Korean Journal of Nephrology 2001;20(4):584-592.

논평 : 증식성 및 비증식성 사구체신염에서 Cytokine 과 Chemokine 유전자의 발현 양상 (Editorial : Differential Expression of Various Cytokine and Chemokine Genes between Proliferative and Non - proliferative Glomerulonephritides)

이서진(Seo Jin Lee),김강석(Kang Suk Kim),정수환(Shou Huan Zheng),임춘수(Chun Soo Lim),윤형진(Hyung Jin Yoon),김연수(Yon Su Kim),안규리(Cu Rie Ahn),한진석(Jin Suk Han),노정우(Jung Woo Noh),채동완(Dong Wan Chae),이정상(Jung Sang Lee),김성권(Suhng Gwon Kim)

Abstract

Backgroud : Intraglomerular cellular proliferation is one of the major determinants for dividing various glomerulonephritis(GN) into two groups, such as proliferative versus nonproliferative. We hypothesized that this morphological difference could be based on the differential expression of various cytokines and chemokines. To elucidate this hypothesis we quantified the intrarenal gene expression of various cytokines and chemokines, and correlated it with clinical and histological parameters. Methods: Total RNA was extracted from 54 proliferative GN(PGN) core biopsy specimens and 42 nonproliferative GN(NPGN) specirnens. Using the internal competitors RT-PCR was instituted to quantify mRNAs. Results: The magnitude of the gene expressions of IL-2, IFN- r, and IFN- r /IL-10 ratio were signi- ficantly higher in PGN. RANTES and IL-8 had more abundant gene messages in PGN than in NPGN. It was shown that Thl cytokine was upregulated if GN was mediated by immune complexes regardless of cellular proliferation. Upregulation of the IFN- r / IL-10 ratio and TNF- αwas associated with renal dysfunction at the time of renal biopsy. Conclusion Thl, proinflammatory cytokines, and chemokines were more abundant in proliferative GN, and correlated with unfavorable clinical and histologic parameters. We propose that the clinical manifestations and diverse histologic features of human GN are associated with differential expressions of specific cytokines and chemokines. A new way of blocking the actions of these cytokines should be instituted for the treatment and prevention of the progression of GN.