| A Case of Successful Third Renal Transplantation Using Rituximab (anti-CD20 Monoclonal Antibody) in a Highly Sensitized Patient |
| Su Jin Moon, M.D., Su Hyun Kim, M.D., Hye Eun Yoon, M.D., Yong Kyun Kim, M.D. Bum Soon Choi, M.D., Chul Woo Yang, M.D., Yong Soo Kim, M.D. and Byung Kee Bang, M.D. |
| Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea |
| 감작된 환자에서 rituximab 유도 요법을 이용한 3차 신장 이식 1례 |
| 문수진 김수현 윤혜은 김용균 최범순 양철우 김용수 방병기 |
| 가톨릭대학교 의과대학 내과학교실 |
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| Abstract |
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Rituximab, chimeric murine/human anti-CD20 monoclonal antibody, has been currently used as treatment of follicular non-Hodgkins lymphoma and posttransplantation lymphoproliferative disease. Nowadays, rituximab has also been utilized in the renal transplantation to get over acute rejection in highly sensitized patients. We hereby report a case of successful renal transplantation in a highly sensitized patient, who has been done the 3rd renal transplantation. A 44-year-old male patient admitted for the 3rd renal transplantation. His previous 2 transplantations failed because of acute rejection. We tried plasmapheresis and intravenous immunoglobulin, widely used as pretransplantation management in high risk patients. In addition to these, we applied 2 times of rituximab (375 mg/m2) before transplantation at interval of 1 week. The renal function of the patient has been within the normal range without any evidence of rejection 6 months after transplantation. |
| Key Words:
Rituximab, Graft rejection, Renal transplantation |
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