| The Prevalence of Chronic Kidney Disease and the Predictors of Decreased Kidney Function in Hypertensive Patients |
| Sejoong Kim, M.D. Ph.D., Young Rim Song, M.D., Ho Jun Chin, M.D, Ph.D. Yoon Kyu Oh, M.D., Ph.D, Kook Hwan Oh, M.D., Ph.D., Kwon Wook Joo, M.D., Ph.D. Ki Young Na, M.D., Ph.D., Yon Su Kim, M.D., Ph.D., Curie Ahn, M.D., Ph.D. Jin Suk Han, M.D., Ph.D., Suhng |
| Department of Internal Medicine Seoul National University College of Medicine |
| 원저 : 고혈압 환자에서 만성 신질환의 유병율과 신기능 감소의 예측인자 |
| 김세중•송영림•진호준•오윤규•오국환•나기영•주권욱 춘수•김연수•안규리•한진석•김성권•채동완 |
| 서울대학교 의과대학 내과학교실 |
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| Abstract |
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Purpose : Hypertension (HT) has been known to play an important role in progression of chronic kidney disease (CKD). However, limited data are available in Korean HT patients. We evaluated the prevalence of CKD and the predictors of decrease in kidney function (DKF) in HT patients.
Methods : We retrospectively analyzed the medical records of outpatients with HT in Bundang Seoul National University hospital. DKF was defined as annual loss of estimated glomerular filtration rate (eGFR) more than 7% of baseline eGFR.
Results : The prevalence of CKD was 51% in 981 total participants. In HT patients without CKD (NCKD-HT), the incidence of DKF was 46.2%. The incidence of DKF in HT patients with CKD (CKDHT) was 40.8%. Age was only baseline risk factor of DKF in NCKD-HT group. In multifactorial analysis, history of diabetes mellitus (odds ratio [OR], 2.99; 95% Confidence Interval [CI], 1.88±4.78), hemoglobin levels (OR, 0.86; 95% CI, 0.76±0.98), proteinuria (OR, 1.86; 95% CI, 1.16±2.98), and hematuria (OR, 1.62; 95% CI, 1.02±2.58) were related to DKF in CKD-HT group.
Conclusion : We suggest that the prevalence of CKD in HT patients is high and DKF is frequent in both NCKD-HT and CKD-HT groups. The pattern of the predictors of DKF shows the difference between the two groups. Especially diabetes, abnormal urinalysis, and anemia are strongly associated with DKF in CKD-HT group.
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| Key Words:
Chronic renal insufficiency, Hypertension, Risk factor |
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