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Editorial
January 21, 2022
- The importance of psychiatric disorders in end-stage kidney disease patients
- Eun Lee
- Kidney Res Clin Pract. 2022;41(2):133-135.
- Study Protocol
- Efficacy and safety of rapid intermittent bolus compared with slow continuous infusion in patients with severe hypernatremia (SALSA II trial): a study protocol for a randomized controlled trial
- Ji Young Ryu, Songuk Yoon, Jeonghwan Lee, Sumin Baek, You Hwan Jo, Kwang-Pil Ko, Jin-ah Sim, Junhee Han, Sejoong Kim, Seon Ha Baek
- Received September 1, 2021 Accepted November 22, 2021
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Background: Hypernatremia is a common electrolyte disorder in children and elderly people and has high short-term mortality. However, no high-quality studies have examined the correction rate of hypernatremia and the amount of fluid required for correction. Therefore, in this study, we will compare the efficacy and safety of rapid intermittent bolus (RIB) and slow continuous infusion (SCI) of electrolyte-free solution... -
DOI: https://doi.org/10.23876/j.krcp.21.193 [Epub ahead of print]
- Editorials
- Alkali therapy for prevention of acute kidney injury in rhabdomyolysis
- Jun-Ya Kaimori, Yusuke Sakaguchi, Yoshitaka Isaka
- Received March 7, 2022 Accepted March 8, 2022
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DOI: https://doi.org/10.23876/j.krcp.22.044 [Epub ahead of print]
- Overcorrection versus osmotic demyelination syndrome: what should we watch out for during management of symptomatic chronic hyponatremia?
- Hyun Lee Ko, Sung Woo Lee
- Received February 14, 2022 Accepted February 28, 2022
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DOI: https://doi.org/10.23876/j.krcp.22.032 [Epub ahead of print]
- Are older adults safe and suitable candidate donors or recipients for kidney transplantation?
- Yu Ah Hong
- Received February 13, 2022 Accepted February 23, 2022
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DOI: https://doi.org/10.23876/j.krcp.22.028 [Epub ahead of print]
- Review Articles
- Recent advances in electron microscopy for the diagnosis and research of glomerular diseases
- Kazuho Honda, Takashi Takaki, Dedong Kang
- Received November 19, 2021 Accepted December 26, 2021
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Recent technical advances in the detection of backscattered electrons during scanning electron microscopy (SEM) have improved resolution and have provided several new technologies for research and clinical practice in kidney disease. The advances include three-dimensional (3D) electron microscopy (3D-EM), correlative light and electron microscopy (CLEM), low-vacuum SEM (LVSEM), and scanning transmission electron microscopy (STEM). 3D-EM analysis used to be laborious,... -
DOI: https://doi.org/10.23876/j.krcp.21.270 [Epub ahead of print]
- Uremic pruritus: pathophysiology, clinical presentation, and treatments
- Mei-Ju Ko, Yu-Sen Peng, Hon-Yen Wu
- Received August 30, 2021 Accepted December 25, 2021
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Uremic pruritus is one of the most common and bothersome symptoms in patients with end-stage renal disease. Most patients with uremic pruritus experience a prolonged and relapsing course and significant impairments of quality of life. The pathophysiology of uremic pruritus is not completely understood. A complex interplay among cutaneous biology and the nervous and immune systems has been implicated, with... -
DOI: https://doi.org/10.23876/j.krcp.21.189 [Epub ahead of print]
- Management of autosomal dominant polycystic kidney disease in the era of disease-modifying treatment options
- Yeshwanter Radhakrishnan, Parikshit Duriseti, Fouad T. Chebib
- Received December 29, 2021 Accepted February 14, 2022
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Autosomal dominant polycystic kidney disease (ADPKD) is the reported etiology in 10% of end-stage kidney disease (ESKD) patients and has an estimated prevalence of 12.5 million cases worldwide across all ethnicities. There have been major advancements over the last two decades in understanding the pathogenesis and development of disease-modifying treatment options for ADPKD, culminating in regulatory approval of tolvaptan for... -
DOI: https://doi.org/10.23876/j.krcp.21.309 [Epub ahead of print]
- Claudins in kidney health and disease
- Chor ho Jo, Sua Kim, Gheun-Ho Kim
- Received November 22, 2021 Accepted December 29, 2021
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Claudins are strategically located to exert their physiologic actions along with the nephron segments from the glomerulus. Claudin-1 is normally located in the Bowman’s capsule, but its overexpression can reach the podocytes and lead to albuminuria. In the proximal tubule (PT), claudin-2 forms paracellular channels selective for water, Na+ , K+ , and Ca2+. Claudin-2 gene mutations are associated with... -
DOI: https://doi.org/10.23876/j.krcp.21.279 [Epub ahead of print]
- Exploring molecular targets in diabetic kidney disease
- Sayako Maruno, Tetsuhiro Tanaka, Masaomi Nangaku
- Received October 29, 2021 Accepted January 13, 2022
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Diabetic kidney disease is the leading cause of end-stage kidney disease, and it remains a major challenge. Many factors, such as glomerular hyperfiltration, oxidative stress, inflammation, hypoxia, and epigenetics, are associated with the progression of diabetic kidney disease; however, the whole mechanism is not yet completely understood. No specific treatment for diabetic kidney disease has been established, so new approaches... -
DOI: https://doi.org/10.23876/j.krcp.21.251 [Epub ahead of print]
- Application of C5 inhibitors in glomerular diseases in 2021
- Alexis Werion, Eric Rondeau
- Received October 26, 2021 Accepted January 17, 2022
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The complement pathway is an essential mechanism in innate immunity, but it is also involved in multiple pathologies. For kidney diseases, strong evidence of a dysregulation in the alternative pathway in atypical hemolytic uremic syndrome (aHUS) led to the use of eculizumab, the first anti-C5 inhibitor available in clinical practice. Intensive fundamental research resulted in the development of subsequent new... -
DOI: https://doi.org/10.23876/j.krcp.21.248 [Epub ahead of print]
- Why should we focus on high-volume hemodiafiltration?
- Sug-Kyun Shin, Young-Il Jo
- Received November 14, 2021 Accepted December 23, 2021
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Though noticeable technological advances related to hemodialysis (HD) have been made, unfortunately, the survival rate of dialysis patients has yet to improve significantly. However, recent research findings reveal that online hemodiafiltration (HDF) significantly improves patient survival in comparison to conventional HD. Accordingly, the number of patients receiving online HDF is increasing. Although the mechanism driving the benefit has not yet... -
DOI: https://doi.org/10.23876/j.krcp.21.268 [Epub ahead of print]
- Nutrition and quality of life in chronic kidney disease patients: a practical approach for salt restriction
- Kunitoshi Iseki
- Received September 11, 2021 Accepted October 25, 2021
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The clinical practice guidelines (CPGs) for nutrition in chronic kidney disease (CKD) were updated after 20 years from the previous guidelines by the Kidney Disease Outcomes Quality Initiative (KDOQI). During this period, the severity of CKD was defined by estimated glomerular filtration rate and albuminuria by the organization Kidney Disease: Improving Global Outcomes. Main risk factors for CKD such as... -
DOI: https://doi.org/10.23876/j.krcp.21.203 [Epub ahead of print]
- Diagnosing metabolic acidosis in chronic kidney disease: importance of blood pH and serum anion gap
- Jun-Ya Kaimori, Yusuke Sakaguchi, Sachio Kajimoto, Yuta Asahina, Tatsufumi Oka, Koki Hattori, Yohei Doi, Yoshitaka Isaka
- Received September 7, 2021 Accepted October 18, 2021
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Metabolic acidosis is one of the most common complications of chronic kidney disease (CKD). It is associated with the progression of CKD, and many other functional impairments. Until recently, only serum bicarbonate levels have been used to evaluate acid-base changes in patients with reduced kidney function. However, recent emerging evidence suggests that nephrologists should reevaluate the clinical approach for diagnosing... -
DOI: https://doi.org/10.23876/j.krcp.21.200 [Epub ahead of print]
- Original Articles
- The importance of muscle mass in predicting intradialytic hypotension in patients undergoing maintenance hemodialysis
- Hyung Eun Son, Ji Young Ryu, Kyunghoon Lee, Young Il Choi, Myeong Sung Kim, Inwhee Park, Gyu Tae Shin, Heungsoo Kim, Curie Ahn, Sejoong Kim, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Soyeon Ahn, Seung Sik Hwang, Jong Cheol Jeong
- Received July 23, 2021 Accepted February 8, 2022
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Background: Patients undergoing hemodialysis are susceptible to sarcopenia. As intracellular reservoirs of water, skeletal muscles are important contributors to intradialytic hypotension. This study was designed to determine the role of skeletal muscle mass in intradialytic hypotension. Methods: In a cross-sectional study, the body composition of 177 patients was measured immediately after hemodialysis using bioelectrical impedance analysis. The parameters measured were... -
DOI: https://doi.org/10.23876/j.krcp.21.153 [Epub ahead of print]
- External validation of the International Prediction Tool in Korean patients with immunoglobulin A nephropathy
- Young Su Joo, Hyoung Woo Kim, Chung Hee Baek, Jung Tak Park, Hajeong Lee, Beom Jin Lim, Tae-Hyun Yoo, Kyung Chul Moon, Ho Jun Chin, Shin-Wook Kang, Seung Hyeok Han
- Received January 11, 2022 Accepted March 2, 2022
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Background: The International IgA Nephropathy Prediction Tool (IIgAN-PT) has been recently developed to estimate the progression risk of immunoglobulin A nephropathy (IgAN). This study aimed to evaluate the clinical performance of this prediction tool in a large IgAN cohort in Korea. Methods: The study cohort was comprised of 2,064 patients with biopsy-proven IgAN from four medical centers between March 2012 and... -
DOI: https://doi.org/10.23876/j.krcp.22.006 [Epub ahead of print]
- Albuminuria, estimated glomerular filtration rate, and traditional predictors for composite cardiovascular and kidney outcome: a population-based cohort study in Korea
- Hae Hyuk Jung
- Received January 11, 2022 Accepted March 12, 2022
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Background: Certain pharmacotherapies have shown to be effective for both cardiac and kidney outcomes. Although risk prediction is important in treatment decision-making, few studies have evaluated prediction models for composite cardiovascular and kidney outcomes. Methods: This study included 2,195,341 Korean adults from a nationwide cohort for chronic kidney disease and a representative sample of the general population, with a 9-year... -
DOI: https://doi.org/10.23876/j.krcp.22.005 [Epub ahead of print]
- Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs
- Hyuk Huh, Ejin Kim, Una Amelia Yoon, Mun Jeong Choi, Hyewon Lee, Soie Kwon, Clara Tammy Kim, Dong Ki Kim, Yon Su Kim, Chun Soo Lim, Jung Pyo Lee, Ho Kim, Yong Chul Kim
- Received October 7, 2021 Accepted February 14, 2022
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Background: Growing evidence suggests that environmental air pollution adversely affects kidney health. To date, the association between carbon monoxide (CO) and mortality in patients with end-stage renal disease (ESRD) has not been examined. Methods: Among 134,478 dialysis patients in the Korean ESRD cohort between 2001 and 2014, 8,130 deceased hemodialysis patients were enrolled, and data were analyzed using bidirectional, unidirectional, and... -
DOI: https://doi.org/10.23876/j.krcp.21.228 [Epub ahead of print]
- A multicenter, randomized, open-label, comparative, phase IV study to evaluate the efficacy and safety of combined treatment with mycophenolate mofetil and corticosteroids in advanced immunoglobulin A nephropathy
- Sang Youb Han, Chan-Young Jung, Sang Ho Lee, Dong Won Lee, Sik Lee, Chan-Duck Kim, Bum Soon Choi, Beom Seok Kim
- Received July 15, 2021 Accepted December 7, 2021
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Background: It remains unclear whether immunosuppressive agents are effective in patients with immunoglobulin A nephropathy (IgAN). We investigated the efficacy of a mycophenolate mofetil (MMF) and corticosteroid combination therapy in patients with advanced IgAN. Methods: We conducted a multicenter, randomized, placebo-controlled, parallel-group study of 48 weeks administration of MMF and corticosteroids in biopsy-proven advanced IgAN patients with estimated glomerular filtration... -
DOI: https://doi.org/10.23876/j.krcp.21.146 [Epub ahead of print]
- An intradialytic aerobic exercise program ameliorates frailty and improves dialysis adequacy and quality of life among hemodialysis patients: a randomized controlled trial
- Sunki Kim, Hye-Ja Park, Dong-Ho Yang
- Received November 27, 2021 Accepted February 7, 2022
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Background: Hemodialysis patients with chronic kidney disease exhibit impaired exercise tolerance and functional decline. Despite the life-saving benefits of adequate dialysis, those declines translate into frailty and deteriorating quality of life (QoL). This study evaluated the effects of an intradialytic aerobic exercise program on frailty, dialysis adequacy, and QoL among hemodialysis patients. Methods: Patients at an university hospital-affiliated hemodialysis center... -
DOI: https://doi.org/10.23876/j.krcp.21.284 [Epub ahead of print]
- Mayo imaging classification is a good predictor of rapid progress among Korean patients with autosomal dominant polycystic kidney disease: results from the KNOW-CKD study
- Hayne Cho Park, Yeji Hong, Jeong-Heum Yeon, Hyunjin Ryu, Yong-Chul Kim, Joongyub Lee, Yeong Hoon Kim, Dong-Wan Chae, WooKyung Chung, Curie Ahn, Kook-Hwan Oh, Yun Kyu Oh
- Received November 3, 2021 Accepted December 29, 2021
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Background: Mayo imaging classification (MIC) is a useful biomarker to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). This study was performed to validate MIC in the prediction of renal outcome in a prospective Korean ADPKD cohort and evaluate clinical parameters associated with rapid disease progression. Methods: A total of 178 ADPKD patients were enrolled and prospectively observed for... -
DOI: https://doi.org/10.23876/j.krcp.21.261 [Epub ahead of print]
- Humoral response to viral vector COVID-19 vaccine in hemodialysis patients
- Niranjan Raja, Arul Rajagopalan, Jegan Arunachalam, Arun Prasath, Rakesh Durai, Manorajan Rajendran
- Received August 19, 2021 Accepted October 31, 2021
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Background: The coronavirus disease 2019 (COVID-19) vaccine is not readily available in many countries where dosing interval is spaced more than ideal. Patients with chronic kidney disease, especially those on maintenance hemodialysis, have a tendency for a reduced immune response. This study was undertaken to demonstrate the distinct humoral immune response in patients with kidney failure receiving maintenance hemodialysis to... -
DOI: https://doi.org/10.23876/j.krcp.21.184 [Epub ahead of print]
- The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with end-stage kidney disease
- Da Won Kim, Munpyo Lee, Kwon Jae Lee, Yeon Hee Lee, Dongryul Kim, Seok Joon Shin, Hye Eun Yoon
- Received April 1, 2021 Accepted October 30, 2021
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Background: Little is known about how the interaction between red blood cell distribution width (RDW) and vascular calcification (VC) affects cardiovascular (CV) events and mortality in end-stage kidney disease (ESKD) patients. This study investigated the combined prognostic effect of RDW and VC in ESKD patients starting dialysis. Methods: A retrospective single-center study of 582 ESKD patients was conducted. VC was... -
DOI: https://doi.org/10.23876/j.krcp.21.078 [Epub ahead of print]
- Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality
- Jeong-Hoon Lim, Ga Young Lee, Yena Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Dong-Il Won, Chan-Duck Kim
- Received September 14, 2021 Accepted November 16, 2021
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Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided... -
DOI: https://doi.org/10.23876/j.krcp.21.207 [Epub ahead of print]
- Genetic variants of interferon lambda-related genes and chronic kidney disease susceptibility in the Korean population
- Jin Ho Kwak, Jin Hyuk Paek, Gyeong Im Yu, Seungyeup Han, Woo Yeong Park, Yaerim Kim, Dong Hoon Shin, Kyubok Jin
- Received March 30, 2021 Accepted December 22, 2021
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Background: Chronic kidney disease (CKD) is a common condition leading to renal dysfunction and is closely related to increased cardiovascular and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. This research examines the interrelationship between candidate genes polymorphisms of interferon lambda (IFNL) induction, its signaling pathway, and CKD. Methods:... -
DOI: https://doi.org/10.23876/j.krcp.21.075 [Epub ahead of print]
- Parathyroidectomy versus cinacalcet in the treatment of tertiary hyperparathyroidism after kidney transplantation: a retrospective study
- Suyun Jung, Hyosang Kim, Hyunwook Kwon, Sung Shin, Young Hoon Kim, Won Woong Kim, Tae-Yon Sung, Yu-Mi Lee, Ki-Wook Chung, Su-Kil Park, Chung Hee Baek
- Received September 13, 2021 Accepted December 10, 2021
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Background: Hyperparathyroidism is common in patients with chronic kidney disease with reduced renal function and has been observed after kidney transplantation. The optimal treatment for cases in which hyperparathyroidism persists after kidney transplantation has not been determined. Methods: This retrospective study included 83 patients with tertiary hyperparathyroidism who underwent kidney transplantation between 2000 and 2018 at a single tertiary center in... -
DOI: https://doi.org/10.23876/j.krcp.21.210 [Epub ahead of print]
- Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial
- Huijin Yang, Songuk Yoon, Eun Jung Kim, Jang Won Seo, Ja-Ryong Koo, Yun Kyu Oh, You Hwan Jo, Sejoong Kim, Seon Ha Baek
- Received August 14, 2021 Accepted November 21, 2021
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Background: Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection. Methods: We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age,... -
DOI: https://doi.org/10.23876/j.krcp.21.180 [Epub ahead of print]
- Recalibration and validation of the Charlson Comorbidity Index in acute kidney injury patients underwent continuous renal replacement therapy
- Jinwoo Lee, Jiyun Jung, Jangwook Lee, Jung Tak Park, Chan-Young Jung, Yong Chul Kim, Dong Ki Kim, Jung Pyo Lee, Sung Jun Shin, Jae Yoon Park
- Received May 14, 2021 Accepted September 14, 2021
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Background: Comorbid conditions impact the survival of patients with severe acute kidney injury (AKI) who require continuous renal replacement therapy (CRRT). The weights assigned to comorbidities in predicting survival vary based on type of index, disease, and advances in management of comorbidities. We developed a modified Charlson Comorbidity Index (CCI) for use in patients with AKI requiring CRRT (mCCI-CRRT) and... -
DOI: https://doi.org/10.23876/j.krcp.21.110 [Epub ahead of print]
- Estimating baseline creatinine values to define acute kidney injury in critically ill pediatric patients
- Yeon Joo Lee, Young Seo Park, Seong Jong Park, Won Kyoung Jhang
- Received May 29, 2021 Accepted September 10, 2021
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Background: Acute kidney injury (AKI) is a common complication in critically ill children. However, the common lack of baseline serum creatinine values affects AKI diagnosis and staging. Several approaches for estimating baseline creatinine values in those patients were evaluated. Methods: This single-center retrospective study enrolled pediatric patients with documented serum creatinine measurements within 3 months before admission and more than... -
DOI: https://doi.org/10.23876/j.krcp.21.120 [Epub ahead of print]
- Role of bicarbonate and volume therapy in the prevention of acute kidney injury in rhabdomyolysis: a retrospective propensity score-matched cohort study
- Hye Won Kim, Sejoong Kim, Jung Hun Ohn, Nak-Hyun Kim, Jongchan Lee, Eun Sun Kim, Yejee Lim, Jae Ho Cho, Hee Sun Park, Jiwon Ryu, Sun-wook Kim
- Received April 20, 2021 Accepted October 10, 2021
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Background: Although bicarbonate has traditionally been used to treat patients with rhabdomyolysis at high risk of acute kidney injury (AKI), it is unclear whether this is beneficial. This study compared bicarbonate therapy to non-bicarbonate therapy for the prevention of AKI and mortality in rhabdomyolysis patients. Methods: In a propensity score-matched cohort study, patients with a creatine kinase (CK) level of >1,000... -
DOI: https://doi.org/10.23876/j.krcp.21.093 [Epub ahead of print]
- Correspondence
- Successful ABO-incompatible kidney transplantation and SARS-Cov-2 specific immune monitoring in a patient recovered from coronavirus infection
- Su Yeon Hong, Hyunjoo Bae, Sun Cheol Park, Chul Woo Yang, Eun-Jee Oh, Byung Ha Chung
- Received February 12, 2022 Accepted February 26, 2022
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DOI: https://doi.org/10.23876/j.krcp.22.029 [Epub ahead of print]
