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| 당뇨병성 신병증환자의 혈청 지질농도 |
| 김권기 , 황이숙 , 안재형 , 이태원 , 임천규 , 김명재 , 박원도 |
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| Abstract |
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Hyperlipidemia in diabetic nephropathy is a major risk factor of the cardiovascular complication. And so, we measured the serum lipid, lipoprotein and apoprotein concentrations in 63 diabetic patients with or without nephropathy to evaluate the influence of hyperglycemia, proteinuria and azotema on the serum concentrations of lipid, lipoprotein and apoprotein in diabetic ne- phropathy. The results were as follows; 1) The serum concentrations of cholesterol, triglycer- ide, total lipid, VLDL-Cholesterol, LDL-Cholesterol, pre B-lipoprotein and B-lipoprotein were significantly higher in diabetics than those in normal controls. 2) The serum concentrations of cholesterol and B- lipoprotein were significantly higher in diabetics with overt nephropathy than those without overt nephropa- thy. 3) The serum concentrations of cholesterol, VLDL- Cholesterol and pre Bp-lipoprotein were significantly higher in diabetics with renal insufficiency than those with normal renal function. 4) The serum concentrations of cholesterol, LDL- Cholesterol, total lipid, apoprotein B and B-lipoprotein were significantly higher and that apoprotein AI was significantly lower in diabetics with severe proteinuria (>3 g/day) than those with mild to moderate proteinur- ia (<3 g/day). These data suggest that the hyperglycemia, proteinur- ia, and azotemia may influence the hyperlipidemia and hyperlipoproteinemia in diabetic nephropathy. |
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