Korean Journal of Nephrology 1997;16(3):443-448.

미세변화 신증후군 환아에서 혈중 세포면역지표와 가용성 인터루킨 - 2 수용체의 변화

고철우 , 최병호 , 구자훈

Abstract

This study was conducted to see the role of cellular immune function in the pathogenesis of minimal change nephrotic syndrome. Study patients consisted of 19 children with biopsy-proven minimal change nephrotic syndrome, aged 2-15 yr. Controls were 10 age-matched healthy children. The pro- portion of T4 and Ts in peripheral blood were mea- sured with flocytometer using monoclonal antibodies during relapse and 1 month after remission. Serum soluble interleukin-2 receptor(sIL-2 R) was measured using ELIZA kit in both periods. The following results were obtained: (1) No significant change of serum sIL-2 R was noted between relapse and remission period. Both values of serum sIL-2 R did not show any significant change compared to the control value. (2) The proportion of Ts peripheral blood during relapse significantly increased compared to those of controls or remission period(p<0.01). (3) Increased proportion of Ts during relapse was not related to the history of taking immuno- suppressive agent such as cyclophosphamide re- cently, and not correlated with values of serum albumin or cholesterol during relapse. Conclusively, it can be said that increased pro- portion of Ts in peripheral blood may play an impor- tant role in the pathogenesis of minimal change nephrotic syndrome, and this increment of Ts seems not to be the secondary change caused by cytotoxic therapy or nephrotic syndrome itself.