Korean Journal of Nephrology 2007;26(3):382-385.
A Case of Acute Lithium Intoxication Treated with Continuous Venovenous Hemodiafiltration
Soon-Young Ko, M.D.1, Tae-Ho Seo, M.D.1, Seung-Min Lee, M.D.1, Jung-Hwan Park, M.D.1 Young-Il Jo, M.D.1, Seung-Ho Yoo, M.D.2 and Jong-Ho Lee, M.D.1
Department of Internal Medicine1
Psychiatry2 , Konkuk University Hospital Konkuk University School of Medicine, Seoul, Korea
지속성 정정맥 혈액투석여과로 치료한 급성 리튬 중독 1예
고순영1 서태호1 이승민1 박정환1 조영일1 유승호2 이종호1
건국대학교 의학전문대학원 건국대학교병원 내과학교실1, 신경정신과교실2
Abstract
Lithium is commonly used for the treatment of bipolar affective disorders. Lithium therapy has a narrow therapeutic window, which can lead to various neurologic, cardiovascular, and renal side effects. Dialysis is recommended for the treatment of severe lithium toxicity, but conventional hemodialysis can cause post-dialysis rebound of serum lithium level. We report a case of lithium intoxication in which continuous venovenous hemodiafiltration (CVVHDF) was successfully used in reducing toxicity. CVVHDF provides excellent lithium clearance, and prevents post-therapy lithium rebound by allowing a progressive removal of intracellular lithium. It could become a modality of choice for lithium intoxication.
Key Words: Lithium, Dialysis, Hemodiafiltration


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