| A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis |
| Eun Hye Kim, M.D., Bun Kim, M.D., Su Jin Lee, M.D., Min Hyung Kim, M.D., Shin Wook Kang, M.D., Kyu Hyun Chio, M.D. and Tae Hyun Yoo, M.D. |
| Department of Internal Medicine, College of Medicine, Yonsei University, seoul, Korea |
| 증례 : 복막투석 환자에서 발생한 Baclofen 뇌증 1예 |
| 김은혜, 김 번, 이수진, 김민형, 강신욱, 최규헌, 유태현 |
| 연세대학교 의과대학 내과학교실 |
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| Abstract |
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Baclofen (β-4-chlorophenyl-γ-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity. |
| Key Words:
Baclofen, Encephalopathy, Continuous ambulatory peritoneal dialysis |
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