Korean Journal of Nephrology 1996;15(3):339-344.

대장균에 의한 요로감염환아에서 요중 칼슘배설의 증가

김소영 , 고철우

Abstract

A prospective study was conducted to evaluate the relationship between urinary tract infection by E. coli, non-urease producing microorganism and for- mation of urinary calcium stone in children. Study patients composed of 22 children (1 month- 5.3 years old) with UTIs who were admitted to the department of Pediatrics, Kyungpook National University Hospital from April to October 1995, and control group consisted of 14 children with minor illness. Spot urine Ca/Cr ratio were measured before and 1 week after treatment with appropriate anti- biotics, and 24 hour urine was collected in some study patients and controls for 24 hour urinary cal- cium excretion. And following results were obtained; In UTI group, spot urine Ca/Cr ratio (mg/mg) before treatment, 0.33±0.25, was significantly higher than values of 1 week after treatment and controls, 0.13±0,12, 0.13±0.06 respectively (p<0.05). The spot urine calcium proportion (ca/(ca+cr), mg/mg) before treatment in UTI group was 0.23±0.13, which was significantly higher compared to those of after treatment, 0.10+0.08 and controls, 0.11±0.05(p<0.05), and the spot urine creatinine proportion (cr/(ca+cr), mg/mg) before treatment in UTI group was 0.78± 0.13, which was significantly lower than those of 1 week after treatment, 0.900.08, and controls, 0.89± 0.13 (p<0.05). In summary, UTI by E. coli, non-urea splitting microorganism has been associated with increased urinary calcium and decreased urinary creatinine excretion. This may be due to impared tubular cal- cium reabsorption, and this may lead to the for- mation of calcium containing urinary stones.