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| 태아 (胎兒) 의현사구체경화증 (賢絲球體硬化症) |
| 신희영 |
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| Abstract |
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Since Herxheimer (1909) first described the presence of glomerulosclerosis in the kidney of newborn, there had been only a few reports on the glomerulosclerosis seen among fetuses and neonates. We are still not aware of the true incidence of glomerulosclerosis in fetuses, particularly among different age groups of the fetuses. The authors conducted a study to elucidate the fre- quency and possible cause of this condition. A total of 307 normal fetal kidneys were selected from autopsy specimens ranging in gestational age from 15 to 41 weeks. A large section covering entire midlon- gitudinal surface of each kidney was made for the microscopic examination. The glomerulosclerosis was not seen in fetuses before the gestational age of 26 weeks. It was first seen in fetuses in the age range of 26-27 weeks and then tended to increase steadily with the aging of the fetus, approa- ching near 50% by term. The sclerotic glomerui located mostly in the juxtamedullary portion of the cortex and was generally larger than the remaining uninvolved ones. The sclerotic glomeruli were characterized by thickening of the parietal layer of the Bowmans capsule and were associated with segmental and global sclerosis of the glomerular capillary tufts. Periglomerular lamel- lated fibrosis was also commonly seen among these glomeruli. |
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