Korean Journal of Nephrology 1995;14(1):35-42.

낭창성 신염 환자에서 Ga-scintigram의 의의

이준상 , 양용석 , 이재복 , 김성일 , 김인주 , 홍택종 , 곽임수 , 나하연 , 손성표

Abstract

Background
We studied to evaluate the realationship between disease activity of lupus nephritis and renal uptake of Ga 67 citrate. Methods.: The relationship between the renal accu- mulation of Ga 67 citrate and pathological or clinical parameters of lupus nephritis was analyzed in thir- teen SLE patients. The renal uptake of Ga-67 citrate was graded from o to 4th degree. The patients were divided to two groups according to the degree of Ga 67 citrate renal uptake. Group I patients had 0, first, and second degree renal uptake of gallium and Group II patients had third to fourth degree of renal gallium uptake. Results :. 1) 7 out of 13 patients had lupus nephritis, among them 5 patients had renal uptake of Ga 67 citrate above grade 3(Group II ). The other 2 patients and 6 patients without lupus nephritis had renal uptake below grade 2(Group I ). 2) Renal disease activity in group II patients was significantly higher than that in group I patients(7. 6±1.1 vs 2.4± 1.4, p<0.05). And the degree of renal Ga 67 citrate uptake was correlated positively with real disease activity(r=0.9, p<0.05). 3) The serum creatinine value of group II (2.16± 1.3mg/dl) tended to be higher than that of group I (0.7±0.1mg/dl), but there was no statisticall signifi- cance. 4) The blood pressure of group II (136 ± 11/86 ±5 17mmHg) tended to be higher than thst of group I (109±14/69±11mmHg), but there was no statical significance. 5) The amount of 24 hour urine protein excretion of group II(3.4@k1.5gm/day) were higher than that of group I (0.7±0.6gm/day) significantly(p<0.05). 6) The serum C and C< level of group II patients (18.1± 15.5mg/dl andl 10.1 ±5.3mg/dl) tended to be lower than those of group I patients(26.5 ± 18.7mg/ dl andl 15.0±5.3mg/dl) but, there was no statical signif icance. 7) Renal biopsy was done in 5 patients of group II, the findings were diffuse proliferative lupus GN in 4 cases and mesangial lupus GN in 1 case. Conclusion:. We can suggest that Ga 67 citrate scan is useful to diagnose and to estimate the activity of lupus nephritis.