The Usefulness of NT-proBNP in Children with Chronic Kidney Disease

Korean Journal of Nephrology 2009;28(3):199-204.

Hyun Hee Hwang, M.D., Suk Jin Hong, M.D., Min Hyun Cho, M.D. and Cheol Woo Ko, M.D.

Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu , Korea

임상연구 : 만성 신질환을 가진 소아에서 NT-proBNP의 유용성에 관한 연구

황현희, 홍석진, 조민현, 고철우

경북대학교 의학전문대학원 소아과학교실

Abstract

Purpose:NT-proBNP (N-terminal pro-brain natriuretic peptide) is mainly secreted by cardiac myocytes of ventricle and can be used asdiagnosis and prognostic factor for heart failure. The aim of this study was evaluating the usefulness of NT-ProBNP in children with chronic kidney disease. Methods:A total of ninety –two children with chronic kidney disease (CKD) were analyzed. The serum level of NT-proBNP were compared to age, sex, serum creatinine (Cr), estimated glomerular filtration rate (eGFR), blood pressure (BP), and body mass index (BMI). And we also compared it to ejection fraction (EF), fractional shortening (FS), cardio-thoracic ratio (CTR), intact parathyroid hormone (iPTH), hemoglobin (Hb), and Ca×P product in 11 dialysis children. Results:Among 92 patients, 75 patients had a normal Cr, and 17 patients had increased Cr. Dialysis patients were 11. Serum level of NT-proBNP showed positive correlation of serum Cr, and negative correlation of eGFR. In dialysis patients, serum level of NT-pro BNP showed negative correlation of EF on echocardiography. And was no relation with CTR, iPTH, Hb, Ca×P product, and BMI. Conclusion:NT-proBNP is a useful marker for evaluating the cardiac function and determining the ultrafiltration in pediatric dialysis patients.

Key Words: Brain natriuretic peptide, Kidney disease, Children