Clinical Characteristics of Acute Myocardial Infarction in Dialysis Patients

Korean Journal of Nephrology 2009;28(1):41-43.

Seung Kyu Chung, M.D., Jin Seok Jeon, M.D., Tae Hyong Kim, M.D., Chul Kim, M.D., Soon Hyo Kwon, M.D., Hyun Jin Noh, M.D. and Dong Chul Han, M.D.

Department of Internal Medicine, College of Medicine Soon Chun Hyang University, Seoul, Korea

증례 : 장기간 Linezolid 치료 후 발생한 유산증 1예

정승규, 전진석, 김태형, 김 철, 권순효, 노현진, 한동철

순천향대학교 의과대학 내과학교실

Abstract

Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. Although impaired tissue oxygenation is usually responsible for the rise in lactate production, lactic acidosis could be caused by drugs including metformin and the nucleoside reverse-transcriptase inhibitors. Linezolid, an oxazolidinone antibiotic, is currently indicated to treat serious infections caused by vancomycin-resistant enterococcus and other gram-positive organisms. A 74-year old woman was found to have pyogenic vertebral osteomyelitis and treated with linezolid. Thirty-one days after linezolid therapy, she developed severe lactic acidosis. We report a case of lactic acidosis associated with prolonged linezolid therapy.

Key Words: Linezolid, Lactic acidosis