| Very-Late Onset Diffuse Large B-cell Lymphoma with CD3 Coexpression in a Kidney Transplant Patient |
| Biro Kim, M.D.1, Sungjin Chung, M.D.2, Seok-hui Kang, M.D.2, Seok Goo Cho, M.D.3, Cheol Whee Park, M.D.2 and Yoon Sik Chang, M.D.2 |
Division of Nephrology1
Department of Internal Medicine, Sanggye -Paik Hospital, The Inje University, Seoul, Korea Divisions of Nephrology2 and Hematology3
Department of Internal Medicine, College of Medicine, The Catholic University of Korea |
| 증례 : Very-Late Onset Diffuse Large B-cell Lymphoma with CD3 Coexpression in a Kidney Transplant Patient |
| Biro Kim, M.D.1, Sungjin Chung, M.D.2, Seok-hui Kang, M.D.2, Seok Goo Cho, M.D.3, Cheol Whee Park, M.D.2 and Yoon Sik Chang, M.D.2 |
| Division of Nephrology1, Department of Internal Medicine, Sanggye -Paik Hospital, The Inje University, Seoul, Korea Divisions of Nephrology2 and Hematology3, Department of Internal Medicine, College of Medicine, The Catholic University of Korea |
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| Abstract |
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B-lineage non-Hodgkin lymphoma may aberrantly coexpress T-cell markers. In general population, however, cases of diffuse large B-cell lymphomas with CD3 co-expression are rare because the CD3 marker is the most lineage specific T-cell antigen. We report a case of CD3 coexpressed diffuse large B-cell lymphoma in a 47-year-old male patient presented with dyspepsia who had transplanted a kidney 17 years ago. An esophagogastroduodenoscopy displayed an ulcerated mass in the gastric antrum. The pathology of the mass was monomorphic post-transplant lymphoproliferative disorder - specifically, CD20- and CD3- positive diffuse large B-cell lymphoma. Resection of the mass and postop chemotherapy were performed. A follow-up computerized tomography showed disapperance of tumor. No recurrence was observed until 7 month after treatment. Nevertheless, the patient’s renal function gradually aggrevated and progressed to end stage renal disease. As far as we know, this is the first case of diffuse large B-cell lymphoma with CD3 coexpression after kidney transplant. |
| Key Words:
Neoplasm transplantation, Lymphoproliferative disorder, Diffuse large B-cell lymphoma |
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