|
| 복막투석 환자에서 Netilmicin의 양측성 복막이동에 관한 약동학적 연구 |
| 신재국 , 장인진 , 신상구 , 김경수 , 박민선 , 황승덕 , 이선희 |
|
|
| Abstract |
|
To analyse transport of netilmicin through perito- neum and establish appropriate dosage guideline in CAPD patients with peritonitis, we studied pharmaco- kinetics of netilmicin in 8 patients undergoing CAPD for chronic renal failure. 100 mg single loading or 20 mg maintenance dose was administered to these patients through dialysis fluid. Netilmicin concentrations of serum and dialysis fluid were measured by fluorescence polarizing immunoassay, and the data were subjected to computer analysis using two compartment model which considered the bidirectional flux of the drug. Distributional clearance of plasma to dialysis fluid (Cl ), clearance of dialysis fluid to plasma (Cl) and mean dialysis clearance (Cl.) were 5.99±2.83, 11.56±3.43 and 3.59±1.41 ml/hr/kg, respectively. Volume of distribu- tion of netilmicin in these patients were 0.34±0.12 L/kg and systemic clearance (Cl) was 6.81±2.90ml/hr/kg. Bioavailability, which was assessed by the remaining amount at 6 hr after intraperitoneal administration, was 0.75±0.10. Estimated half-life of netilmicin during end stage renal disease reduced from 39.7 to 23.6 hours by CAPD. Simulated mean steady-state peak and trough netilmicin concentrations after 20 mg maintenance dose administration per 6 hours were 5.4 and 5.2 ug/ml, re- spectively. A dosing guide, loading and maintenance dose, using l the pharmacokinetic data obtained from this study is presented. |
|
PDF Links
Download Citation
