Korean Journal of Nephrology 2001;20(4):719-722.

증례 : 신 이식 후 Parvovirus B19 감염에 의한 적혈구무형성증 1 예 (Case Reports : Pure Red Cell Aplasia Due to Parvovirus B19 in Renal Transplants)

이정익(Jeong Ik Lee),강태영(Tae Young Kang),조한표(Han Pyo Cho),윤창옥(Chang Ok Yoon),정청일(Chung Il Jung),이숙진(Sook Jin Lee),강문수(Mun Su Kang),이창화(Chang Hwa Lee),강경원(Kyoung Won Kahng),박찬현(Chan Hyun Park),강종명(Chong Myung Kang),이웅수(Woon

Abstract

Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts, including organ transplant recipients. We report a case of pure red cell aplasia caused by parvovirus B19 in renal transplants. The patient was 16-year-old male who was diagnosed as chronic renal failure 7 years ago and had been on hemodialysis twice a week. He got renal transplantation in June 1999. But anemia was not improved in first postoperative period. On admission hemoglobin was 43.0 g/L, hematocrit was 12.7%. The bone marrow biopsy revealed severe erythroid hypoplasia with giant pronormoblasts. The pronormoblasts showed prominent intranuclear inclusions, characteristic of parvovirus B19 infection. The parvovirus H19 PCR and anti-parvovirus B19 IgM were positive. The patient was treated with intravenous immunoglobulin and then reticulocyte count was in- creased 5 days later. Hemoglobin level restored to 104 g/L two months later.