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| 소아에서의 각종 신질환과 B형간염 바이러스감염과의 관계 |
| 김연옥 , 구순모 , 이상범 , 구자훈 , 김용진 |
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| Abstract |
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A clinical study was conducted on 273 children with various renal diseases, who had been admi- tted to the pediatric ward of KNU hospital from November 1980 to February 1984. Incidence of HBsAg positivity was 9. 5 in the renal groups compared to 5, Q .g in the controls, and among th various renal diseases, primary glomerulonephritides causing nephrotic syndrome showed the highest rate of 20.4%.(ll out of 54 cases; p<0. 01). Among the biopsy-proven primarv glomerulonephritides, the highest rate of HBsAg positivity was seen in MGN with 50.0,.(4 out of 8 cases; p<0.05). HBeAg positivity in patients with HBs antigenemia also showed the highest rate in MGN groups, occuring in 3 out of 4 cases.Tissue staining of HBsAg utilizing PAP method (Dako Co. USA) on the biopsy-specimens of renal tissue from 13 children with HBs antigenemia(11 cases with primary nephrotic syndrome, 2 with HSP nephritis) showed negative staining in all of the specimens. In summary, our data would suggest that there is a strong correlation between hepatitis B viral infection and the primary glomerulonephritides, especially membranous nephropathy. Futhermore, it would indicate that HBeAg might play more prominent role than HBsAg in the pathogenesis of membranous nephropathy. |
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