Korean Journal of Nephrology 2010;29(4):434-440.
Outcome and Prognosis in Patients Receiving Continuous Renal Replacement Therapy
Seung Ho Lee, M.D., Soon Kil Kwon, M.D. and Hye-young Kim, M.D.
Department of Internal Medicine, Chungbuk National University, Cheongju, Korea
원저 : 지속적 신대체요법을 시행 받은 환자들의 치료 결과와 예후
이승호, 권순길, 김혜영
충북대학교 의과대학 내과학교실
Purpose: Acute kidney injury is a critical complication in patients intensive care unit (ICU) and shows high mortality. After development of continuous renal replacement therapy (CRRT), there were many conflicting data for patient survival. We want to find out which parameter shows strong correlation in the survival of patients undergoing CRRT in intensive care unit. Methods: Total 85 patients were enrolled who had been treated with CRRT in ICU. We compared the differences in clinical parameters between survivors with non-survivors. Results: Mean age of the patients was 62.0±15.6 and 57 patients were male (67.1%). Out of 85 patients, 39 patients survived (45.9%). Mean duration of CRRT was 103.5±178.8 hours and mean Acute Physiology And Chronic Health Evaluation (APACHE) III score was 90.6±22.6. There were significant differences between survivors and non-survivors in APACHE III score (p=0.004), time to initiation of CRRT (p=0.05), systolic blood pressure at initiation of CRRT (p=0.001), arterial [H+] (50.18 vs. 84.19, p=0.001), respectively. But there was no difference in the age, sex, the level of pre CRRT blood urea nitrogen, duration of ICU admission, hypoxemia and hemoglobin level. Conclusion: Earlier initiation of CRRT and protection from metabolic acidosis were strongly associated with the survival of the patient with acute kidney injury in ICU.
Key Words: Hemodiafiltration, Renal replacement therapy, Acute renal failure

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