|
| Chinese Herbs Nephropathy 1예 (A Case of Chinese Herbs Nephropathy) |
| 남기덕(Gee Duk Nam),이태원(Tae Won Lee),노정현(Jung Hyun Rho),양문호(Moon Ho Yang),조병수(Byung Soo Jo),홍성표(Sung Pyo Hong),임천규(Chun Gyu Lim),김명재(Myung Jae Kim) |
|
|
| Abstract |
|
A new type of rapidly progressive interstitial fibrosis of the kidney, the so-called Chinese Herbs Nephropathy(CHN), has been recently reported in two European women who had followed the same slimming regimen including Chinese herbs. Several characteristics of this nephropathy have been high lighted: development of end-stage renal disease (ESRD) within 1-2 years, histology showing a striking extensive interstitial fibrosis, low-molecular-weight proteinuria, glycosuria without hyperglycemia, anemia and high risk of urothelial atypia and malignancy. Phytochemical analysis of slimming regimen including chinese herbs resulted in the identification in most of the herbs of aristolochic acids, known for their powerful nephrot-oxic properties. This disease has not been reported in Korea yet. The authors had experienced one case of CHN diagnosed by clinical, laboratory feature and renal biopsy. The patient, 30-year-old woman, had followed a chinese herbs regimen for lactation after delivery and few days later she sought medical advice because of anorexia, fatigue and generalized weakness. On laboratory examination, findings of renal failure, proteinuria, glycosuria and anemia was seen. Histological examination of a renal biopsy specimen showed focal interstitial fibrosis and atrophic tubules with mild mesangial proliferation. We emphasize the need of attention with the first report of CHN. |
|
PDF Links
Download Citation
