A Case of Kaposi's Sarcoma Improved by Sirolimus Treatment 
in the Kidney Transplant Recipient

Korean Journal of Nephrology 2009;28(1):82-87.

A Case of Kaposi's Sarcoma Improved by Sirolimus Treatment in the Kidney Transplant Recipient

Seung Min Lee, M.D.1, So Yeon Park, M.D.1, Soo Jin Kim, M.D.1, Young Soo Song, M.D.1, Heon Ho Song, M.D.1, Samuel Lee, M.D.2, Eun Sook Nam, M.D.3 and Jieun Oh, M.D.1

Department of Internal Medicine, Kidney Research Institute1 and Gerenal Surgery2 and Pathology3 Hallym University College of Medicine, Seoul, Korea.

증례 : 신장 이식 후 발생한 Kaposi 육종에서 sirolimus와 vincristine으로 치료한 1예

이승민1, 박소연1, 김수진1, 송영수1, 송헌호1, 이삼열2, 남은숙3, 오지은1

한림대학교 의과대학 강동성심병원 내과1, 외과2, 병리과3

Abstract

The incidence of Kaposi's sarcoma (KS) increases in kidney transplant recipients who had the immunosuppressive therapy. The usual treatment of KS is to reduce the dosage of immunosuppressive agents, with chemotherapy and/or radiotherapy. Several studies have recently demonstrated that the conversion to proliferation signal inhibitors (PSIs) from calcineurin inhibitors (CNI) leads to the remission of some post-transplant tumors such as KS. PSIs were well tolerated with stable renal function and no episode of acute rejection was reported. On the basis of these findings, we report a case of Kaposi's sarcoma in the kidney transplant patient, who had multiple lymphadenopathy and hepatic involvement without skin lesions. This patient responded well to the change of the immunosuppressive treatment from cyclosporine to sirolimus, one of PSIs.

Key Words: Kaposi's sarcoma, Kidney transplantation, Sirolimu