Korean Journal of Nephrology 1997;16(4):688-694.

투석요법이 갑상선 기능 변화에 미치는 영향

김승긱, 김응석 , 김용섭 , 이정호 , 신영태

Abstract

The changes of thyroid hormones are expected in patients with chronic renal failure(CRF) because the kidney plays an important role in metabolism and excretion of thyroid hormones. In spite of many studies about this issue, there have not been full consensus about the nature and mechanism of thyroid hormone changes. We undertook the present study to reveal the dialysis effects on these hormones. We measured basal levels of serum total Tz (Tz), total Tq(Tq), free Tq4(FTq), reverse Tz(rTz) and TSH, and then calculated the ratio of Tz/Tq, rTz/Tz and rTz/Tq. The following groups were identifed: Group I -10 cases of normal controls, Group II-18 cases of pre-dialysis or treated conservatively, Group III-20 cases treated by maintenance hemodialysis(HD), Group 1V-18 cases treated by continuous ambulatory peritoneal dialysis(CAPD). Patients from group II, III and IV revealed significantly decreased levels of Tz and Tq, and increased ratio of rTzTq in comparison to the control group(P<0.05). Especially, CAPD group revealed significantly increased levels of T and FT in comparison to HD group(P<0.05). In the long-term dialysis group(>36months), the mean concentrations of free T levels revealed signi- fcantly decreased in comparison to the short-term dialysis group(P<0.05). Thyroid dysfunction with partial recovery cially, CAPD achieves dysfunction compared would be necessary. Are observed in CRF patients after dialysis therapy. Espesignificantly improved thyroid to HD, but further study would be necessary.