Kidney Res Clin Pract > Epub ahead of print |
Funding
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI22C1529), and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (RS-2023-00209312), and also supported by the Alumni of The Catholic University of Korea Division of Nephrology grant (2023RADN020901)
Data sharing statement
The data presented in this study are available from the corresponding author upon reasonable request.
Authors’ contributions
Conceptualization, Formal analysis: SC, BHC
Data curation: SC, HL, CWY
Funding acquisition: SC, HL, BHC
Investigation: SC, SHE, JWM
Methodology: SC, HEY
Writing–original draft: SC, HL, BHC
Writing–review & editing: All authors
All authors read and approved the final manuscript.
Characteristic |
Standard-risk group |
High-risk group |
||||
---|---|---|---|---|---|---|
W2H (n = 291) | H2W (n = 75) | p-value | W2H (n = 34) | H2W (n = 55) | p-value | |
Recipient age (yr) | 52.2 ± 8.4 | 47.5 ± 8.5 | <0.001* | 53.0 ± 8.4 | 48.9 ± 7.6 | 0.02* |
Donor age (yr) | 49.7 ± 8.1 | 49.6 ± 9.0 | 0.96 | 50.4 ± 8.3 | 51.8 ± 7.9 | 0.41 |
Cause of ESKD | 0.10 | 0.08 | ||||
DM | 103 (35.4) | 19 (25.3) | 14 (41.2) | 13 (23.6) | ||
Non-DM | 188 (64.6) | 56 (74.7) | 20 (58.8) | 42 (76.4) | ||
Pre-KT RRT | 0.73 | 0.19 | ||||
HD/PD/preemptive | 162 (55.7)/30 (10.3)/ | 43 (57.3)/5 (6.7)/ | 24 (70.6)/2 (5.9)/ | 28 (50.9)/6 (10.9)/ | ||
99 (34.0) | 27 (36.3) | 8 (23.5) | 21 (38.2) | |||
HLA mismatch number | 4.6 ± 1.1 | 4.6 ± 1.1 | 0.76 | 4.4 ± 0.9 | 4.8 ± 0.9 | 0.10 |
Crossmatch test positivity | ||||||
T-cell CDC-XM | 2 (0.7) | 1 (1.3) | 0.58 | 0 (0) | 4 (7.3) | 0.11 |
B-cell CDC-XM | 3 (1.0) | 1 (1.3) | 0.82 | 2 (5.9) | 4 (7.3) | 0.80 |
T-cell FCXM | 4 (1.4) | 1 (1.3) | 0.88 | 2 (5.9) | 12 (21.8) | 0.09 |
B-cell FCXM | 11 (3.8) | 4 (5.3) | 0.74 | 4 (11.8) | 23(41.8) | <0.001** |
HLA-DSA class I MFI value | 227 | 52 | 0.07 | 29 | 44 | 0.08 |
<1,000 | 225 (99.1) | 48 (92.3) | 24 (82.8) | 24 (54.5) | ||
1,000–3,000 | 1 (0.4) | 4 (7.7) | 2 (6.9) | 2 (4.5) | ||
3,000–5,000 | 1 (0.4) | 0 (0) | 1 (3.4) | 9 (20.5) | ||
5,000–10,000 | 0 (0) | 0 (0) | 2 (6.9) | 7 (15.9) | ||
>10,000 | 0 (0) | 0 (0) | 0 (0) | 2 (4.5) | ||
HLA-DSA class II MFI value | 226 | 52 | 0.45 | 29 | 44 | 0.53 |
<1,000 | 219 (96.9) | 49 (94.2) | 22 (75.9) | 25 (56.8) | ||
1,000–3,000 | 5 (2.2) | 1 (1.9) | 4 (13.8) | 9 (20.5) | ||
3,000–5,000 | 1 (0.4) | 1 (1.9) | 1 (3.4) | 3 (6.8) | ||
5,000–10,000 | 1 (0.4) | 1 (1.9) | 1 (3.4) | 5 (11.4) | ||
>10,000 | 0 (0) | 0 (0) | 1 (3.4) | 2 (4.5) | ||
Induction | 243 | 60 | 0.43 | 32 | 48 | 0.54 |
ATG | 31 (12.8) | 10 (16.7) | 24 (75.0) | 33 (68.8) | ||
Basiliximab | 212 (87.2) | 50 (83.3) | 8 (25.0) | 15 (34.1) | ||
ABO incompatible | 106 (36.4) | 31 (41.3) | 0.43 | 14 (41.2) | 23 (41.8) | 0.95 |
Data are expressed as mean ± standard deviation, number (%), or number only.
ATG, antithymocyte globulin; CDC, complement dependent cytotoxicity; DM, diabetes mellitus; DSA, donor-specific antibody; ESKD, end-stage kidney disease; FCXM, flow cytometry crossmatch; HD, hemodialysis; H2W, husband-to-wife recipient; HLA, human leukocyte antigen; KT, kidney transplantation; MFI, median fluorescent intensity; PD, peritoneal dialysis; RRT, renal replacement therapy; W2H, wife-to-husband recipient; XM, crossmatch.
Predictor |
Unadjusted model |
Adjusted model |
||
---|---|---|---|---|
HR (95% CI) | p-value | HR (95% CI) | p-value | |
High risk, H2W | 2.33 (1.12–4.86) | 0.02* | 2.35 (1.11–4.98) | 0.03* |
Cause of ESKD | 0.89 (0.45–1.74) | 0.73 | 0.92 (0.46–1.84) | 0.82 |
Recipient age | 1.00 (0.97–1.04) | 0.95 | 1.01 (0.97–1.05) | 0.80 |
Data are expressed as number (%).
BKV, BK polyomavirus; CMV, cytomegalovirus; H2W, husband-to-wife recipient; SDKT, spousal donor kidney transplantation; SSTI, skin and soft tissue infection; TB, tuberculosis; UTI, urinary tract infection; W2H, wife-to-husband recipient.
The p-values were analyzed by chi-square test.
Seunghyeok Choi
https://orcid.org/0009-0003-9213-0514
Hanbi Lee
https://orcid.org/0000-0001-7326-0602
Sang Hun Eum
https://orcid.org/0000-0002-5533-0459
Ji-Won Min
https://orcid.org/0000-0001-6295-8095
Hye Eun Yoon
https://orcid.org/0000-0002-6347-7282
Chul Woo Yang
https://orcid.org/0000-0001-9796-636X
Byung Ha Chung
https://orcid.org/0000-0003-0048-5717
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