Korean Journal of Nephrology 2011;30(2):211-214.
A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis
Eun Hye Kim, M.D., Bun Kim, M.D., Su Jin Lee, M.D., Min Hyung Kim, M.D., Shin Wook Kang, M.D., Kyu Hyun Chio, M.D. and Tae Hyun Yoo, M.D.
Department of Internal Medicine, College of Medicine, Yonsei University, seoul, Korea
증례 : 복막투석 환자에서 발생한 Baclofen 뇌증 1예
김은혜, 김 번, 이수진, 김민형, 강신욱, 최규헌, 유태현
연세대학교 의과대학 내과학교실
Abstract
Baclofen (β-4-chlorophenyl-γ-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity.
Key Words: Baclofen, Encephalopathy, Continuous ambulatory peritoneal dialysis


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