Concurrence of Fibrillary Glomerulonephritis and AL Amyloidosis Associated with Monoclonal Gammopathy

Korean Journal of Nephrology 2011;30(2):187-190.

Dong Suk Chang, M.D.1, Won Ik Jang, M.D.1, Dae Eun Choi, M.D.1, Ki Ryang Na, M.D.1, Kwang Sun Suh, M.D.2, Yong Tai Shin, M.D.1 and Kang Wook Lee, M.D.1

Department of Internal Medicine¹
and Department of Pathology²
Chungnam National University Hospital, Daejeon, Republic of Korea

증례 : Concurrence of Fibrillary Glomerulonephritis and AL Amyloidosis Associated with Monoclonal Gammopathy

Dong Suk Chang, M.D.1, Won Ik Jang, M.D.1, Dae Eun Choi, M.D.1, Ki Ryang Na, M.D.1, Kwang Sun Suh, M.D.2, Yong Tai Shin, M.D.1 and Kang Wook Lee, M.D.1

Department of Internal Medicine1, and Department of Pathology2, Chungnam National University Hospital, Daejeon, Republic of Korea

Abstract

Renal diseases with organized deposits include amyloid, fibrillary, immunotactoid, and cryoglobulinemic glomerulopathies. AL amyloidosis and fibrillary glomerulonephritis are different in the composition of their immunoglobulin deposits. Fibrils of fibrillary glomerulonephritis are usually composed of polyclonal, occasionally oligoclonal or monoclonal, immunoglobin G, but amyloidosis consists of monoclonal light chains. Simultaneous occurrence of fibrillary glomerulonephritis and AL amyloidosis is very rare. We report a case of fibrillary glomerulonephritis combined with AL amyloidosis in a 71-yr-old man.

Key Words: Amyloidosis, Glomerulonephritis, Monoclonal gammopathy of undetermined significance