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| 심방추출액이 SHR계 백서의 신장기능에 미치는 영향 |
| 김용현 , 김탁희 , 조경우 |
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| Abstract |
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The heart has been suggested as an endocrine gland secreting a new hormone affecting renal functions. Atrial cardiocytes are confirmed to secrete peptides possessing a rapid and potent natiriuretic and diuretic activity. In the present experiment, it was attempted to explore the possible alteration of the renal responsive- ness to the atrial extract in spontaneously hypertensive rats as well as in normotensive Sprague-Dawley and Wistar rats as control. Intrarenal arterial infusion of atrial extract caused a decrease in blood pressure of spontaneously hyperten- sive rat as well as normotensive control rats. Plasma renin activity showed a decrease without significance in both spontaneously hypertensive and normotensive rats. Intrarenal arterial infusion of atrial extract caused increases of urinary volume and sodium excretion in normotensive rats, but did not affect in spontaneously hypertenssive rat. These date suggest that the natriuretic and diuretic effects by atrial extract are suppressed in spontaneously hypertensive rat compared to normotensive rats, and so that the renal responsiveness to the atrial natriuretic peptide may be altered in spontaneousely hypertensive rats. |
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