who began PD between 1990 and 2019.... -
DOI: https://doi.org/10.23876/j.krcp.21.020 [Epub ahead of print]
- Comparison of normal saline solution with low-chloride solutions in renal transplants: a meta-analysis
- Abdullah Jahangir, Syeda Sahra, Muhammad Rafay Khan Niazi, Fasih Sami Siddiqui, Muhammad Yasir Anwar, Ahmad Jahangir, Elie J El-Charabaty
- Received February 4, 2021 Accepted April 25, 2021
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Background: Normal saline solution (NSS) has been the fluid of choice for renal transplant patients, but it can lead to hyperchloremic acidosis and hyperkalemia. This study was performed to compare the safety profile of low-chloride solutions with that of NSS in renal transplant patients. Methods: We conducted a systemic review search on PubMed, Embase, and the Central Cochrane Registry. Randomized clinical... -
DOI: https://doi.org/10.23876/j.krcp.21.027 [Epub ahead of print]
- Effect of pravastatin on erythrocyte membrane fatty acid contents in patients with chronic kidney disease
- Su Mi Lee, Young Ki Son, Seong Eun Kim, Yeong Hoon Kim, Yongsoon Park, Won Suk An
- Received December 4, 2020 Accepted March 21, 2021
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Background: Statin treatment has decreased the risk of cardiovascular events in patients with chronic kidney disease (CKD). Erythrocyte membrane oleic acid level is higher in patients with acute coronary syndrome. This study aimed to evaluate the effect of pravastatin on the erythrocyte membrane fatty acid (FA) contents in patients with CKD. Methods: Sixty-two patients were enrolled from January 2017 to March... -
DOI: https://doi.org/10.23876/j.krcp.20.247 [Epub ahead of print]
