Three Cases of Minimal Change Nephrotic Syndrome in Patients with Type 2 Diabetes

Korean Journal of Nephrology 2010;29(1):104-109.

Jun Seok Jeon, M.D.1, Jung Eun Lee, M.D.1, Jin Hee Lee, M.D.1, Byeongho Jeong, M.D.1 A Jin Cho, M.D.1, Gee-Young Kwon, M.D.2, Wooseong Huh, M.D.1 Yoon-Goo Kim, M.D.1, Dae Joong Kim, M.D.1 and Ha Young Oh, M.D.1

Department of Medicine1 and Department of Pathology²
Samsung Medical Center Sungkyunkwan University School of Medicine

증례 : 제 2형 당뇨병 환자에서 발생한 미세변화 신증후군 3례

전준석1, 이정은1, 이진희1, 정병호1, 조아진1, 권기영2, 허우성1, 김윤구1, 김대중1, 오하영

성균관대학교 의과대학 삼성서울병원 내과1 , 병리과2

Abstract

Diabetic nephropathy is a common and serious complication of diabetes characterized by persistent proteinuria, hypertension and a progressive decline of renal function. However, non-diabetic renal disease can be present in diabetic patients and differential diagnosis of treatable disease is important.Minimal change nephrotic syndrome is characterized by normal light microscopic finding and effacement of foot process in electron microscope, but foot process effacement is not specific and it can be present in the glomeruli of the most glomerulopathy including diabetic nephropathy. Therefore, pathNephrotic syndrome, minimal change, Type 2 diabetes mellitus, Corticosteroid ologic diagnosis of minimal change nephrotic syndrome combined with diabetic nephropathy is very difficult.However, we could exclude other glomerulopathy and diagnose minimal change nephrotic syndrome by clinical features in three type 2 diabetic patients with diabetic nephropathy and have successfully treated with corticosteroid.

Key Words: Nephrotic syndrome, minimal change, Type 2 diabetes mellitus, Corticosteroid