| Association of Depression with Inflammation and Cardiovascular Risk Factors in End Stage Renal Disease Patients on Hemodialysis |
| Young-Youl Hyun, M.D., Sun-Chul Kim, M.D., Se-Won Oh, M.D., Jin-Joo Cha, M.D., Hye-Won Kim, M.D., Jae-Won Lee, M.D., Yoon-Seok Choi, M.D., Hye-Min Choi, M.D., Chang-Su Boo, M.D., Gang-Jee Ko, M.D., Sang-Kyung Jo, M.D., Won-Yong Cho, M.D. and Hyoung-Kyu Ki |
| Department of Internal Medicine, Korea University College of Medicine, Korea |
| 임상연구 : 혈액투석 환자의 우울 증상과 염증반응 및 심혈관 질환 위험 인자의 연관성 |
| 현영율, 김선철, 오세원, 차진주, 김혜원, 이재원, 최윤석, 최혜민, 부창수, 고강지, 조상경, 조원용, 김형규 |
| 고려대학교 의과대학 내과학교실 |
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| Abstract |
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Purpose : Depression is associated with increased inflammation and cardiovascular disease. And in patients with end stage renal disease (ESRD), depression is a common problem and cardiovascular disease is the main cause of death. The aim of this study is to investigate the association of depression with various inflammatory markers and with some cardiovascular risk factors in ESRD patients on hemodialysis
Methods : 53 patients with ESRD on maintenance hemodialysis were divided into depressive symptom (BDI≥11) group and control (BDI<11) group by the 21-items Becks depression inventory (BDI). We collected patients characteristics and laboratory measurements by medical records. And then, we measured the levels of IL-10 and TNF-αaand analyzed the genotype of IL-10 and TNF-αapromoter area.
Results : The levels of TNF-α, CRP and ferritin were significantly higher in depressive symptom group (p=0.001, 0.04, 0.02) and IL-10 concentration tended to be lower in depressive symptom group (p=0.05). The prevalence of left ventricular hypertrophy was higher in depressive symptom group than in the control group (44% vs 9%, p=0.01). GG genotype known as high IL-10 producer was less common in depressive symptom group than in control group (8% vs 36%, p=0.039).
Conclusion : Increased inflammation, high left ventricular hypertrophy prevalence and low ejection fraction were observed in depressive hemodialysis patients. Further prospective study is needed to clarify the role of depression in the development of inflammation and cardiovascular disease in ESRD patients.
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| Key Words:
Depression, Hemodialysis, Inflammation, Cardiovascular disease |
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