Editorial

May 9, 2022


Alkali therapy for prevention of acute kidney injury in rhabdomyolysis
Jun-Ya Kaimori, Yusuke Sakaguchi, Yoshitaka Isaka
Kidney Res Clin Pract. 2022;41(5):521-523.

Review Article

June 21, 2022


A new pathological perspective on thrombotic microangiopathy
Yong-Jin Kim
Kidney Res Clin Pract. 2022;41(5):524-532.

Review Article

September 30, 2022


Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies
Verdiana Ravarotto, Giovanni Bertoldi, Lucia Federica Stefanelli, et al.
Kidney Res Clin Pract. 2022;41(5):533-544.

Original Article

September 30, 2022


Pathological validation of the Japanese Renal Pathology Society classification and challenges in predicting renal prognosis in patients with diabetic nephropathy
Taeyeong Kim, Yooujin Kwak, Jun Young Lee, et al.
Kidney Res Clin Pract. 2022;41(5):545-555.

Original Article

May 4, 2022


External validation of the international prediction tool in Korean patients with immunoglobulin A nephropathy
Young Su Joo, Hyung Woo Kim, Chung Hee Baek, et al.
Kidney Res Clin Pract. 2022;41(5):556-566.

Original Article

May 4, 2022


Albuminuria, estimated glomerular filtration rate, and traditional predictors for composite cardiovascular and kidney outcome: a population-based cohort study in Korea
Hae Hyuk Jung
Kidney Res Clin Pract. 2022;41(5):567-579.

Original Article

June 24, 2022


Serum cystatin C to creatinine ratio is associated with sarcopenia in non-dialysis-dependent chronic kidney disease
Jung Nam An, Jwa-Kyung Kim, Hyung-Seok Lee, et al.
Kidney Res Clin Pract. 2022;41(5):580-590.

Original Article

June 21, 2022


COVID-19–related clinical outcomes among Korean hemodialysis patients
Hayne Cho Park, Young-Ki Lee, Eunsil Ko, et al.
Kidney Res Clin Pract. 2022;41(5):591-600.

Original Article

May 4, 2022


Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs
Hyuk Huh, Ejin Kim, Una Amelia Yoon, et al.
Kidney Res Clin Pract. 2022;41(5):601-610.

Original Article

May 11, 2022


The importance of muscle mass in predicting intradialytic hypotension in patients undergoing maintenance hemodialysis
Hyung Eun Son, Ji Young Ryu, Kyunghoon Lee, et al.
Kidney Res Clin Pract. 2022;41(5):611-622.

Original Article

July 21, 2022


Antithymocyte globulin versus basiliximab induction for kidney transplantation in elderly patients: matched analysis within the Korean multicentric registry
Jun Young Lee, Sung Hwa Kim, Yeon Ho Park, et al.
Kidney Res Clin Pract. 2022;41(5):623-634.

Images in Pratice

September 22, 2022


Ureteral stent infection caused by Candida in a renal transplant recipient
Haeun Lee, Byung Ha Chung, Chul Woo Yang, et al.
Kidney Res Clin Pract. 2022;41(5):635-636.

Review Articles
Advances in the management of diabetic kidney disease: beyond sodium-glucose co-transporter 2 inhibitors
Anthony T.P. Chan, Sydney C.W. Tang
Received November 30, 2021  Accepted May 9, 2022  
Progress in the treatment of diabetic kidney disease (DKD) has been modest since the early trials on renin-angiotensin-aldosterone system inhibitors (RAASis). Although sodium-glucose co-transporter 2 inhibitors (SGLT2is) have revolutionized the management of DKD by lowering proteinuria and protecting organs, other novel treatment approaches with good evidence and efficacy that can be used in conjunction with a RAASi or SGLT2i in...
DOI: https://doi.org/10.23876/j.krcp.21.285    [Epub ahead of print]
Recent advances in electron microscopy for the diagnosis and research of glomerular diseases
Kazuho Honda, Takashi Takaki, Dedong Kang
Received November 19, 2021  Accepted December 26, 2021  
Recent technical advances in the detection of backscattered electrons during scanning electron microscopy (SEM) have improved resolution and have provided several new technologies for research and clinical practice in kidney disease. The advances include three-dimensional (3D) electron microscopy (3D-EM), correlative light and electron microscopy (CLEM), low-vacuum SEM (LVSEM), and scanning transmission electron microscopy (STEM). 3D-EM analysis used to be laborious,...
DOI: https://doi.org/10.23876/j.krcp.21.270    [Epub ahead of print]
Uremic pruritus: pathophysiology, clinical presentation, and treatments
Mei-Ju Ko, Yu-Sen Peng, Hon-Yen Wu
Received August 30, 2021  Accepted December 25, 2021  
Uremic pruritus is one of the most common and bothersome symptoms in patients with end-stage renal disease. Most patients with uremic pruritus experience a prolonged and relapsing course and significant impairments of quality of life. The pathophysiology of uremic pruritus is not completely understood. A complex interplay among cutaneous biology and the nervous and immune systems has been implicated, with...
DOI: https://doi.org/10.23876/j.krcp.21.189    [Epub ahead of print]
Why should we focus on high-volume hemodiafiltration?
Sug-Kyun Shin, Young-Il Jo
Received November 14, 2021  Accepted December 23, 2021  
Though noticeable technological advances related to hemodialysis (HD) have been made, unfortunately, the survival rate of dialysis patients has yet to improve significantly. However, recent research findings reveal that online hemodiafiltration (HDF) significantly improves patient survival in comparison to conventional HD. Accordingly, the number of patients receiving online HDF is increasing. Although the mechanism driving the benefit has not yet...
DOI: https://doi.org/10.23876/j.krcp.21.268    [Epub ahead of print]
Nutrition and quality of life in chronic kidney disease patients: a practical approach for salt restriction
Kunitoshi Iseki
Received September 11, 2021  Accepted October 25, 2021  
The clinical practice guidelines (CPGs) for nutrition in chronic kidney disease (CKD) were updated after 20 years from the previous guidelines by the Kidney Disease Outcomes Quality Initiative (KDOQI). During this period, the severity of CKD was defined by estimated glomerular filtration rate and albuminuria by the organization Kidney Disease: Improving Global Outcomes. Main risk factors for CKD such as...
DOI: https://doi.org/10.23876/j.krcp.21.203    [Epub ahead of print]
Original Articles
Optimal peritoneal fluid white blood cell count for diagnosis of peritonitis in peritoneal dialysis patients
Margarita Kunin, Sharon Mini, Nabil Abu-Amer, Pazit Beckerman
Received October 29, 2021  Accepted May 7, 2022  
Background: The diagnosis of peritonitis among peritoneal dialysis (PD) patients is based on clinical presentation, dialysis effluent white blood cell (WBC) count, and dialysis effluent culture. Peritoneal fluid WBC count is very important in the initial diagnosis of peritonitis. The purpose of this work was to determine the optimal number of peritoneal WBCs with different clinical presentations at admission to...
DOI: https://doi.org/10.23876/j.krcp.21.254    [Epub ahead of print]
Hemodialysis facility star rating affects mortality in chronic hemodialysis patients: a longitudinal observational cohort study
Hayne Cho Park, Hyung Yun Choi, Do Hyoung Kim, AJin Cho, Young Eun Kwon, Dong-Ryeol Ryu, Ki Hwa Yang, Eun Mi Won, Ji Hyeon Shin, Jinseog Kim, Young-Ki Lee
Received February 22, 2022  Accepted May 16, 2022  
Background: Many countries have their own hemodialysis (HD) quality assurance programs and star rating systems for HD facilities. However, the effects of HD quality assurance programs on patient mortality are not well understood. Therefore, in the present study, the effects of the Korean HD facility star rating on patient mortality in maintenance HD patients were evaluated. Methods: This longitudinal, observational...
DOI: https://doi.org/10.23876/j.krcp.22.039    [Epub ahead of print]
Deep learning predicts the differentiation of kidney organoids derived from human induced pluripotent stem cells
Keonhyeok Park, Jong Young Lee, Soo Young Lee, Iljoo Jeong, Seo-Yeon Park, Jin Won Kim, Sun Ah Nam, Hyung Wook Kim, Yong Kyun Kim, Seungchul Lee
Received January 27, 2022  Accepted May 2, 2022  
Background: Kidney organoids derived from human pluripotent stem cells (hPSCs) contain multilineage nephrogenic progenitor cells and can recapitulate the development of the kidney. Kidney organoids derived from hPSCs have the potential to be applied in regenerative medicine as well as renal disease modeling, drug screening, and nephrotoxicity testing. Despite biotechnological advances, individual differences in morphological and growth characteristics among kidney...
DOI: https://doi.org/10.23876/j.krcp.22.017    [Epub ahead of print]
Associations among Alzheimer disease, depressive disorder, and risk of end-stage kidney disease in elderly people
Shin Chan Kang, Hee Byung Koh, Hyung Woo Kim, Young Su Joo, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Received December 29, 2021  Accepted May 1, 2022  
Background: Alzheimer disease (AD) and depressive disorder (DD) are prevalent among elderly end-stage kidney disease (ESKD) patients. However, whether preexisting mental health disorders increase the risk of ESKD is not well understood. The risk of incident ESKD in patients with or without underlying AD or DD was evaluated in a nationwide cohort of elderly people in Republic of Korea. Methods: This...
DOI: https://doi.org/10.23876/j.krcp.21.311    [Epub ahead of print]
Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study
Hong Sang Choi, Bongseong Kim, Kyung-Do Han, Tae Ryom Oh, Sang Heon Suh, Minah Kim, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Received December 8, 2021  Accepted May 10, 2022  
Background: Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD). Methods: From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weight data from two...
DOI: https://doi.org/10.23876/j.krcp.21.294    [Epub ahead of print]
Distribution of pathological types and epidemiological characteristics based on kidney biopsy in Northwest China
Yunlong Qin, Jin Zhao, Xiao Wei, Yuwei Wang, Zixian Yu, Yumeng Zhang, Shiren Sun
Received December 13, 2021  Accepted May 6, 2022  
Background: The spectrum of biopsy-confirmed kidney disease varies with regions and periods. We describe the distribution of pathological types and epidemiological characteristics of kidney diseases in Northwest China due to regional differences in geographical environment, social economy, and dietary habits. Methods: Kidney biopsy cases from 2005 to 2020 in Xijing Hospital were retrospectively analyzed. Pathological characteristics of patients in different...
DOI: https://doi.org/10.23876/j.krcp.21.296    [Epub ahead of print]
Nitric oxide-inhibited chloride transport in cortical thick ascending limbs is reversed by 8-iso-prostaglandin-F2α
Pablo D. Cabral, Guillermo B. Silva, Sandra T. Baigorria, Luis I. Juncos, Ebenezer I. O. Ajayi, Néstor H. García
Received October 22, 2021  Accepted April 11, 2022  
Background: Salt reabsorption in the cortical thick ascending limb (cTAL) is regulated by opposing effects. Thus, while nitric oxide (NO) inhibits sodium chloride (NaCl) reabsorption, 8-iso-prostaglandin-F2α (8-iso-PGF2α) stimulates it. Their interaction, however, has not been evaluated in the cTAL. Because 8-iso-PGF2α has considerable stability while NO is a free radical with a short half-life, we hypothesized that, in the cTAL,...
DOI: https://doi.org/10.23876/j.krcp.21.243    [Epub ahead of print]
Hospital mortality and prognostic factors in critically ill patients with acute kidney injury and cancer undergoing continuous renal replacement therapy
Da Woon Kim, Geum Suk Jang, Kyoung Suk Jung, Hyuk Jae Jung, Hyo Jin Kim, Harin Rhee, Eun Young Seong, Sang Heon Song
Received December 24, 2021  Accepted April 25, 2022  
Background: Whether continuous renal replacement therapy (CRRT) should be applied to critically ill patients with both acute kidney injury (AKI) and cancer remains controversial because of poor expected outcomes. The present study determined prognostic factors for all-cause in-hospital mortality in patients with AKI and cancer undergoing CRRT. Methods: We included 471 patients with AKI and cancer who underwent CRRT at the...
DOI: https://doi.org/10.23876/j.krcp.21.305    [Epub ahead of print]
Association of sarcopenia and its components with clinical outcomes in patients undergoing peritoneal dialysis
Seok Hui Kang, A Young Kim, Jun Young Do
Received November 21, 2021  Accepted April 20, 2022  
Background: Further studies are needed to identify whether muscle mass, muscle strength, or sarcopenia is the best indicator of survival in patients undergoing peritoneal dialysis (PD). We aimed to compare the association of sarcopenia and its components with survival in patients undergoing PD. Methods: We identified all patients with prevalent PD (n = 199). We routinely recommended handgrip strength (HGS) and...
DOI: https://doi.org/10.23876/j.krcp.21.278    [Epub ahead of print]
Clinical relevance of postoperative proteinuria for prediction of early renal outcomes after kidney transplantation
Junseok Jun, Kyungho Park, Hyun Suk Lee, Kyo Won Lee, Jung Eun Lee, Jae Berm Park, Kyunga Kim, Wooseong Huh, Yoon-Goo Kim, Dae Joong Kim, Hye Ryoun Jang
Received October 27, 2021  Accepted April 18, 2022  
Background: Proteinuria is associated with poor allograft and patient survival in kidney transplant recipients. However, the clinical relevance of spot urine protein-to-creatinine ratio (PCR) or albumin-to-creatinine ratio (ACR) as predictors of renal outcomes during the early postoperative period following kidney transplantation (KT) has not been determined. Methods: This single-center retrospective cohort study included 353 kidney transplant recipients who underwent KT...
DOI: https://doi.org/10.23876/j.krcp.21.246    [Epub ahead of print]
Identification of osteopontin as a urinary biomarker for autosomal dominant polycystic kidney disease progression
Hyunsuk Kim, Jinmo Sung, Ju Young Bae, Poongyeon Lee, Yun Kyu Oh, Hyunho Kim
Received December 25, 2021  Accepted April 21, 2022  
Background: Autosomal dominant polycystic kidney disease (ADPKD), one of the most common human monogenic diseases, is characterized by the presence of numerous fluid-filled renal cysts and is a leading cause of end-stage renal disease (ESRD). Urinary biomarkers may be useful for predicting the variable course of ADPKD progression from cyst growth to ESRD. Methods: To identify candidate urinary biomarkers of ADPKD...
DOI: https://doi.org/10.23876/j.krcp.21.303    [Epub ahead of print]

Kidney Research
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