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| 영양실조 상태인 지속성 외래복막투석 환자에서 단백동화호르몬이 체조성 및 단백질 대사에 미치는 영향 |
| 이승우 , 권건호 , 김경아 , 신현주 , 배성권 , 송기산 , 김문재 , 오민화 , 김진주 |
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| Abstract |
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To evaluate the effect of anabolic steroid(AS) on body composition and protein metabolism in malnouished CAPD patients, 7 CAPD patients who were proved to be malnourished by subjective global assessment received 200mg of AS, nandrolone decanoate, by intramuscular route monthly for 5 months. We analyzed tbe body composition, biochemical nutritional markers, plasma and dialysate amino acids(AA) before and after administration of AS. The mean age was 53.6±11.5 years, the sex ratio was 2:5, and the duration of CAPD was 28.5±18.7 months. Two patients were diabetics. Five months after AS administration, % lean body mass seemed to increase from 52.6±11.7 to 57.3±11,0%(P>0.05), but there were no significant changes in body weight and body mass index. Serum insulinlike growth factor-I (172.4±88.5 vs. 204.1±85.8ng/ml, P<0.05) and trans- ferrin(213.6±55.4 vs. 239.0±55.3mg/dl, P<0.05) were significantly increased, and serum total CO,,(31.1±4.5 vs. 25.9±2.5mM/L, P<0.05) were significantly decrea- sed. Urea nitrogen appearance(4.0±2,0 vs. 3.6±1.6g/ day) seemed to be decreased. Both plasma essential AA(EAA) level(738.3±206.5 vs. 492.5±187.2mmol/L, P<0.05) and peritoneal EAA loss(565.0 ± 186.1 vs. 377.4 ± 113.9 m mol/day, P<0.05) decreased significantly after administration. Plasma total and non- essential amino acids(NEAA) level tended to be inc- reased and peritoneal total and NEAA loss seemed to be decreased without statistical significance. In conclusion, AS seems to have anabolic effect and be useful in the correction of malnutrition in CAPD patients. |
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