A Case of Successful Hemoperfusion in the Treatment of Acute Severe Clozapine Intoxication

Korean Journal of Nephrology 2009;28(6):639-642.

Hwa Jong Kim, M.D., Su Ji Kim, M.D., Kwan Hyun Lee, M.D., Hyo Wook Gil, M.D., Jong Oh Yang, M.D., Eun Young Lee, M.D. and Sae Yong Hong, M.D.

Division of Nephrology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea

증례 : 혈액관류요법에 의하여 성공적으로 치료한 중증 clozapine 중독 1예

김화종, 김수지, 이관현, 길효욱, 양종오, 이은영, 홍세용

순천향대학교 천안병원 신장내과

Abstract

Clozapine, a psychotropic drug commonly used in the treatment of schizophrenia or schizophrenic affective disorders may show side effects such as agranulocytosis, cardiomyositis, cognitive and motor depression in therapeutic doses and central nervous system depression, respiratory depression, arrhythmia, seizures, and even death in case of severe intoxication, warranting an aggressive treatment. We hereby report a case of clozapine overdose patient who ingested a potentially fatal dose of 3 grams and showed stuporous mental state, who was treated successfully by hemoperfusion without any sequelae.

Key Words: Clozapine, Hemoperfusion