Vitamin D Receptor Genotype is Associated with Secondary Hyperparathyroidism in Hemodialysis Patients

Korean Journal of Nephrology 2007;26(3):320-326.

Su In Yoon, M.D., Tae Keun Oh, M.D., Soon Kil Kwon, M.D. and Hye-Young Kim, M.D.

Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea

혈액투석 환자에서 비타민 D 수용체 유전자 다형성이 이차성 부갑상샘항진증에 미치는 영향

윤수인 오태근 권순길 김혜영

충북대학교 의과대학 내과학교실

Abstract

Purpose : It is known that secondary hyperparathyroidism in end stage renal disease (ESRD) patients is associated with vitamin D receptor (VDR) gene polymorphism, but there is no consensus on its genotype. There is lack of data in Ca, P, calcitriol and VDR polymorphism. Methods : We measured serum Ca, P, alkaline phosphatase, parathyroid hormone (PTH), and 1,25 (OH)2D3 of the 53 hemodialysis patients. The genotypes of VDR were classified BB, Bb, bb according to restriction patterns in PCR of the patients' DNA using Bsm I restriction enzyme. Results : The patients with BB, Bb, bb type were 0 (0%), 15 (28.3%), 38 (71.7%) respectively. Serum PTH levels were 70.0±63.3 pg/mL and 146.9±184.9 pg/mL in Bb, bb type respectively, and showed significant statistical difference (p<0.05). Serum 1,25 (OH)2D3 levels were 7.68±3.41 pg/mL and 6.59 ±2.67 pg/mL in Bb and bb genotype respectively without statistical significance. And there was no significant statistical differences among the serum levels of calcium, phosphorus, alkaline phosphatase. Conclusion : Vitamin D receptor gene polymorphism is associated with secondary hyperparathyroidism in hemodialysis patients, and the b allelle is suggestive of poorer bone mineral metabolism.

Key Words: Hyperparathyroidism, Receptors Calcitriol, Polymorphism Genetic, Renal dialysis