Acute Interstitial Nephritis during the First Course of Rifampin Administration in a Renal Transplant Patient

Korean Journal of Nephrology 2011;30(4):424-428.

Hyun Seung Lee, M.D.1, Hyun Joo Kim, M.D.1, Mi Seon Kang, M.D.2, Seok Ju Park, M.D.1, Tae Hee Kim, M.D.1, Sun Woo Kang, M.D.1 and Yeong Hoon Kim, M.D.1

Department of Internal Medicine¹
Department of Pathology²
Busan Paik Hospital, Inje University College of Medicine, Busan, Korea

증례 : 신장이식 환자에서 리팜핀 초치료 후 발생한 급성 간질성 신염

이현승1, 김현주1, 강미선2, 박석주1, 김태희1, 강선우1, 김영훈1

인제대학교 의과대학 부산백병원 내과학교실1 , 병리학교실2

Abstract

Tuberculosis is recognized as one of the most important complications in an organ transplant recipient. Rifampin has become a standard agent in the treatment of tuberculosis. While rifampin is well tolerated in most patients, adverse effects, including serious forms of toxicity, have been reported. Some of these adverse effects include liver toxicity and various immunologic reactions such as skin rashes, eosinophilia, and interstitial nephritis. We have experienced a case of acute interstitial nephritis during the first course of standard anti-tuberculous therapy in a renal transplant patient. We should not ignore other causes of interstitial nephritis in a renal transplant patient.

Key Words: Tuberculosis, Kidney transplantation, Rifampin, Interstitial nephritis