Korean Journal of Nephrology 2011;30(5):452-458.
Effects of Lipoxygenase Inhibitor on Diabetic Nephropathy in Rats: Decreasing Proteinuria and Preserving Renal Function
Hyun Chul Chung, M.D., Il Young Kim, M.D., Seo Rin Kim, M.D., Jungmin Son, M.D., Dong Won Lee, M.D., Sang Heon Song, M.D., Eun Young Seong, M.D., Ihm Soo Kwak, M.D. and Soo Bong Lee, M.D.
Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
원저 : Streptozotocin 투여로 유발된 당뇨병성 신증 백서에서 lipoxygenase 억제제가 단백뇨 감소 및 신기능에 미치는 영향
정현철, 김일영, 김서린, 손정민, 이동원, 송상헌, 성은영, 곽임수, 이수봉
부산대학교 의학전문대학원 내과학교실
Abstract
Purpose: Oxidative stress leads to an increased production of lipoxygenase derivatives in diabetic nephropathy. Thus, we hypothesized that lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA), ha the effects of decreasing proteinuria and preserving renal function in streptozotocin (STZ)-induced diabetic rats. Methods: 45 Sprague-Dawley rats were divided into three groups; (A) treatment with lipoxygenase inhibitor, NDGA in diabetic nephropathy rats, (B) treatment with dimethyl sulfoxide (DMSO) as a vehicle in STZ-induced diabetic rats, (C) normal control group with subcutaneous injection of normal saline. Diabetes was induced by a single intraperitoneal injection of STZ (65 mg/kg) in rats of group A and B. After the 4th week of STZ injection, NDGA (10 mg/kg) and DMSO were given subcutaneously for another 4 weeks in group A and B respectively. Results: The NDGA-treated diabetic rats exhibited significantly decreased urinary albumin excretion. Serum creatinine and blood urea nitrogen concentrations were increased in both group A and B, and tend to be higher in group B than group A. Twenty-four-hour urine creatinine clearances were increased in both group A and B after injection of STZ. Pathologic alterations of kidney were observed after injection of STZ, and then attenuated after administration of NDGA. Conclusion: These results suggest the potential of lipoxygenase inhibitor as a complementary therapy for the prevention and treatment of diabetic nephropathy.
Key Words: Diabetic nephropathy, Proteinuria, Nordihydroguaiaretic acid
TOOLS
METRICS Graph View
  • 346 View
  • 14 Download
Related articles


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#301, (Miseung Bldg.) 23, Apgujenog-ro 30-gil, Gangnam-gu, Seoul 06022, Korea
Tel: +82-2-3486-8736    Fax: +82-2-3486-8737    E-mail: registry@ksn.or.kr                

Copyright © 2022 by The Korean Society of Nephrology.

Developed in M2PI

Close layer