Kidney Res Clin Pract > Epub ahead of print |
Funding
This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI21C0293), and by the Aging Project (No. 2017M3A9D8062955) funded by the Ministry of Science and ICT.
Parameter | Week |
Group |
p-value |
||||
---|---|---|---|---|---|---|---|
Control | APX-115 | STZ | STZ + APX-115 | Control vs. STZ | STZ vs. STZ + APX-115 | ||
Body weight (g) | 52 | 36.7 ± 0.6 | 35.5 ± 0.5 | 28.9 ± 0.9*** | 30.5 ± 0.8*** | <0.001 | 0.58 |
56 | 34.6 ± 0.8 | 35.3 ± 1.3 | 27.9 ± 0.8*** | 28.9 ± 0.5*** | <0.001 | 0.86 | |
60 | 34.2 ± 0.7 | 35.5 ± 1.3 | 27.3 ± 0.8*** | 29.2 ± 0.8*** | <0.001 | 0.72 | |
64 | 34.0 ± 0.7 | 35.5 ± 1.3 | 27.3 ± 0.8*** | 28.5 ± 0.6*** | <0.001 | 0.93 | |
Food intake (g/day) | 52 | 3.7 ± 0.1 | 3.7 ± 0.1 | 5.8 ± 0.2*** | 5.6 ± 0.1*** | <0.001 | 0.49 |
56 | 4.1 ± 0.1 | 4.2 ± 0.2 | 7.8 ± 0.3*** | 7.5 ± 0.3*** | <0.001 | 0.52 | |
60 | 3.7 ± 0.1 | 3.3 ± 0.2 | 6.2 ± 0.2*** | 8.2 ± 0.5***,# | <0.001 | 0.04 | |
64 | 4.4 ± 0.2 | 4.5 ± 0.1 | 6.0 ± 0.3*** | 5.8 ± 0.2*** | <0.001 | 0.64 | |
Water intake (mL/day) | 52 | 3.6 ± 0.1 | 4.4 ± 0.1 | 23.5 ± 1.1*** | 22.3 ± 0.8*** | <0.001 | 0.30 |
56 | 4.6 ± 0.3 | 5.4 ± 0.1 | 30.0 ± 2.6*** | 29.5 ± 2.2*** | <0.001 | 0.88 | |
60 | 5.7 ± 1.0 | 3.6 ± 0.2 | 26.7 ± 2.2*** | 27.9 ± 2.6*** | <0.001 | 0.68 | |
64 | 5.8 ± 0.8 | 5.6 ± 0.1 | 25.5 ± 2.0*** | 27.9 ± 2.2*** | <0.001 | 0.80 | |
Urinevolume (mL/day) | 52 | 2.4 ± 0.6 | 2.3 ± 0.2 | 14.9 ± 0.8*** | 12.6 ± 1.7*** | <0.001 | 0.14 |
56 | 1.8 ± 0.2 | 1.9 ± 0.4 | 11.7 ± 1.3*** | 9.2 ± 1.4*** | <0.001 | 0.14 | |
60 | 1.6 ± 0.3 | 2.2 ± 0.4 | 12.0 ± 1.0*** | 9.9 ± 1.3*** | <0.001 | 0.13 | |
64 | 1.9 ± 0.2 | 2.1 ± 0.4 | 16.6 ± 1.3*** | 13.1 ± 1.8*** | <0.001 | 0.06 | |
Fasting blood glucose (mg/dL) | 52 | 238 ± 19 | 218 ± 12 | 532 ± 54*** | 571 ± 35*** | <0.001 | 0.46 |
56 | 220 ± 10 | 160 ± 27 | 618 ± 30*** | 530 ± 40***,# | <0.001 | 0.04 | |
60 | 184 ± 8 | 149 ± 6 | 582 ± 31*** | 609 ± 52*** | <0.001 | 0.58 | |
64 | 207 ± 19 | 129 ± 28 | 710 ± 43*** | 689 ± 51*** | <0.001 | 0.70 | |
HbA1c (%) | 56 | 4.9 ± 0.1 | 4.0 ± 0.6 | 8.8 ± 0.4*** | 8.8 ± 0.6*** | <0.001 | 0.99 |
60 | 4.7 ± 0.2 | 4.4 ± 0.1 | 10.0 ± 0.5*** | 7.9 ± 0.3***,## | <0.001 | 0.001 | |
64 | 4.8 ± 0.1 | 4.6 ± 0.1 | 10.0 ± 0.5*** | 8.0 ± 0.2***,### | <0.001 | <0.001 | |
SBP (mmHg) | 64 | 106 ± 4 | 102 ± 2 | 98 ± 4 | 104 ± 2 | 0.58 | 0.31 |
Serum creatinine (mg/dL) | 64 | 0.56 ± 0.01 | 0.57 ± 0.01 | 0.62 ± 0.02 | 0.61 ± 0.02 | 0.47 | 0.28 |
Serum cystatin C (ng/mL) | 64 | 9,296 ± 550 | 7,767 ± 467 | 9,376 ± 518 | 7,410 ± 569# | 0.16 | 0.01 |
Jeong Hoon Park
https://orcid.org/0000-0001-6073-7782
Sung Gi Yoon
https://orcid.org/0000-0003-0272-9586
Jung Yeon Ghee
https://orcid.org/0000-0002-5817-237X
Ji Ae Yoo
https://orcid.org/0000-0003-1748-5641
Jin Joo Cha
https://orcid.org/0000-0001-6779-0113
Young Sun Kang
https://orcid.org/0000-0002-4061-386X
Sang Youb Han
https://orcid.org/0000-0003-3312-0597
Yun Jae Seol
https://orcid.org/0000-0002-2636-9004
Jee Young Han
https://orcid.org/0000-0003-3224-4029
Dae Ryong Cha
https://orcid.org/0000-0003-0063-2844
Pathology identifies glomerular treatment targets in diabetic nephropathy2018 ;37(2)