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| 앤지오텐신성 혈압 상승이 Norepinephrine에 대한 신혈관 감수성에 미치는 영향 |
| 한지희 , 민영기 , 양훈모 |
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| Abstract |
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To determine to effect of angiotensin Il (ANG II )-induced hypertension on the renovarcular respones to norepinephrine (NE), six anesthetized dogs instrumented for monitoring of renal blood flow (RBF) were subjected to step increases every 2 minutes in the rate of norepinephrine infusion into the renal artery during 1) control conditions(C), 2) servocontrol of renal arterial pressure (RAP) at levels expected to be achieved during acute captopril administration(C+S), 3) acute captopril administ- ration(CEI), 4) angiotensin II infusion simultaneously with captopril at concentrations which restored RAP toward control (CEI+A), and 5) servocontrol of RAP during captopril and angiotensin II (SEI+A+S). Whether the plasma levels of ANG II were allowed to increase(C, C+S) or not (CEI+A, CEI+A+S) with NE infusion, there were no differences in RBF response to NE infusion between C and C+S and between CEI+A and CEI+A+S, which implies that RAP does not play an important role in modulating the renovascular response to NE. However, when captopril was administered without ANG II repla- cement (CEI), RBF induced severe renal ischemia at much lower rates of NE infusion than occurred when the sufficient concentration of ANG II were present in the plasma. Since this enhanced sensitivity to NE did not occur at RAP's lower than those achieved during acute captopril administration once ANG II was present in the plasma in sufficient concentrations, it is likely that ANG II exerts a protective effect on the kidney during renal adrenergic stimulation through a mechanism other than increasing systemic arterial pressure. |
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