| Changes of Bone Mineral Densities in Children with Idiopathic Hypercalciuria |
| Eun Hui Hong, M.D.1, Jung Ok Kim, M.D.1 , Mi Ae Chu, M.D.1, Jun Young Kim, M.D.1 Hwan Seok Lee, M.D.1, Min Hyun Cho, M.D.1, Cheol Woo Ko, M.D., Ph.D.1 Dong Gyu Jo, M.D., Ph.D.2 and Jae Tae Lee, M.D., Ph.D.3 |
Department of Pediatrics1
Internal Medicine2
Nuclear Medicine3 Kyungpook National University, School of Medicine, Daegu, Korea |
| 원저 : 소아 특발성 고칼슘뇨증에서 골밀도의 변화 |
| 홍은희1 김정옥1 추미애1 김준영1 이환석1 조민현1 고철우1 조동규2 이재태3 |
| 경북대학교 의과대학 소아과학교실1, 내과학교실2, 핵의학교실3 |
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| Abstract |
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Purpose : Idiopathic hypercalciuria is a common clinical disorder in children with hematuria or nephrolithiasis.
Recently, it has been reported that idiopathic hypercalciuria may disturb the metabolism of bone and induce its loss. We measured the biochemical markers of bone metabolism and bone mineral densities (BMD) by dual energy X-ray absorptiometry (DEXA) in children with idiopathic hypercalciuria to elucidate the prevalence and clinical significance of osteopenia.
Methods : From 1997 to 2005, 52 children with idiopathic hypercalciuria were included in this study.
The biochemical markers of bone metabolism were measured in all 52 patients. BMD was measured in 21 patients initially and additional 6 patients during the follow-up.
Results : Mean age of patients was 6 years 7 months, and the male to female ratio was 1.26:1. BMD Z-scores were less than -1 in 10 of initial 21 patients (osteopenia), and -2.5 in 2 of 10 osteopenic patients (osteoporosis). There was a negative correlation between BMD Z-score and the level of osteocalcin. However, there were no significant differences in BMD Z-scores and other biochemical markers of bone metabolism among groups divided by sex, the type of idiopathic hypercalciuria, and the
presence of urinary stone.
Conclusion : Idiopathic hypercalciuria can be not only the cause of hematuria, but also of osteopenia in children. We suggest that the measurement of BMD in children with idiopathic hypercalciuria should be performed routinely with regular follow-up.
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| Key Words:
Hypercalciuria, Bone mineral density, Children |
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