A Case of Interstitial Pneumonitis Associated withSirolimus Treatment in Renal Transplantation Recipient

Korean Journal of Nephrology 2008;27(5):611-615.

Ji Young Lee, M.D., Sun Young Kim, M.D., Seung Woon Byun, M.D., Young Sun Yeo, M.D., Jai Won Chang, M.D., Won Seok Yang, M.D., Soon Bae Kim, M.D., Jung Sik Park, M.D. and Su-Kil Park, M.D.

Department of Internal Medicine, ASAN Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea

증례 : 신 이식 환자에서 Sirolimus 투여 후 발생한 간질성 폐렴 1예

이지영, 김선영, 변승운, 여영선, 장재원, 양원석, 김순배, 박정식, 박수길

울산대학교 의과대학 서울아산병원 신장내과

Abstract

Sirolimus is a promising immunosuppressive drug for renal transplantation to avoid nephrotoxicity of calcineurin inhibitor. However, it has been associated with uncommon but, important pulmonary toxicity. We present a case of sirolimus related dyspnea with abnormal chest radiographic finding in a 63 year old male renal transplantation recipient. There was no evidence of bacterial, fungal, or viral infection. Dose reduction of sirolimus resulted in a significant improvement of the symptoms and chest radiographic finding.

Key Words: Sirolimus, Kidney transplantation, Pneumonitis, Adverse effects