Korean Journal of Nephrology 2008;27(1):46-54.
Clinicopathologic Findings in Obesity-related Glomerulopathy
Eun Kyung Park, M.D.1, Yeong Seop Yun, M.D.1, Soon Hyo Kwon, M.D.1, Jin Seok Jeon, M.D.1 Hyun Jin Noh, M.D.1, Sun Young Lee, M.D.1, So Young Jin, M.D.2 and Dong Cheol Han, M.D.1
Hyonam Kidney Laboratory1 and Department of Pathology2 Soon Chun Hyang University College of Medicine, Seoul, Korea
원저 : 비만관련 사구체병증의 임상병리학적 고찰
박은경1•윤영섭1•권순효1•전진석1•노현진1•이선영1•진소영2•한동철1
순천향대학교 의과대학 현암신장연구소1, 병리학교실2
Abstract
Purpose : Recently, obesity with metabolic syndrome is considered as an important risk factor in the development and progression of chronic kidney disease (CKD). Glomerulomegaly and focal segmental glomerulosclerosis (FSGS) are found in the obese patients, suggesting that investigation of structuralfunctional relationship in the obesity-related glomerulopathy (ORG) is needed to prevent CKD. Thus, we report here clinical and pathologic characteristics of ORG and its association with other clinical variables. Methods : Obesity was defined by body mass index >25 kg/m2 and ORG morphologically by FSGS and glomerulomegaly or glomerulomegaly alone. Clinicopathologic findings and glomerular sizes of ORG (14 cases) were compared with age-matched controls with thin basement membrane disease. Multiple variable analysis was performed between glomerular size and clinical variables. Results : There was no nephrotic syndrome or pretibial pitting edema in all obese patients. Mean glomerular diameter was increased in obese patients compared to controls (240±21 μm vs 197±21 μm, p=0.001). Seven cases had lesions with FSGS with glomerulomegaly and seven cases glomerulomegaly alone. Mild tubular atrophy, interstitial fibrosis and arteriolosclerosis were observed in more than half of patients. In obese patients, seven patients with FSGS had more elevated systolic blood pressure and tubular interstitial fibrosis compared to patients with glomerulomegaly only. Patients' systolic blood pressure and waist circumference were independent risk factors influencing the glomerular size in obese patients. Conclusion : FSGS or glomerulomegaly are prominent even in the mild obesity with insignificant clinical symptoms. This indicates that the clinical attention to glomerular disease is needed in obese patients.
Key Words: Obesity, Glomerulosclerosis, Focal segmental, Nephrotic syndrome
TOOLS
METRICS Graph View
  • 619 View
  • 13 Download
Related articles

Clinicopathologic Characteristics of C1q nephropathy2010 March;29(2)



ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#301, (Miseung Bldg.) 23, Apgujenog-ro 30-gil, Gangnam-gu, Seoul 06022, Korea
Tel: +82-2-3486-8736    Fax: +82-2-3486-8737    E-mail: registry@ksn.or.kr                

Copyright © 2024 by The Korean Society of Nephrology.

Developed in M2PI

Close layer