| A Case of Post-Transplant Lymphoproliferative Disorder Presenting with Hydronephrosis after Kidney Transplantation |
| Yong Gu Lee, M.D.1, Joon-Sung Park, M.D.1, Chang-Hwa Lee, M.D.1, Gheun-Ho Kim, M.D.1 Chong-Myung Kang, M.D.1 and Chan-Gheum Park, M.D.2 |
| Departments of Internal Medicine1 and Pathology2 Hanyang University Hospital, Seoul, Korea |
| 요관 폐쇄에 의한 물콩팥증으로 발현한 이식후림프세포증식질환 1예 |
| 이용구1 박준성1 이창화1 김근호1 강종명1 박찬금2 |
| 한양대학교 의과대학 내과학교실1, 병리학교실2 |
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| Abstract |
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Lymphoproliferative disorders are among the most serious and potentially fatal complications of chronic immunosuppression in organ transplant recipients. Post-transplant lymphoproliferative disorder (PTLD) is the second common malignancy occurring in patients with kidney transplantation and has a high mortality rate. The pathogenesis of PTLD in most cases appears to be related to B cell proliferation induced by infection with Epstein-Barr virus (EBV) in the setting of chronic immunosuppression. The PTLD may present a solitary tumor around the hilum of transplant kidney, but it may not by easily considered as the cause of hydronephrosis in transplant kidney because the prevalence of PTLD is low and surgical complications such as lymphocele, stricture and hematoma that obstruct the transplant ureter are much more common. Early detection is important because reduction of immunosuppressive agents may reverse progression of the disease. Furthermore, several effective treatment options were recently introduced. Here we report a case of PTLD presenting with hydronephrosis, which was completely resolved by a multimodality therapeutic approach. |
| Key Words:
Lymphoproliferative disorders, Hydronephrosis, Kidney transplantation |
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