Korean Journal of Nephrology 2008;27(6):726-732.
The Effectiveness of Sequential Intravenous Saline and Oral Water Loading Tests and Barsoum-Levine Formula for Managing Hyponatremic Patients: 2 Case Reports
Joo-Hark Yi, M.D., Won-Jun Kim, M.D., U-Seok Noh, M.D., Yeon-Jae Kim, M.D., Young-Sun Ko, M.D., Sang-Woong Han, M.D. and Ho-Jung Kim, M.D.
Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea
증례 : 저나트륨혈증 환자의 진단과 치료에서 연속적인 생리식염수 및 수분 부하검사와 Barsoum-Levine 공식의 유용성
이주학, 김원준, 노유석, 김연재, 고영선, 한상웅, 김호중
한양대학교 구리병원 내과
Abstract
In hyponatremic patients, the assessment of extracellular fluid volume plays an essential step in diagnosing the etiology of hyponatremia and deciding how to manage it. Although various laboratory tests and diagnostic procedures have been developed for differential diagnosis of hyponatremia, there still are limits to the evaluation of the status of extracellular fluid volume due to the data that overlaps each other, leading to the difficulty in diagnosing between euvolemia and hypovolemia. Also, there is no consensus about how to guide the type and amount of fluid therapy despite many formulas including Adrogue-Madias and Barsoum-Levine formulas have been suggested. Hereby, we are reporting two hyponatremic patients (102 and 105 mEq/L) admitted simultaneously with indistinct volume status on initial clinical and laboratory examinations, but were clarified as euvolemic hyponatremia (syndrome of inappropriate antidiuretic hormone secretion) in one and hypovolemic hyponatremia in the other case after sequential intravenous saline (2 L over 24 hrs) and oral water (20 mL/kg) loading tests. When serum sodium values calculated by the above-mentioned two formulas were compared with actually measured ones during saline loading test in these cases, the Barsoum-Levine formula revealed almost no discrepancy between both the values while the Adrogue-Madias formula underestimated the measured value.
Key Words: Hyponatremia, Formula, Inappropriate ADH syndrome
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