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| Rifampin에 의한 급성신부전 1예 |
| 홍관수 , 이일중 , 김동욱 , 김영균 , 윤영석 , 방병기 |
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| Abstract |
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Acute renal failrue due to rifampin is relatively un- common side-effect. Recently the authors experienced a cases of rifampin induced acute renal failrue in a 48- year-old female patient. She was diagnosed as pulmo- nary tuberculosis 2 years ago. Since then she selfme- dicated various anti-tuberculous drugs. On history-tak- ing it was evident that she took rifampin intermittently. About 4 months before the present episode there was a history of self-limited oliguria history after rifampin administration. During that time she was hospitalized at a local hospital and anti-tuberculous medication was discontinued for 4 months. Again she took a single dose of rifampin (450mg) and fever, chill, itching, nausea, vomiting, abdominal pain and reddish mucoid stool developed. Oliguria also occurred and abdominal pain became severe. She was referred to Yeungnam Univer- sity Medical Center and was treated with 8 times of hemodialysis. Oliguric phases lasted about 11 days and she recovered slowly but without any sequelae. On 9th hospital day we prescribed isoniazid, ethambutol and cycloserine and no side-effect was noted. There was no evidence of hemolysis and we presume a hypersen- sitivity reaction was operating in this case. The authors report a case of rifampin-induced acute renal failure with review of literature. |
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