| Risk Factors for New Onset Diabetes after Transplantation among Renal Transplant Recipients Treated with Tacrolimus |
| Yu Kyong Choi, M.D.1, Ye-Jee Kim, MSc.2, Nam-Kyong Choi, Ph.D.2, 3, Min Young Kim, M.D.1, Na Na Baek, M.D.1, Ji Youn Youm, M.D.1, Jung Eun Lee, M.D.1, Dae Joong Kim, M.D.1, Yoon-Goo Kim, M.D.1, Ha Young Oh, M.D.1 and Wooseong Huh, M.D.1 |
Sungkyunkwan University College of Medicine, Division of Nephrology1
Samsung Medical Center Department of Preventive Medicine2
Seoul National University College of Medicine, Medical Research Center, Seoul National University Department of Preventive Medicine, Seoul National University College of Medicine3 |
| 원저 : Tacrolimus를 근간으로 한 면역억제제를 복용하는 신장이식 환자에서 이식 후 새로 발생한 당뇨병의 위험인자 |
| 최유경1, 김예지2, 최남경2, 3, 김민영1, 백나나1, 염지연1, 이정은1, 김대중1, 김윤구1, 오하영1, 허우성1 |
| 성균관대학교 의과대학 내과학교실 삼성서울병원 신장내과1, 서울대학교 의과대학 예방의학교실2, 서울대학교 의학연구원3 |
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| Abstract |
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Purpose: This study was conducted to identify risk factors for new onset diabetes after transplantation (NODAT) among renal transplant recipients treated with tacrolimus-based immunosuppressant.
Methods: We selected renal transplant recipients who underwent surgery at Samsung Seoul Hospital between May 2001 and July 2009. Exclusion criteria were as follows: recipients <18 years old, history of diabetes mellitus (DM) or impaired glucose tolerance. Analysis of possible risk factors for NODAT included age, gender, body mass index, co-morbid diseases, family history of DM, infection of hepatitis B or polyomavirus, type of donors (cadaver or living) and acute rejection. Overall incidence and median value of NODAT onset day were analyzed with Kaplan-Meier curve. We calculated crude incidence rate and relative risk (RR) and 95% confidence interval (CI) for independent risk factors of NODAT using Cox proportional hazard analysis.
Results: A total of 278 patients were included and the incidence of NODAT was 13.3% (5.6/100 person-year) and the median duration of NODAT onset was 28 days. In Cox analysis, risk factors for NODAT were age (45-59 years: RR=1.41, 95% CI 1.09-1.83, 60> years: RR=4.36, 95% CI 2.00-9.49), family history of DM (RR=1.62, 95% CI 1.12-2.34) and polyomavirus infection (RR=1.40, 95% CI 1.08-1.81).
Conclusion: The risk factors for NODAT among renal transplant recipients treated with tacrolimusbased regimen were age (>45 years old), family history of DM and polyomavirus infection. |
| Key Words:
Kidney transplantation, Diabetes mellitus, Tacrolimus |
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