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| 소아 신증후군 환아에서 Cyclosporin - A 의치료경험 |
| 이하영 , 이명연 , 조병수 , 안창일 |
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| Abstract |
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In 4 children with steroid-dependent frequently relaps- ing (2) and steroid-resistant (2) minimal change ne- phrotic syndrome a trial of cyclosporin A treatment was justified. Cyclosporin A was administered for 8 weeks in combination with alternate prednisone. Cyclosporin A was started at an daily oral dose of 6 mg/day. Doses were adjusted to maintain plasma levels between 50 and 150 ng/ml. The results are as follow: Remission was achieved in 2/2 steroid-dependent frequently relapsing and 1/2 steroid-resistant minimal change nephrotic syndrome patients and reduction of proteinuria was achieved in 1/ 2 steroid-resistant patient. Side effects were observed: hypertrichosis (4 pts), skin black-discoloration (4 pts), gastrointestinal intolerance (2 pts), hypertension (2 pts). Renal toxicity of cyclosporin A was not observed. Our experience shows that 1) cyclosporin A can be used to induce a remission in frequently relapsing steroid-dependent and steroid resistant minimal change nephrotic syndrome and 2) low dose short term cyclosporin therapy does not produce nephrotoxicity. |
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