| A Case of Acute Interstitial Nephritis Complicated with Continuous Rifampin Therapy |
| Hyun Jung Kim, M.D.1, Jeong Min Cha, M.D.1, Duk Eun Jung, M.D.1, Ji Eun Lee, M.D.1, Yu Min Lee, M.D.1, Jin Ho Shin, M.D.1, Seung Jae Byun, M.D.2, Ju Hung Song, M.D.1 and Seon Ho Ahn, M.D.1 |
Department of Internal Medicine1
Wonkwang University School of Medicine, Iksan, Korea, Department of Surgery2
Wonkwang University School of Medicine, Iksan, Korea |
| 증례 : 지속적인 리팜핀 초치료와 관련된 급성 간질성 신염 |
| 김현정1, 차정민1, 정덕은1, 이지은1, 이유민1, 변승재2, 송주흥1, 안선호1 |
| 원광대학교 의과대학 내과학교실1, 외과학교실2 |
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| Abstract |
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Acute renal failure caused by rifampin typically occurs on intermittent administration or reintroduction of the drug. However, acute kidney injury (AKI) due to rifampin has been rarely reported to occur in patients receiving a continuous rifampin therapy. We have experienced a case of acute interstitial nephritis during the first course of standard anti-tuberculous therapy, including continuous rifampin therapy in daily dose. Forty-five-year-old male, who had been being treated with anti-tuberculous medication including rifampin (600 mg/day), was admitted to our hospital because of generalized edema and dyspnea by acute renal failure. His past medical history was unremarkable. Since the creatinine level was still elevated in 10 days after cessation of rifampin, we performed renal biopsy.
The renal pathologic findings revealed acute interstitial nephritis. After that, the patient symptom was relieved and serum creatinine level was decreased without specific therapy. The renal function was recovered at 1 month after withdrawal of rifampin. We report a case of acute interstitial nephritis complicated with the first daily rifampin therapy, along with the review of literature. |
| Key Words:
Rifampin, Interstitial nephritis, Acute renal failure |
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