| A Long-term Study On Changes of Serum Middle Molecules Concentration according to the Frequency of On-line Hemodiafiltration -A Comparison between 1/week and 3/week On-line Hemodiafiltration- |
| yung-Eun Lee, M.D.1, Tae-Young Kim, M.D.1, Woo-Jin Nam, M.D.1, Sun-Min Kim, M.D.1, Jung-Ho Shin, M.D.1, Jihyun Ahn, M.D.1, Su-Hyun Kim, M.D.1, Dong-Jin Oh, M.D.1, Suk-Hee Yu, M.D.1 and Eung-Tack Kang, M.D.2 |
Department of Internal Medicine, Chung-Ang University College of Medicine1
and Kang's Dialysis Center2
Seoul, Korea |
| 임상연구 : 온-라인 혈액여과투석법 빈도에 따른 중분자 물질의 혈중 농도 변화에 관한 장기 연구 - 주 1회 및 3회 온-라인 혈액여과투석법 비교 - |
| 이경은1, 김태영1, 남우진1, 김선민1, 신정호1, 안지현1,, 김수현1, 오동진1, 유석희1, 강응택2 |
| 중앙대학교 의과대학 내과학교실1, 강의내과2 |
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| Abstract |
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Purpose:The purpose of this study was to assess the effect of long-term and differing frequency of on-line hemodiafiltration (OL-HDF) on changes in degree of hemoglobin, albumin level, serum small and middle molecules concentration in stable patients with undergoing high-flux hemodialysis (HF-HD).
Methods:Twenty five patients with more than 3 months of HF-HD were divided into two groups and followed for more than 36 months. Group 1 was treated once with OL-HDF and twice with HF-HD per week. Group 2 was treated three times with OL-HDF per week. Analysis was performed to compare hemoglobin, biochemical parameters, serum β2-microglobulin, leptin, α1-microglobulin levels in both groups.
Results:There were significant improvements in hemoglobin and albumin level in group 2 compared to group 1. After receiving OL-HDF for a mean of 24 months, patients on both groups had the significantly reduced predialysis level of β2-microglobulin compared to baseline level. However, there is no significant difference in β2-microglobulin level between both groups. The predialysis level of leptin and α1-microglobulin with relatively large molecular weight was not significantly reduced during observational period and was not significantly different between both groups.
Conclusion:There were improvements in hemoglobin and albumin level according to the frequency of OL-HDF. The predialysis level of β2-microglobulin was significantly reduced after receiving even once with OL-HDF per week for long-term. Therefore, our study can suggest that there is no correlation between the frequency of OL-HDF and the predialysis level of β2-microglobulin. |
| Key Words:
Hemodiafiltration, Hemodialysis, Beta 2-microglobulin |
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