1. Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells.
Diabetologia 2009;52:1083–1086.
2. Hartleben B, Gödel M, Meyer-Schwesinger C, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
J Clin Invest 2010;120:1084–1096.
3. Kimura T, Takabatake Y, Takahashi A, et al. Autophagy protects the proximal tubule from degeneration and acute ischemic injury.
J Am Soc Nephrol 2011;22:902–913.
4. Jiang M, Liu K, Luo J, Dong Z. Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
Am J Pathol 2010;176:1181–1192.
5. Kume S, Uzu T, Horiike K, et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
J Clin Invest 2010;120:1043–1055.
6. Ohsumi Y, Mizushima N. Two ubiquitin-like conjugation systems essential for autophagy.
Semin Cell Dev Biol 2004;15:231–236.
7. Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations.
Nat Cell Biol 2007;9:1102–1109.
8. Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Proc Natl Acad Sci U S A 1992;89:2399–2403.
9. Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
Food Chem Toxicol 1999;37:973–979.
10. Misiewicz I, Skupińska K, Kowalska E, Lubiński J, Kasprzyc-ka-Guttman T. Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells.
Acta Biochim Pol 2004;51:711–721.
11. McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
J Biol Chem 2003;278:21592–21600.
12. Eggler AL, Gay KA, Mesecar AD. Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.
Mol Nutr Food Res 2008;52(Suppl 1):S84–S94.
13. Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
Mol Cell Biol 2003;23:8137–8151.
14. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease.
Int J Biochem Cell Biol 2007;39:44–84.
15. Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment.
Antioxid Redox Signal 2009;11:777–790.
16. Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy.
Cell Death Differ 2009;16:1040–1052.
17. Huang J, Canadien V, Lam GY, et al. Activation of antibacterial autophagy by NADPH oxidases.
Proc Natl Acad Sci U S A 2009;106:6226–6231.
18. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.
EMBO J 2007;26:1749–1760.
19. Singh SV, Srivastava SK, Choi S, et al. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.
J Biol Chem 2005;280:19911–19924.
20. Xiao D, Powolny AA, Antosiewicz J, et al. Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.
Pharm Res 2009;26:1729–1738.
21. Lee YJ, Lee SH. Sulforaphane induces antioxidative and an-tiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.
J Korean Med Sci 2011;26:1474–1482.
22. Naumann P, Fortunato F, Zentgraf H, Büchler MW, Herr I, Werner J. Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer.
Int J Oncol 2011;39:101–109.
23. Law BY, Wang M, Ma DL, et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis.
Mol Cancer Ther 2010;9:718–730.
24. Zhu J, Wang KZ, Chu CT. After the banquet: mitochondrial biogenesis, mitophagy, and cell survival.
Autophagy 2013;9:1663–1676.
25. Petersen M, Hofius D, Andersen SU. Signaling unmasked: autophagy and catalase promote programmed cell death.
Autophagy 2014;10:520–521.
26. Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.
J Cell Sci 2007;120:4155–4166.
27. Yu L, Wan F, Dutta S, et al. Autophagic programmed cell death by selective catalase degradation.
Proc Natl Acad Sci U S A 2006;103:4952–4957.
28. Bolisetty S, Traylor AM, Kim J, et al. Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury.
J Am Soc Nephrol 2010;21:1702–1712.
29. Kim HP, Wang X, Chen ZH, et al. Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1.
Autophagy 2008;4:887–895.
30. Periyasamy-Thandavan S, Jiang M, Wei Q, Smith R, Yin XM, Dong Z. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells.
Kidney Int 2008;74:631–640.
31. Yang C, Kaushal V, Shah SV, Kaushal GP. Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells.
Am J Physiol Renal Physiol 2008;294:F777–F787.
32. Wu Y, Zhang Y, Wang L, Diao Z, Liu W. The role of au-tophagy in kidney inflammatory injury via the NF-κB route induced by LPS.
Int J Med Sci 2015;12:655–667.
33. Banerjee P, Basu A, Wegiel B, et al. Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules.
J Biol Chem 2012;287:32113–32123.
34. Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential.
Biochem Pharmacol 2010;80:1895–1903.