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| 신증후군 환아에서의 혈청 25 - Hydroxyvitamin D의 변화 |
| 이승재 , 김기홍 , 고철우 , 구자훈 |
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| Abstract |
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Prospective study was conducted to evaluate changes of serum calcium and vitamin D in children with ne- phrotie syndrome and normal renal function. Study patients consisted of 23 nephrotic children admitted at Kyungpook University Hospital from January to December 1990. Control group consisted of 10 healthy children aged 4 to 14 year. The following results were obtained. During relapse peroid of nephrotic syndrome, serum level of total calcium was 7.9±20.8mg/dl, and this value was significantly lower than control value of 9. 5±20.5, rose to 8.5±0.7 on the early remission day, and 9.2±0.8 mg/dl, on 1 month after remission. Blood level of ionized calcium was 3.4 k0.4mg/dl during relapse, and this value was also significantly lower than control value of 4.1±0.4, rose to 4.1±0.6mg/dl on lmonth after remission. Serum level of 25-Hydroxyvitamin D (25-HCC) was 4.2±2.9ng/ml during relapse, and this value was significantly lower than that of control, rose to 8.4 k10.8 on the early remission day, and 11.8 ±5.3 ng/ml on 1 month after remission. There was inverse correlation (r= -0.43, p<0.05) between levels of 25 -HCC and 25-hour urinary protein excretion and direct correlation with serum albumin (r=0.80, p<0.001). Blood level of parathyriod hormone showed no significant change. In coclusion. It can be said that Hypocalcemia in children with nephrotic syndrome is caused not only by lowered serum albumin but also by serum 25-HCC. |
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