| Methylprednisolone Pulse Therapy in Adult-Onset Minimal Change Nephrotic Syndrome |
| Sook Eui Oh, M.D.1, Young Ki Lee, M.D.1, Jin Kyung Kim, M.D.1, Sung Tae Cho, M.D.1 Rho Won Chun, M.D.1, Jong Woo Yoon, M.D.1, Ja Ryong Koo, M.D.1 , Hyung Jik Kim, M.D.1 Jung Woo Noh, M.D.1 and Eun Suk Nam, M.D.2 |
| Department of Internal Medicine, Kidney Research Institute1 and Department of Pathology2 College of Medicine, Hallym University, Seoul, Korea |
| 원저 : 성인 미세변화신증후군 환자에서 스테로이드 충격요법의 효과 |
| 오숙의1 이영기1 김진경1 조성태1 전로원1 윤종우1 구자룡1 김형직1 노정우1 남은숙2 |
| 한림대학교 의과대학 내과학교실, 신장연구소1, 병리학교실2 |
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| Abstract |
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Purpose : The incidence of complete remission is lower and the relapse is more frequent in adult-onset minimal change nephrotic syndrome (MCNS) are observed especially when compared with those in children. This study was designed to examine the effect of methylprednisolone pulse therapy in adultonset MCNS comparing to oral steroid as an initial therapeutic modality.
Methods : We have retrospectively reviewed the clinical data of 25 adult-onset MCNS patients. Twelve patients were treated with three intravenous pulses of methylprednisolone (1 g daily) followed by oral prednisolone 1 mg/kg daily for 4-8 weeks and also by low doses of oral prednisolone for 4-6 months (MP group) Thirteen patients were initially treated with oral prednisolone 1 mg/kg daily for 4-8 weeks and then with low doses of oral prednisolone (PD group).
Results : The response to therapy was similar between MP and PD group, with a complete remission obtained in 83.3% and 84.6%, respectively. No statistically significant difference between the two groups was observed in the rate of response at 8 weeks (58.3% versus 69.2%). The mean time to response was not different between MP group (37.9±28.0 days) and PD group (45.5±40.2 days). No difference was recognized between the two groups with respect to relapse rate.
Conclusion : These data suggest that a short course of methylprednisolone pulse therapy followed by oral prednisolone is not superior to oral prednisolone therapy as an initial therapeutic modality in adult-onset MCNS.
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| Key Words:
Minimal change nephrotic syndrome, Methylprednisolone, Pulse |
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