Korean Journal of Nephrology 1987;6(1):140-146.

혈관조영제 투여가 신장에 미치는 영향

고철우 , 정명희 , 이상범 , 구자훈 , 김정철 , 정태호

Abstract

A prospective study was conducted to determine the degree of renal involvement in children after infusion of rediocontrast dye. Study population comprised 29 chil- dren with congenital heart diseases who had been admit- ted to the Pediatric department of Kyungpook National University Hospital from July to August 1985, and in whom cardiac catheterization with Angiografin (meg- lumine diatrizoate) was done. Obvious underlying renal diseases on these children were excluded by negative findings on blood urea nitrogen, creatinine and urin- alysis. Serial determination of urinary NAG before, and 6, 12, 72 hours after contrast dye infusion was done, and the following results were obtained. : Urinary NAG level before and 6, 12, 72 hours after contrast dye infusion showed 8.79±7.15, 20.06±14.16, 19. 38±12.01 and 11.48±7.03 nM/min/mg creatinine respec- tively, and this changing pattern of NAG level showed statistical significance by analysis of variance (F=7.74, p<0.01). Furthermore, urinary NAG level at 6 and 12 hours after dye infusion showed more elevated values in children with cyanotic congenital heart disease as compared with noncyanotic one, indicating that patients with cyanotic congenital heart disease is more prone to the development of renal damage by radiocontrast dye. However, urinalyis done at the same interval disclosed normal findings. Therefore, from this study, it can be concluded that the use of radiocontrast dye in children with congenital heart disease should be very cautious and the dye has to be the smallest amount as possible to reduce its ne- phrotoxic effect to the minimum.